[1]何 进,张 艳,申娴娟,等.多发性骨髓瘤患者血清可溶性PD-L1水平在辅助诊断及临床分型的价值研究[J].现代检验医学杂志,2021,36(02):15-18.[doi:doi:10.3969/j.issn.1671-7414.2021.02.004]
 HE Jin,ZHANG Yan,SHEN Xian-juan,et al.Value of Blood Soluble PD-L1 in the Auxiliary Diagnosis and Clinical Subtype of Multiple Myeloma[J].Journal of Modern Laboratory Medicine,2021,36(02):15-18.[doi:doi:10.3969/j.issn.1671-7414.2021.02.004]
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多发性骨髓瘤患者血清可溶性PD-L1水平在辅助诊断及临床分型的价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
15-18
栏目:
论 著
出版日期:
2021-04-30

文章信息/Info

Title:
Value of Blood Soluble PD-L1 in the Auxiliary Diagnosis and Clinical Subtype of Multiple Myeloma
文章编号:
1671-7414(2021)02-015-05
作者:
何 进张 艳申娴娟
(1. 杭州余杭嘉木护理院,杭州 310000;2. 南通大学附属医院a.医学检验中心;b.临床医学研究中心,江苏南通 226001)
Author(s):
HE Jin ZHANG Yan SHEN Xian-juan et al
(1.Hangzhou Yuhang Jiamu Nursing Home, Hangzhou 310000,China;2a.Center of Laboratory Medicine ;b.Research Center of Clinical Medicine, Affiliated Hospital of Nantong University,Jiangsu Nantong 226001,China)
关键词:
多发性骨髓瘤可溶性程序性死亡受体-1受试者工作特征曲线
分类号:
R733.3;R730.43
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.004
文献标志码:
A
摘要:
目的 探讨多发性骨髓瘤(multiple myeloma,MM)患者血液可溶性程序性死亡受体-1(soluble programmed death-ligand 1,sPD-L1)表达及临床意义。方法 选取MM患者65例(MM组),健康体检者65例(对照组);酶联免疫吸附测定法(ELISA)检测sPD-L1表达量;采用受试者工作特征(receiver operator characteristic curve,ROC)曲线评估各指标单独及联合检测对MM的诊断效能。结果 MM组和对照组sPD-L1表达量分别为1.330(0.482,3.000)ng/ml和0.310(0.280,0.360)ng/ml,MM患者显著高于健康对照者,差异有统计学意义(P<0.05);ISS-II期患者sPD-L1表达水平高于ISS-I期(P<0.05),ISS-III期患者sPD-L1水平高于ISS-II期患者(P<0.05);sPD-L1表达水平与β2微球蛋白(β2-microglobulin,β2M)相关(P=0.033);sPD-L1曲线下面积(AUC)为0.789,高于β2M,λ轻链和κ轻链。sPD-L1诊断MM的灵敏度最高,sPD-L1,λ轻链和β2M单独或者联合应用得到较理想的诊断效能。结论 MM患者sPD-L1表达水平增高,检测sPD-L1水平变化可用于MM的辅助诊断及临床分型。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(NO. 81271920)。
作者简介:何进(1984-),男,主管技师,主要从事临床生化与分子生物检验,E-mail:153445920@qq.com。
通讯作者:鞠少卿,男,主任技师,博士生导师,主要从事分子标志物的基础与临床研究,E-mail: Jsq814@hotmail.com。
更新日期/Last Update: 2021-04-10