[1]曹阳阳,樊阳阳,宋秀英,等.多囊卵巢综合征患者血清镍纹样蛋白水平检测的临床意义及与实验室指标的相关性研究[J].现代检验医学杂志,2021,36(02):111-113.[doi:doi:10.3969/j.issn.1671-7414.2021.02.026]
　CAO Yang-yang,FAN Yang-yang,SONG Xiu-ying,et al.Clinical Significance of Serum Metrnl Protein Level Detection in Patients with Polycystic Ovary Syndrome and Its Correlation with Laboratory Indexes[J].Journal of Modern Laboratory Medicine,2021,36(02):111-113.[doi:doi:10.3969/j.issn.1671-7414.2021.02.026]
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多囊卵巢综合征患者血清镍纹样蛋白水平检测的临床意义及与实验室指标的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
111-113
栏目:
论　著
出版日期:
2021-04-30

文章信息/Info

Title:
Clinical Significance of Serum Metrnl Protein Level Detection in Patients with Polycystic Ovary Syndrome and Its Correlation with Laboratory Indexes
文章编号:
1671-7414（2021）02-111-04
作者:
曹阳阳; 樊阳阳; 宋秀英; 等
(1.西安高新医院妇产科，西安 710075；2.陕西省人民医院产科，西安 710068)
Author(s):
CAO Yang-yang;  FAN Yang-yang;  SONG Xiu-ying;  et al
(1.Department of Gynaecology and Obstetrics, Xi’an Gaoxin Hospital, Xi’an 710075, China;2.Department of Obstetrics, Shaanxi Provincial People’s Hospital, Xi’an 710068, China)
关键词:
多囊卵巢综合征; 镍纹样蛋白; 实验室指标
分类号:
R711.75；R446.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.026
文献标志码:
A
摘要:
目的　探究多囊卵巢综合征(polycystic ovary syndrome, PCOS)患者血清镍纹样蛋白(meteorin-like protein, Metrnl)水平检测的临床意义及与实验室指标的相关性。方法　 选取2018年4月～2019年9月西安高新医院妇科收治的61例PCOS患者为观察组，另选取同期58例健康体检女性作为对照组。应用全自动生化分析仪检测两组的总胆固醇(total cholesterol, TC)、三酰甘油(triglyceride, TG)、空腹血糖(fasting blood glucose, FBG)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、游离睾酮(free testosterone, FT)、卵泡刺激素(follicle-stimulating hormone, FSH)和促黄体生成素(luteinizing hormone, LH)等水平。采用酶联免疫吸附法(ELISA)检测血清中Metrnl的水平。相关性分析采用Spearson相关性检验。比较两组的实验室指标，正常和肥胖人群中血清Metrnl水平，分析Metrnl表达水平与实验室指标的相关性。结果　两组的FBG，TC，低密度脂蛋白胆固醇(low density lipoprotein-cholesterin, LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein-cholesterol, HDL-C)等实验室指标差异均无统计学意义(t=0.12，1.95，0.87，0.48，均P>0.05)，观察组的hs-CRP和FT水平高于对照组，观察组的Metrnl (98.4±32.2 pg/ml)显著高于对照组(65.3±27.7 pg/ml)，差异具有统计学意义(t=5.36，13.20，5.91，均P<0.05)。对照组中正常(18.5 kg/m2≤BMI<24 kg/m2)和肥胖(BMI≥24 kg/m2)人群血清Metrnl水平差异无统计学意义(t=3.70，P>0.05)。观察组中肥胖人群血清Metrnl水平显著高于正常人群，差异具有统计学意义(t=11.41，P＜0.05)。Metrnl表达水平与hs-CRP，FT和BMI呈正相关关系(r=0.507，0.309和0.391，均P =0.000)。结论　Metrnl可作为PCOS潜在的生物学标记物，其表达水平与患者的hs-CRP，FT和BMI呈正相关。

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备注/Memo

备注/Memo:
作者简介：曹阳阳（1986-），女，本科，主治医师，研究方向:妇产科疾病的诊疗，E-mail: xiancaoyangyang@163.com。
通讯作者：宋秀英（1983-），女，本科，主治医师，研究方向：妇产科疾病的诊疗，E-mail: gaoxinsongxiuy@163.com。
更新日期/Last Update: 2021-04-10