[1]陈元菁,艾红军,王湘云,等.COPD 患者线粒体功能及代谢水平变化检测与骨骼肌功能障碍的相关性研究[J].现代检验医学杂志,2020,35(06):25-27.[doi:doi:10.3969/j.issn.1671-7414.2020.06.007]
 CHEN Yuan-jing,AI Hong-jun,WANG Xiang-yun,et al.Study on the Correlation between Changes Detection in Mitochondrial Function,Metabolic Level and Skeletal Muscle Dysfunction Inpatients with COPD[J].Journal of Modern Laboratory Medicine,2020,35(06):25-27.[doi:doi:10.3969/j.issn.1671-7414.2020.06.007]
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COPD 患者线粒体功能及代谢水平变化检测与骨骼肌功能障碍的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
25-27
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Study on the Correlation between Changes Detection in Mitochondrial Function,Metabolic Level and Skeletal Muscle Dysfunction Inpatients with COPD
文章编号:
1671-7414(2020)06-025-04
作者:
陈元菁艾红军王湘云吴 琼常 雁刘锦铭
(上海市杨浦区控江医院呼吸科,上海 200090)
Author(s):
CHEN Yuan-jing AI Hong-jun WANG Xiang-yun WU Qiong CHANG Yan LIU Jin-ming
(Department of Respiratory Medicine, Kongjiang Hospital of Yangpu District in Shanghai, Shanghai 200090,China)
关键词:
慢性阻塞性肺疾病线粒体代谢骨骼肌功能障碍
分类号:
R563;R446.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.007
文献标志码:
A
摘要:
目的 探讨慢性阻塞性肺疾病(COPD)线粒体功能、代谢水平变化与骨骼肌功能障碍(SMD)的相关性。方法 将 2018 年 12 月 ~2019 年 12 月上海市杨浦区控江医院呼吸内科门诊就诊的 60 例 COPD 患者,根据是否并发 SMD分为 COPD-SMD 组(n=21)和 COPD 组(n=39),另选择同期健康体检者 30 例作为对照组。比较各组外周血单核细胞(PBMCs)mtDNA 拷贝数、线粒体膜电位和细胞内活性氧(ROS)、血清胰岛素样生长因子 -1(IGF-1)、瘦素 (LP)和空腹胰岛素 (FINS) 等指标,分析线粒体功能、代谢水平与股神经动作电位时间和股神经传导速度的相关性。结果与对照组比较,COPD 组和 COPD-SMD 组 PBMCs 中 mtDNA 拷贝数和膜电位显著下降,ROS 则显著升高(t=4.03~9.97,2.92~6.75 和 2.73~3.92, 均 P<0.05),上述指标在 COPD-SMD 组与 COPD 组比较,差异有统计学意义(t=10.26,5.28和 9.24, 均 P<0.05)。COPD-SMD 组、COPD 组 LP 和 FINS 显著高于对照组,IGF-1 较对照组显著降低(t=5.57~8.50,5.27~6.64和3.27~11.57, 均P<0.05)。COPD-SMD组LP和FINS显著高于COPD组,IGF-1较COPD组显著降低(t=10.25,14.26 和 8.01, 均 P<0.05)。股神经传导时间与 mtDNA,膜电位和 LP 均呈显著负相关(r=-0.475,-0.440 和 -0.416,均 P<0.05),与 ROS 和 IGF-1 呈显著正相关性(r=0.421 和 0.471,P<0.05);股神经动作电位幅度与 mtDNA,膜电位、LP 和 FINS 均呈显著正相关(r=0.451,0.464,0.435 和 0.375,均 P<0.05),与 ROS 和 IGF-1 呈显著负相关(r=-0.447和 -0.391,均 P<0.05)。结论 COPD 患者存在线粒体功能减退,代谢水平异常,且与 SMD 的发生密切相关。

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更新日期/Last Update: 2020-12-20