[1]杨丽华,樊爱琳,刘家云,等.尿液吞噬细胞检测在泌尿系统疾病诊断中的应用价值[J].现代检验医学杂志,2020,35(05):57-61.[doi:10.3969/j.issn.1671-7414.2020.05.015]
　YANG Li-hua,FAN Ai-lin,LIU Jia-yun,et al.Application Value of Urine Phagocytic Cell Detection in the Diagnosis of Urinary System Diseases[J].Journal of Modern Laboratory Medicine,2020,35(05):57-61.[doi:10.3969/j.issn.1671-7414.2020.05.015]
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尿液吞噬细胞检测在泌尿系统疾病诊断中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
57-61
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
Application Value of Urine Phagocytic Cell Detection in the Diagnosis of Urinary System Diseases
文章编号:
1671-7414（2020）05-061-05
作者:
杨丽华; 樊爱琳; 刘家云; 丁振若
空军军医大学西京医院检验科，西安710032
Author(s):
YANG Li-hua;  FAN Ai-lin;  LIU Jia-yun;  DING Zhen-ruo
Department of Laboratory Medicine , Xijing Hospital of Air Force Medical University, Xi’an 710032,China
关键词:
吞噬细胞; 泌尿系统疾病; 大吞噬细胞; 泌尿系感染; 小吞噬细胞; 肾小球肾炎
分类号:
R69；R446.12
DOI:
10.3969/j.issn.1671-7414.2020.05.015
文献标志码:
A
摘要:
目的　分析817 例尿液标本吞噬细胞的检测结果，评价吞噬细胞在泌尿系统疾病诊断中的应用价值。方法　选 取西京医院检验科尿液红细胞形态门诊2019 年1 ～ 12 月就诊患者817 例，其中原发性肾小球肾炎患者623 例，继发性 肾病患者61 例，急性肾盂肾炎患者12 例，急性膀胱炎患者20 例，慢性上尿路感染患者41 例，正常尿液成分组19 例， 观察尿液有形成分中吞噬细胞形态并统计其在不同疾病组的检出率，进行统计分析。结果　正常尿液成分组吞噬细胞检 出率15.79%。与正常尿液成分组相比较，急性肾盂肾炎组检出率100%，急性膀胱炎组检出率100%，原发性肾小球肾 炎组吞噬细胞检出率86.35%，继发性肾病组吞噬细胞检出率67.21%，慢性上尿路感染组吞噬细胞检出率60.97%，差异 均有统计学意义（χ2=10.651~64.036，均P<0.01）。其中在急性泌尿系统感染检出率最高，其次为原发性肾小球肾炎。 在不同疾病中吞噬细胞形态有所差异，在泌尿系感染时多见大吞噬细胞，在原发性肾小球肾炎时多见小吞噬细胞。结论　 吞噬细胞不仅在尿路感染中有很高的检出率，在肾小球相关疾病中也有较高的检出率，且形态有所不同。
Abstract:
Objective　 To analyze the detection results of phagocytes in 817 urine samples and evaluate the application value of phagocytes in the diagnosis of urinary system diseases. Methods　A total of 817 patients from January to December 2019 in the red blood cell morphology clinic of Department of Laboratory Medicine of Xijing Hospital were selected.Among them, 623 cases were primary glomerulonephritis, 61 cases were secondary kidney disease, 12 cases were acute pyelonephritis, 20 cases were acute cystitis, 41 cases were chronic upper urinary tract infection, and 19 cases were normal urine composition group,and the morphology of phagocytes in urine was observed and the detection rate of phagocytes in different disease groups was statistically analyzed. Results　The detection rate of phagocytes in normal urine was 15.79%. Compared with the normal urine grouping, the detection rate of phagocytic cells in the acute pyelonephritis group was 100%, that in the acute cystitis group was 100%, that in the primary glomerulonephritis group was 86.35%, that in the secondary nephropathy group was 67.21%, and that in the chronic upper urinary tract infection group was 60.97%. The differences were statistically significant（χ2=10.651~64.036, all P<0.01）. The detection rate of acute urinary tract infection was the highest, followed by primary glomerular disease. The morphology of phagocytes was different in different diseases, large phagocytes were more common in urinary tract infection, and small phagocytes were more common in primary glomerulonephritis. Conclusion　Phagocytic cells had a high detection rate not only in urinary tract infection, but also in glomerular-related diseases.

参考文献/References:

[1]　 SCOTT N A，MANN E R. Regulation of mononuclear phagocyte function by the microbiota at mucosal sites[J]. Immunology, 2020, 159(1): 26-38.
[2]　 MAXFIELD F R, BARBOSA-LORENZI V C, SINGH R K. Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis[J]. Traffic, 2020, 21(1): 6-12.
[3]　 胡兰娟，马登扬，刘胜勇，等．尿液中相关指标对 尿路感染初筛评价[J]．中国预防医学杂志,2019,20 （5）:430-433． 　　 HU Lanjuan,MA Dengyang,LIU Shengyong，et al. The valuation of primary screen of urinary tract infection by the index of urine NIT, LEU, WBC and bacteriuria [J]. China Preventive Medicine, 2019,20(5):430-433.
[4]　 丁振若，于文彬，苏明权，等. 尿液沉渣临床检验 图谱[M]. 郑州：河南科学技术出版社,2017. 　　 DING Zhenruo,YU Wenbin,SU Mingquan， et al. Clinical examination atlas of urinary sediment[M].Zhengzhou: Henan Science and Technology Press, 2017.
[5]　 闫立志，吴茅，王庚，等. 尿液有形成分图谱新 解及病例分析[M]. 长沙：湖南科学技术出版社， 2019. 　　 YAN Lizhi,WU Mao,WANG Geng ，et al. New understanding of visible component atlas of urine and case analysis[M].Changsh:Hunan Science and Technology Press, 2019.
[6]　 卢佩，刘海波，丁振若，等．尿液中不同形态的吞 噬样细胞在泌尿系统疾病诊断中的临床价值[J]．检 验医学与临床,2019,16（17）:2506-2508． 　　 LU Pei, LIU Haibo, DING Zhenruo，et al. Clinical value of different forms of phagocytic cells in urine in the diagnosis of urinary system diseases[J]. Laboratory Medicine and Clinic , 2019,16(17):2506-2508.
[7]　 韦晓明, 丁振若, 郑善銮，等. 尿液混合细胞群检测 在肾盂肾炎诊断中的应用[J]. 临床检验杂志,2010,28 （1）:33-35. 　　 WEI Xiaoming,DING Zhenruo,ZHENG Shanluan ，et al. The application of urine mixed cell group detection in the diagnosis of pyelonephritis[J]. Chinese Journal of Clinical Laboratory Science , 2010,28(1):33-35.
[8]　 钟璇. 尿常规检测对尿路感染的临床诊断意义分析 [J]. 临床检验杂志( 电子版)， 2020,9(1):74. 　　 ZHONG Xuan. The significance of routine urinary examination in the diagnosis of urinary tract infection[J]. Clinical Laboratory Journal (Electronic Edition), 2020,9(1):74.
[9]　 俞坤花. 全自动尿液有形成分分析仪细菌检测对尿 路感染诊断的效果研究[J]. 临床检验杂志（电子版）， 2020,9(1):191. 　　 YU Kunhua. Study on the diagnosis of urinary tract infection by bacterial detection with automatic urine visible component analyzer[J]. Clinical Laboratory Journal (Electronic Edition), 2020,9(1):191.
[10] 孙召洋，刘文健，张景皓，等. 泌尿系统感染检测 方法研究进展[J]. 检验医学,2019,34 (12):1133-1138. 　　 SUN Shaoyang, LIU Wenjian, ZHANG Jinghao, et al. Advances in the detection of urinary tract infections[J]. Laboratory Medicine, 2019,34 (12):1133-1138.
[11] 汪琳琳．尿中吞噬细胞噬菌现象在尿路感染患 者中的诊断意义[J]. 泰山医学院学报,2014,35 （12）:1309. 　　 WANG Linlin. The diagnostic significance of phagocytosis in urine in patients with urinary tract infection[J]. Journal of Taishan Medical College, 2014,35（12）:1309．
[12] 谢模政，龙雪梅，张威．巨噬细胞在急性肾脏损伤 中作用的研究进展[J]．现代泌尿外科杂志，2019， 24（2）:158-162． 　　 XIE Mozheng,LONG Xuemei,ZHANG Wei. Research progress on the role of macrophages in acute kidney injury[J]. Journal of Modern Urology, 2019,24(2):158- 162.
[13] 王海燕. 肾脏病学[M].3 版. 北京：人民卫生出版 社,2018. 　　 WANG Haiyan . Nephrology [M]. 3th ed. Beijing： People's Medical Publishing House,2018.

备注/Memo

备注/Memo:
作者简介：杨丽华（1981-），女，医学硕士，主治医师，主要从事尿液、浆膜腔积液形态学等方向研究，E-mail：39781403@qq.com。
通讯作者：樊爱琳（1970-），女，医学博士，副主任医师，主要从事血液、体液形态学研究，E-mail：fanailin@fmmu.edu.cn。
更新日期/Last Update: 2020-10-30