[1]洪 宏,袁建芬,喻海忠.乳腺癌患者血清长链非编码RNA ATB 表达水平检测及临床诊断价值[J].现代检验医学杂志,2020,35(02):22-23.[doi:10.3969 / j.issn.1671-7414.2020.02.007]
 HONG Hong,YUAN Jian-fen,YU Hai-zhong.Detection and Clinical Diagnosis Value of Serum Long Non-codingRNA ATB in Patients with Breast Cancer[J].Journal of Modern Laboratory Medicine,2020,35(02):22-23.[doi:10.3969 / j.issn.1671-7414.2020.02.007]
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乳腺癌患者血清长链非编码RNA ATB 表达水平检测及临床诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
22-23
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Detection and Clinical Diagnosis Value of Serum Long Non-codingRNA ATB in Patients with Breast Cancer
文章编号:
1671-7414(2020)02-022-03
作者:
洪 宏袁建芬喻海忠
(南通市中医院检验科, 江苏南通 226001)
Author(s):
HONG HongYUAN Jian-fenYU Hai-zhong
(Department of Clinical Laboratory, Nantong Hospital of Traditional Chinese Medicine, Jiangsu Nantong 226001, China)
关键词:
长链非编码RNAATB乳腺癌生物学标志物
分类号:
R737.9;R730.43
DOI:
10.3969 / j.issn.1671-7414.2020.02.007
文献标志码:
A
摘要:
目的 探讨长链非编码RNA(lncRNA)ATB 在乳腺癌患者血清中的表达水平及其对乳腺癌的诊断价值。方法 选取2017 年6 月~2019 年9 月期间收治的乳腺癌患者37 例,同期乳腺良性疾病患者30 例及健康体检者26 例作为研究对象,逆转录PCR(qRT-PCR) 检测各组血清中lncRNA-ATB 的表达水平,化学发光法检测各组血清CA153,受试者工作特征曲线分析单一及联合检测对乳腺癌的诊断价值。结果 乳腺癌患者血清中的lncRNA-ATB 相对表达量明显高于乳腺良性疾病患者(U=233,P < 0.01) 和健康体检者(U=131,P < 0.01),差异有统计学意义。单独检测lncRNA-ATB的ROC 曲线下的AUC 为0.824(95%CI:0.735 ~ 0.914),灵敏度为89.2%,特异度为67.9%。联合lncRNA-ATB 和CA153 检测的ROC 曲线下的AUC 为0.876(95%CI:0.800 ~ 0.953),灵敏度为83.8%,特异性为80.4%。结论 血清中高表达的lncRNA-ATB 可能为乳腺癌诊断的一个潜在的生物学标志物。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:南通市科技发展计划项目(MSZ18133)。作者简介:洪宏(1977-),女,硕士研究生,副主任技师,研究方向:分子生物学、乳腺肿瘤,E-mail:1823210139@qq.com。通讯作者:喻海忠(1967-),男,主任技师,硕士生导师,E-mail:yuhaizhong911@163.com。收稿日期:2019-11-29修回日期:2019-12-2
更新日期/Last Update: 2020-04-30