[1]刘小莉,张红梅,张 静,等.脊柱关节炎患者血清中25-(OH)D3,t-PINP,b-CTx 水平表达及临床相关性研究[J].现代检验医学杂志,2020,35(03):26-30.[doi:10.3969 / j.issn.1671-7414.2020.03.006]
 LIU Xiao-li,ZHANG Hong-mei,ZHANG Jing,et al.Expression of 25-(OH)D3,t-PINP,Β-CTx in Serum of Patients with Spinal Arthritis and Its Clinical Correlation[J].Journal of Modern Laboratory Medicine,2020,35(03):26-30.[doi:10.3969 / j.issn.1671-7414.2020.03.006]
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脊柱关节炎患者血清中25-(OH)D3,t-PINP,b-CTx 水平表达及临床相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
26-30
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Expression of 25-(OH)D3,t-PINP,Β-CTx in Serum of Patients with Spinal Arthritis and Its Clinical Correlation
文章编号:
1671-7414(2020)03-026-05
作者:
刘小莉张红梅张 静邹 明
(四川省骨科医院检验科,成都 610041)
Author(s):
LIU Xiao-li ZHANG Hong-mei ZHANG Jing ZOU Ming
( Department of Clinical Laboratory, Sichuan Provincial Orthopedic Hospital, Chengdu 610041, China)
关键词:
脊柱关节炎25 羟基维生素D3总I 型前胶原氨基端肽I 型胶原C 端肽
分类号:
R681.5;R392.11
DOI:
10.3969 / j.issn.1671-7414.2020.03.006
摘要:
目的 探讨脊柱关节炎(SpA)患者血清中25 羟基维生素D3[25-(OH)D3]、总I 型前胶原氨基端肽(t-PINP) 和I 型胶原C 端肽(β-CTx)的水平及与疾病活动度的相关性、中西医结合治疗前后水平变化。方法 选择2018 年 6 月~2019 年6 月在四川省骨科医院就诊且初次诊断为SpA 患者120 例作为病例组,其中包括强直性脊柱炎(AS) 患者60 例、放射学阴性脊柱关节炎(nr-ax SpA)患者30 例和外周型SpA 患者30 例,同时选择40 例健康体检者作 为对照组,检测血清中25-(OH)D3,t-PINP 和β-CTx 的水平。根据Bath 强直性脊柱炎活动性指数(BASDAI)评 分将SpA 患者分为疾病活动组(BASDAI>4.0)及非活动组(BASDAI ≤ 4.0),比较病例组与对照组、SpA 患者疾 病活动组与非活动组25-(OH)D3,t-PINP 和β-CTx 水平的差异,及随访40 例SpA 患者治疗前后水平的变化。结果  SpA 患者25-(OH)D3 水平低于对照组,t-PINP 和β-CTx 水平高于对照组,差异均有统计学意义(t=7.520,4.118,4.128, 均P<0.05), 而AS,nr-ax SpA, 外周型SpA 患者之间三个指标的差异无统计学意义(F=0.070~0.236, 均 P>0.05)。在AS,nr-ax SpA 和外周型SpA 中,疾病活动组t-PINP,β-CTx 高于非活动组,25-(OH)D3 水平只有 AS 组降低(P<0.05),且t-PINP,β-CTx 水平与BASDAI 评分呈正相关。随访40 例SpA 患者接受中西医结合 治疗3 个月后25-(OH)D3 水平升高,t-PINP,β-CTx 水平降低(P<0.05)。结论 SpA 患者外周血中存在25-(OH) D3,t-PINP 和β-CTx 水平的异常表达,在疾病活动期表现得更加明显。检测25-(OH)D3,t-PINP 和β-CTx 水平对 SpA 患者疾病活动性及病情监测具有一定的价值。
Abstract:
Objective To study the expression of 25 hydroxyvitamin D3 [25-(OH)D3], total procollagen type 1 aminoterminal peptide (t-PINP), C-telopeptides of type 1 collagen (β-CTx) in serum of patients with spinal arthritis (SpA), their correlation with disease activity, and the changes before and after treatment. Methods From June 2018 to June 2019, 120 patients with SpA were selected as a case group, including 60 patients with ankylosing spondylitis (AS), 30 patients with radio-negative spinal arthritis (nr-ax SpA) and 30 patients with peripheral SpA. At the same time, 40 healthy subjects were selected as the control group. The levels of 25-(OH)D3, t-PINP and β-CTx in serum of the control group and the case group were detected. According to the BASDAI score, SpA patients were divided into disease activity group and inactive group, and the difference of those tree markers between the control group and the case group, the SpA patient disease activity group and the inactive group, and the 40 patients with SpA before and after treatment were observed. Results The level of 25-(OH)D3 in SpA patients was significantly lower than that in the control group, while the levels of t-PINP and β-CTx were significantly increased (t=7.520,4.118,4.128, all P<0.05). However, there was no significant difference between AS, nr-ax SpA and peripheral SpA patients (F=0.070~0.236, all P>0.05). In SpA patients, the level of 25-(OH)D3 in the disease activity group was significantly lower than that in the non-disease activity group, and the levels of t-PINP and β-CTx were significantly increased (P<0.05).The levels of t-PINP and β-CTx were positively correlated with BASDAI score. The level of 25-(OH)D3 was significantly increased in SpA patients who were treated 3 months, and the levels of t-PINP and β-CTx were significantly decreased (P<0.05). Conclusion Abnormal expression of 25-(OH)D3,t-PINP and β-CTx levels in SpA patients, which is more obvious in the active phase of the disease. Detection of 25-(OH)D3,t-PINP and β-CTx levels plays an important role in the monitoring of disease activity and condition in patients with spinal arthritis.

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备注/Memo

备注/Memo:
收稿日期:2020-03-12 修回日期:2020-03-24作者简介:刘小莉(1988-),女,硕士研究生,检验师,主要从事自身免疫性疾病实验室诊断,E-mail:236550934@qq.com。
更新日期/Last Update: 2020-07-20