[1]赵智凝,武　易,刘　芳,等.慢性肾病患者血清Klotho，HE4，UMOD表达水平与疾病预后的相关性研究[J].现代检验医学杂志,2021,36(02):28-31.[doi:doi:10.3969/j.issn.1671-7414.2021.02.007]
　ZHAO Zhi-ning,WU Yi,LIU Fang,et al.Study on the Relationship between the Expression Level of Klotho, HE4 and Uromodulin and the Development of Chronic Kidney Disease[J].Journal of Modern Laboratory Medicine,2021,36(02):28-31.[doi:doi:10.3969/j.issn.1671-7414.2021.02.007]
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慢性肾病患者血清Klotho，HE4，UMOD表达水平与疾病预后的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
28-31
栏目:
论　著
出版日期:
2021-04-30

文章信息/Info

Title:
Study on the Relationship between the Expression Level of Klotho, HE4 and Uromodulin and the Development of Chronic Kidney Disease
文章编号:
1671-7414（2021）02-028-05
作者:
赵智凝; 武　易; 刘　芳; 等
(第四军医大学西京医院检验病理科，西安 710054)
Author(s):
ZHAO Zhi-ning;  WU Yi;  LIU Fang;  et al
(Department of Laboratory Medicine and Pathology, Xijing Hospital, Fourth Military Medical University, Xi’an 710054, China)
关键词:
慢性肾病; Klotho; 人附睾蛋白4; 尿调节素; 预后相关性
分类号:
R692；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.007
文献标志码:
A
摘要:
目的　研究慢性肾病(chronic kidney disease, CKD)患者血清Klotho，人附睾蛋白4(HE4)和尿调节素 (UMOD)表达水平在评估疾病预后中的参考价值。方法　对120例CKD患者及100例健康体检对照者血清同时应用ELISA检测Klotho和HE4，电化学发光法检测UMOD表达水平，分析各因子与肾小球滤过率(GFR)之间的关系。患者随访12个月后，根据GFR下降幅度分为恶化组和稳定组，比较两组之间血清因子变化差异，采用Kaplan-Meier生存曲线分析血清因子与预后的关系。结果　CKD患者血清Klotho，UMOD，GFR和HE4表达水平与健康对照组相比，差异均有统计学意义（t=22.492，58.235，23.668和33.341，均P<0.05）。Klotho，UMOD与GFR呈现正相关性（r=0.682，0.582，P<0.001），HE4与GFR呈负相关性（r=-0.627，P<0.001）。随访结束时血清Klotho，UMOD水平明显低于随访前，HE4水平明显高于随访前，恶性组患者的变化幅度与稳定组相比差异有统计学意义（t=13.263，18.600和16.645，均P<0.001 5）。随访12个月后患者死亡45例（37.50%），高Klotho，UMOD水平组不良预后风险低于低Klotho，UMOD水平组，高HE4水平组不良预后风险高于低HE4水平组，差异均有统计学意义（χ2=4.511，3.960，7.484；P=0.034，0.047，0.006）。结论　慢性肾病患者血清中Klotho，HE4，UMOD均存在异常表达，其中血清Klotho，UMOD水平降低以及HE4水平升高可增加肾功能恶化风险，三种血清因子联合可提高对预后评估的参考价值。

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备注/Memo

备注/Memo:
基金项目：陕西省科技厅社会发展项目（2020SF-167）。
作者简介：赵智凝（1975-），女，博士，主治医师，研究方向：临床检验，E-mail：shirley_zzn@sina.com。
更新日期/Last Update: 2021-04-10