[1]邹慧莉,杨伟毅,刘　燕.动脉粥样硬化性缺血性脑血管病患者外周血 TNF-α，IL-6，IL-8 和 WBC 水平与慢性失眠症 PSQI 的相关性研究[J].现代检验医学杂志,2020,35(06):68-71.[doi:doi:10.3969/j.issn.1671-7414.2020.06.017]
　ZOU Hui-li,YANG Wei-yi,LIU Yan.Correlation between Levels of TNF-α, IL-6, IL-8 and WBC in PeripheralBlood of Patients with Atherosclerotic Ischemic Cerebrovascular Diseaseand PSQI in Chronic Insomnia[J].Journal of Modern Laboratory Medicine,2020,35(06):68-71.[doi:doi:10.3969/j.issn.1671-7414.2020.06.017]
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动脉粥样硬化性缺血性脑血管病患者外周血 TNF-α，IL-6，IL-8 和 WBC 水平与慢性失眠症 PSQI 的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
68-71
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Correlation between Levels of TNF-α, IL-6, IL-8 and WBC in PeripheralBlood of Patients with Atherosclerotic Ischemic Cerebrovascular Diseaseand PSQI in Chronic Insomnia
文章编号:
:1671-7414（2020）06-068-05
作者:
邹慧莉1 ; 杨伟毅1 ; 刘　燕2
（1. 西安大兴医院，西安 710016；2. 渭南市中心医院神经内科，陕西渭南 714000）
Author(s):
ZOU Hui-li 1 ; YANG Wei-yi 1 ; LIU Yan 2
（1.Xi’an Daxing Hospital，Xi’an 710016，China; 2.Department of Neurology, Weinan Central Hospital,Shaanxi Weinan 714000,China）
关键词:
动脉粥样硬化性缺血性脑血管病; 慢性失眠症; 匹兹堡睡眠质量指数; 炎症反应
分类号:
R743.1；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.017
文献标志码:
A
摘要:
目的　分析动脉粥样硬化性缺血性脑血管病患者外周血肿瘤坏死因子 α（TNF-α）、白介素 -6（IL-6）、白介素 -8（IL-8）和白细胞（WBC）水平与慢性失眠症匹兹堡睡眠质量批数（PSQI）的相关性。方法　将 103 例动脉粥样硬化性缺血性脑血管病患者 (2019 年 1~12 月收治 ) 分为不伴失眠症组 (PSQI 评分≤ 10 分，共 66 例 ) 和伴失眠症组(PSQI 评分 >10 分，共 37 例 )。不伴失眠症组和伴失眠症组均未经治疗行外周血 TNF-α，IL-6，IL-8 和 WBC 检测，分析两组的外周血 TNF-α，IL-6，IL-8，WBC 和 PSQI 评分差异，采用 Pearson 秩相关法分析外周血 TNF-α，IL-6，IL-8和 WBC 与 PSQI 评分之间的相关性。结果　伴失眠症组的 TNF-α(26.49±4.82 nmol/L)，IL-6(16.92±3.44 pg/ml)，IL-8(21.45±3.87 pg/ml) 和 PSQI(16.74±2.25 分 ) 高于不伴失眠症组 (22.19±4.64 nmol/L，13.62±3.03 pg/ml，17.91±3.14pg/ml 和 6.91±1.93 分 )，伴失眠症组的 WBC[(6.41±1.28)×10 9 /L] 低于不伴失眠症组 [(8.76±1.46)×10 9 /L]，经 t 检验分析差异均具有统计学意义 (t=4.450~9.098，均 P<0.05)。外周血 TNF-α，IL-6 和 IL-8 水平均与 PSQI 呈正相关，经Pearson 秩相关法分析 (r =0.874 3~ 0.933 9，P <0.05)；外周血 WBC 水平与 PSQI 呈负相关，经 Pearson 秩相关法分析 (r= - 0.843 0，P=0.000)。结论　动脉粥样硬化性缺血性脑血管病并发慢性失眠症患者具有明显的炎症反应和白细胞浸润，且炎症反应、白细胞浸润的程度越高，并发慢性失眠症的程度越严重。

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更新日期/Last Update: 2020-12-20