[1]刘 飞,陈静非.2型糖尿病患者IL-18基因启动子区-607C/A和-137G/C位点多态性与颈动脉粥样硬化的相关性研究[J].现代检验医学杂志,2021,36(02):57-60.[doi:doi:10.3969/j.issn.1671-7414.2021.02.014]
 LIU Fei,CHEN Jing-fei.Correlation between -607C/A and -137G/C Polymorphisms in the IL-18 Promoter Region and Carotid Atherosclerosis in Type 2 Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2021,36(02):57-60.[doi:doi:10.3969/j.issn.1671-7414.2021.02.014]
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2型糖尿病患者IL-18基因启动子区-607C/A和-137G/C位点多态性与颈动脉粥样硬化的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
57-60
栏目:
论 著
出版日期:
2021-04-30

文章信息/Info

Title:
Correlation between -607C/A and -137G/C Polymorphisms in the IL-18 Promoter Region and Carotid Atherosclerosis in Type 2 Diabetes Mellitus
文章编号:
1671-7414(2021)02-057-04
作者:
刘 飞陈静非
(宝鸡市中心医院a.综合内科;b.神经内科一科,陕西宝鸡 721000)
Author(s):
LIU Fei CHEN Jing-fei
( a. Department of General Medicine; b. the First Department of Neurology, Baoji Central Hospital, Shaanxi Baoji 721000, China)
关键词:
2型糖尿病(T2DM)白细胞介素-18(IL-18)颈动脉内-中膜厚度(CIMT)颈动脉粥样硬化(CAS)
分类号:
R587.1;R543.4;Q786
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.014
文献标志码:
A
摘要:
目的 探讨2型糖尿病(type 2 diabetes mellitus, T2DM)患者IL-18基因启动子区-607C/A和-137G/C位点多态性与颈动脉粥样硬化(carotid atherosclerosis, CAS)的相关性研究。方法 收集2018年1月~2019年12月宝鸡市中心医院收治的375例T2DM患者为研究对象并记为T2DM组,另选择同期该院体检健康的200例志愿者作为对照组,T2DM组患者再根据颈部血管超声结果分为颈动脉内-中膜厚度(carotid intima-media thickness, CIMT)正常组(n=122)和CIMT增厚组(n=253)。采用聚合酶链式反应(polymerase chain reaction, PCR)法检测IL-18基因启动子区-607C/A和-137G/C位点基因型。分别比较各组两位点基因型和等位基因型的分布频率。采用Logistic回归分析法分析T2DM患者CIMT增厚的独立危险因素。结果 对照组和T2DM组的BMI,CIMT和高血压差异具有统计学意义(t=5.270,Z=16.038,χ2=6.261,P<0.05),两组吸烟和血脂异常的差异无统计学意义 (χ2=0.800,1.991,均P>0.05)。CIMT正常组和CIMT增厚组在吸烟、CIMT,糖尿病病程方面的差异具有统计学意义 (χ2=5.302,Z=15.694,12.057,均P<0.05),两组BMI,高血压和血脂异常的差异无统计学意义 (χ2=0.567,0.741,3.133,均P>0.05)。对照组和T2DM组IL-18基因启动子区-607C/A和-137G/C位点基因型和等位基因型分布频率的差异无统计学意义(χ2=1.654,4.939,1.742,2.812,均P>0.05)。CIMT正常组和CIMT增厚组IL-18基因启动子区-607C/A和-137G/C位点基因型和等位基因型分布频率的差异均具有统计学意义(χ2=11.410,11.957,均P<0.05),两组-137G/C位点基因型和等位基因型分布频率的差异均无统计学意义(χ2=3.696,2.931,均P>0.05)。采用Logistic回归分析法结果显示糖尿病病程和-607C/A(CC vs CA+AA)基因型是T2DM患者CIMT增厚的独立危险因素。结论 T2DM患者中IL-18基因启动子区-607C/A位点多态性与CAS密切相关。

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:刘飞(1988-),男,硕士,主治医师,研究方向:内科学,E-mail: liufeiloveyou1988@126.com。
通讯作者:陈静非(1987-),女,硕士,主治医师,研究方向:脑血管病,E-mail: baijichenjf87@163.com。
更新日期/Last Update: 2021-04-10