[1]毕开湘a,陶红莉,杨丽丽 b.孤独症谱系障碍儿童血清叶酸与脑源性神经营养因子水平检测的临床意义[J].现代检验医学杂志,2020,35(06):171-175.[doi:doi:10.3969/j.issn.1671-7414.2020.06.042]
 BI Kai-xiang a,TAO Hong-li,YANG Li-li b.Clinical Significance of the Detection of Folic Acid and Brain-derivedNeurotrophic Factor in Children with Autism Spectrum Disorder[J].Journal of Modern Laboratory Medicine,2020,35(06):171-175.[doi:doi:10.3969/j.issn.1671-7414.2020.06.042]
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孤独症谱系障碍儿童血清叶酸与脑源性神经营养因子水平检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
171-175
栏目:
检验与临床
出版日期:
2020-12-30

文章信息/Info

Title:
Clinical Significance of the Detection of Folic Acid and Brain-derivedNeurotrophic Factor in Children with Autism Spectrum Disorder
文章编号:
1671-7414(2020)06-171-05
作者:
毕开湘1a 陶红莉 2 杨丽丽 1b
(1. 宝鸡市康复医院 a. 精神科 ;b. 社区中心,陕西宝鸡 721000;2. 咸阳市中心医院精神心理科,陕西咸阳 712000)
Author(s):
BI Kai-xiang 1a TAO Hong-li 2 YANG Li-li 1b
(1a.Department of Psychiatry;1b. Community Center, Baoji Rehabilitation Hospital,Shaanxi Baoji 721000,China;2.Department of Psychiatry, Xianyang Central Hospital,Shaanxi Xianyang 712000,China)
关键词:
叶酸脑源性神经营养因子孤独症谱系障碍早期诊断
分类号:
R749.1;R446.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.042
文献标志码:
A
摘要:
目的 研究叶酸和脑源性神经营养因子(BDNF)检测在孤独症谱系障碍(ASD)患儿中的临床意义。方法纳入 2017 年 3 月 ~2020 年 3 月 56 例 ASD 患儿作为观察组,按 1:1 比例,另纳入同期 56 例体检健康儿童作为对照组。分别采用化学发光微粒子免疫分析技术(CMIA)和酶联免疫吸附法(ELISA)检测血清叶酸和 BDNF 水平,比较两组儿童血清叶酸和 BDNF 水平。采用儿童孤独症评定量表(CARS)记录 ASD 患儿病情状态,并分析血清叶酸和 BDNF与 CARS 评分的关系。分析血清叶酸水平对判断 ASD 及病情程度的价值,比较不同患儿血清 BDNF 水平,分析 BDNF水平影响因素。结果 观察组患儿血清叶酸水平显著低于对照组(15.39±7.41 nmol/L vs 19.61±6.09 nmol/L),BDNF显著高于对照组(25.88±11.05 pg/ml vs 20.48±10.30 pg/ml),差异均有统计学意义(t=2.941,2.670,均 P<0.05)。不同病情程度 ASD 患儿血清叶酸水平比较,差异均有统计学意义(F=14.797,P<0.05)。轻中度 ASD 患儿 BDNF 显著高于重度患儿及健康对照组儿童,差异均有统计学意义(t=2.833,3.130,均 P<0.05)。Pearson 线性相关分析显示CARS 评分与血清叶酸水平呈显著负相关性(r = -0.317,P=0.000)。CARS 评分与血清 BDNF 水平无显著相关性(r =0.074,P=0.132)。受试者工作曲线(ROC)分析显示血清叶酸对判断ASD和重度ASD均具有一定应用价值(AUC=0.779,0.768;P<0.05)。多元线性回归分析结果显示年龄(b=1.214,P<0.05)、家族史(b=2.927,P<0.05)及病情程度(b=3.210,P<0.05)是影响血清 BDNF 水平的独立因素。结论 叶酸和 BDNF 与 ASD 关系密切,叶酸检测可作为 ASD 早期诊断和病情程度判断的指标,BDNF 则是 ASD 的保护因素,但其水平受患儿年龄、家族史及病情程度等影响。

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更新日期/Last Update: 2020-12-20