[1]陶昭君a,成 军b,戴玉柱b.甲状腺疾病患者血清 Tg-CIC 中 Tg-Ab 水平检测及相关临床研究[J].现代检验医学杂志,2020,35(06):28-32.[doi:doi:10.3969/j.issn.1671-7414.2020.06.008]
 TAO Zhao-jun a,CHENG Jun b,DAI Yu-zhu b.Detection and Related Clinical Research of Tg-Ab in Serum ThyroglobulinImmune Complex (Tg-CIC) in Patients with Thyroid Diseases[J].Journal of Modern Laboratory Medicine,2020,35(06):28-32.[doi:doi:10.3969/j.issn.1671-7414.2020.06.008]
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甲状腺疾病患者血清 Tg-CIC 中 Tg-Ab 水平检测及相关临床研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
28-32
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Detection and Related Clinical Research of Tg-Ab in Serum ThyroglobulinImmune Complex (Tg-CIC) in Patients with Thyroid Diseases
文章编号:
1671-7414(2020)06-028-05
作者:
陶昭君a 成 军b 戴玉柱b
( 中国人民解放军联勤保障部队第九〇三医院 a. 医学工程科;b. 检验科,杭州 310013)
Author(s):
TAO Zhao-jun a CHENG Jun b DAI Yu-zhu b
(a.Department of Medical Engineering;b.Department of Clinical Laboratory, 903rd Hospital of PLA ,Hangzhou 310013,China)
关键词:
甲状腺疾病甲状腺球蛋白免疫复合物抗甲状腺球蛋白抗体
分类号:
R581;R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.008
文献标志码:
A
摘要:
目的 对血清甲状腺球蛋白免疫复合物 (thyroglobulin circulating immune complex, Tg-CIC) 中抗甲状腺球蛋白抗体 (anti-thyroglobulin antibody, Tg-Ab) 含量检测,探讨 Tg-CIC 在甲状腺疾病中的临床以及流行病学意义。方法 收集甲状腺疾病患者血清标本 187 例,每例血清标本分为两组 ( 实验组和空白对照组 ),采用免疫复合物解离专利技术对甲状腺疾病患者血清标本 Tg-CIC 进行分离、解离,通过检测 Tg-CIC 解离后的 Tg-Ab 含量来间接反映甲状腺疾病患者血清中Tg-CIC 水平,按照不同的甲状腺疾病进行分组并对实验结果分析讨论。结果 不同甲状腺患者血清中 Tg-CIC 总阳性率达 92.51%,不同甲状腺疾病血清中 Tg-CIC 的阳性率差异无统计学意义 (χ?=2.917, P>0.05)。不同甲状腺疾病患者间血清游离 Tg-Ab 含量差异无统计学意义 (H=3.882, P>0.05),不同甲状腺疾病患者间血清 CIC 中 Tg-Ab 含量差异无统计学意义(H=5.5842, P>0.05)。不同甲状腺疾病患者中,甲状腺功能亢进、甲状腺炎以及甲状腺结节患者血清游离 Tg-Ab 的含量与血清 CIC 中的 Tg-Ab 含量呈正相关 (P<0.05),甲状腺功能减退、甲状腺肿瘤患者血清游离 Tg-Ab 的含量与血清 CIC 中的Tg-Ab 含量不相关 (P>0.05)。结论 在甲状腺疾病患者血清中,大部分可检出 Tg-CIC,与疾病类型无关。而甲状腺疾病患者中,甲状腺功能亢进、甲状腺炎以及甲状腺结节患者血清游离 Tg-Ab 含量与血清 CIC 中 Tg-Ab 含量存在相关性,为我们进一步了解 Tg-CIC 与甲状腺疾病的发生、发展的相关性研究奠定了基础,提供了新的研究视角。

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更新日期/Last Update: 2020-12-20