[1]徐晓锋a,王 纯b,卢国丰a,等.宫颈癌患者 Kruppel 样因子 6,p21 蛋白表达水平与病理特征及化疗敏感性的相关性分析[J].现代检验医学杂志,2020,35(06):12-15.[doi:doi:10.3969/j.issn.1671-7414.2020.06.004]
 XU Xiao-feng a,WANG Chun b,LU Guo-feng a,et al.Correlation Analysis of KLF6 and p21 Protein Expression Levels andPathological Features and Chemotherapy Sensitivity in Patientswith Cervical Cancer[J].Journal of Modern Laboratory Medicine,2020,35(06):12-15.[doi:doi:10.3969/j.issn.1671-7414.2020.06.004]
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宫颈癌患者 Kruppel 样因子 6,p21 蛋白表达水平与病理特征及化疗敏感性的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
12-15
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Correlation Analysis of KLF6 and p21 Protein Expression Levels andPathological Features and Chemotherapy Sensitivity in Patientswith Cervical Cancer
文章编号:
1671-7414(2020)06-012-04
作者:
徐晓锋a王 纯b卢国丰a 孟亚萍a 周勤芬a 胡明珠a 石 琴a
(上海健康医学院附属嘉定区中心医院 a. 妇产科;b. 病理科,上海 201800)
Author(s):
XU Xiao-feng a WANG Chun b LU Guo-feng a MENG Ya-ping a ZHOU Qin-fen a HU Ming-zhu a SHI Qin a
(a. Department of Obstetrics and Gynecology ; b. Department of Pathology, Jiading Central Hospital Affiliated toShanghai Health Medical College, Shanghai 201800,China)
关键词:
宫颈癌Kruppel 样因子 6p21 蛋白病理特征化疗敏感性相关性
分类号:
R737.33;R730.43
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.004
文献标志码:
A
摘要:
目的 探讨宫颈癌患者 Kruppel 样因子 6(KLF6),p21 蛋白表达水平与病理特征及化疗敏感性的相关性。方法 回顾性分析 2016 年 1 月 ~2018 年 12 月接受化疗的 40 例宫颈癌患者,化疗结束后根据化疗效果将患者分为化疗敏感组(CR+PR)、化疗抵抗组(SD+PD)。采用免疫组化检测宫颈癌组织 KLF6,p21 蛋白的表达,分析其与临床病理特征、化疗敏感性及总生存期(OS)的关系。结果 宫颈癌中 KLF6,p21 蛋白阳性率与病理分期、肿瘤直径、分化类型及化疗敏感性相关(χ 2 =2.14~5.74,均 P<0.05)。KLF6+/p21- 者 ORR 为 85.71%,显著高于非 KLF6+/p21- 者 42.11%(χ 2 =8.33,P<0.05)。宫颈癌患者的中位 OS 为 11.20 个月(95%CI: 9.73~12.71),其中 KLF6 阳性者中位 OS 为 11.90个月(95%CI: 10.81~12.99),显著高于阴性表达者 9.20 个月(95%CI: 9.05~9.35);p21 蛋白阳性者中位 OS 为 9.14 个月(95%CI: 8.26~10.22),显著低于 p21 阴性表达者 11.62 个月(95%CI: 9.63~13.58)(χ 2 =11.50,6.23,均 P<0.05)。结论 宫颈癌患者 KLF6,p21 表达水平与其临床病理特征相关。KLF6 高表达、p21 低表达者化疗敏感性高,且预后更好,可作为预后、个体化治疗方案选择的评价指标。

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更新日期/Last Update: 2020-12-20