[1]赵寅生a,易小敏b,屠昌明a,等.前列腺小体外泌蛋白检测在慢性前列腺炎诊断中的应用[J].现代检验医学杂志,2020,35(02):9-11.[doi:10.3969/j.issn.1671-7414.2020.02.003]
 ZHAO Yin-shenga,YI Xiao-minb,TU Chang-minga,et al.Application of Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis[J].Journal of Modern Laboratory Medicine,2020,35(02):9-11.[doi:10.3969/j.issn.1671-7414.2020.02.003]
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前列腺小体外泌蛋白检测在慢性前列腺炎诊断中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
9-11
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Application of Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis
文章编号:
1671-7414(2020)02-009-03
作者:
赵寅生a易小敏b屠昌明a黄其峰a吴黎黎a贾健安a
( 中国人民解放军联勤保障部队第901 医院a. 检验科,b. 泌尿外科,合肥 230031)
Author(s):
ZHAO Yin-shenga YI Xiao-minb TU Chang-minga HUANG Qi-fengaWU Li-liaJIA Jian-ana
(a. Departruent of Clinical Laboratory; b. Department of Urology, 901 Hospital of the Joint Logistics Support Force ofthe Chinese People’s Liberation Army, Hefei  230031, China)
关键词:
前列腺小体外泌蛋白慢性前列腺炎敏感度特异度ROC 曲线
分类号:
R697.33;R446.19
DOI:
10.3969/j.issn.1671-7414.2020.02.003
文献标志码:
A
摘要:
目的 探讨前列腺小体外泌蛋白(prostatic exosomal protein,PSEP)检测对慢性前列腺炎的诊断价值。方法收集102 例慢性前列腺炎患者和70 例健康体检者的尿液标本,应用前列腺小体外泌蛋白检测试剂盒,对患者尿液中PSEP 进行定量检测,评价其诊断前列腺炎的灵敏度、特异度和临界值等指标,比较PSEP 检测体系与临床诊断标准的差异。结果 慢性前列腺炎患者PSEP 检测结果为3.002(1.728~3.966)ng/ml,明显高于健康体检者的0.869(0.565~1.094)ng/ml,差异具有统计学意义(P<0.001)。根据受试者工作曲线计算PSEP 的最佳临界值为1.238 ng/ml,ROC 曲线下面积为0.922,对慢性前列腺炎的诊断敏感度为86.27%,特异度为90%。结论 检测患者尿液中的PSEP,取材方便,结果可靠,能提高患者依从性及就诊舒服度,可作为临床上慢性前列腺炎诊断现有方法的补充,为慢性前列腺炎患者临床诊断提供了新的检测依据,值得向临床推广应用。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:安徽省自然科学基金(编号:1708085QH204)。作者简介:赵寅生(1986-),男,硕士研究生,主管检验技师,主要从事临床检验工作,E-mail:396220428@qq.com。通讯作者:贾健安(1983-),男,博士研究生,主要从事临床检验分子诊断工作,E-mail:j.a_jia@foxmail.com。收稿日期:2019-11-18修回日期:2019-12-18
更新日期/Last Update: 2020-04-30