[1]郝玉萍,薛金莲,樊阳阳,等.孕妇血清生物素水平与胎儿生长及早产的相关性分析[J].现代检验医学杂志,2021,36(02):148-150.[doi:doi:10.3969/j.issn.1671-7414.2021.02.035]
 HAO Yu-ping,XUE Jin-lian,FAN Yang-yang,et al.Analysis of Correlation between Serum Biotin Level and Fetal Growth and Premature Delivery in Pregnant Women[J].Journal of Modern Laboratory Medicine,2021,36(02):148-150.[doi:doi:10.3969/j.issn.1671-7414.2021.02.035]
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孕妇血清生物素水平与胎儿生长及早产的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
148-150
栏目:
检验与临床
出版日期:
2021-04-30

文章信息/Info

Title:
Analysis of Correlation between Serum Biotin Level and Fetal Growth and Premature Delivery in Pregnant Women
文章编号:
1671-7414(2021)02-148-03
作者:
郝玉萍薛金莲樊阳阳
(1.铜川市人民医院新生儿科, 陕西铜川 727031;2.山东省日照市中心医院儿科,山东日照 276800;3. 陕西省人民医院产科,西安 710068)
Author(s):
HAO Yu-ping XUE Jin-lian FAN Yang-yang et al
(1. Department of Neonatology, Tongchuan People’s Hospital, Shaanxi Tongchuan 727031, China;2.Pediatrics Department, Rizhao Central Hospital, Shandong Rizhao 276800, China; 3.Department of Obstetrics, Shaanxi People’s Hospital, Xi’an 710068, China)
关键词:
孕妇生物素胎儿胎龄
分类号:
R714.21;R446.112
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.035
文献标志码:
A
摘要:
目的 探究孕妇血清生物素水平与胎儿生长及早产的相关性。方法 选取铜川市人民医院自2019年1月~10月收治的90例孕妇为观察组。另选取同期该院体检健康且未怀孕女性90例作为对照组。观察组根据妊娠时期的不同分为早、中、晚期妊娠。观察组根据妊娠结局的不同分为足月儿组、早产儿组和小于胎龄儿(Substantial gainful activity,SGA)组,比较足月儿组、早产儿组和SGA组的平均年龄、身体质量指数(Body Mass Index, BMI)和初产。通过酶联免疫吸附法(ELISA)检测外周血血清和脐带血血清中生物素的水平,采用Pearson 相关分析探究生物素水平与胎儿生长及早产的相关性。结果 妊娠孕妇血清中生物素水平在妊娠初期至晚期保持较低水平,且显著低于对照组(F=14.39,P<0.001)。足月儿组脐带血血清中生物素水平高于早产儿组和SGA组,其组间差异具有统计学意义(F=70.387,P<0.001)。足月儿组外周血血清中生物素水平高于早产儿组和SGA组,其组间差异不具有统计学意义(F=1.294,P=0.279)。足月儿组、早产儿组和SGA组脐带血血清中生物素水平高于外周血,其差异均具有统计学意义(t=4.214~12.188,均P<0.001)。Pearson 相关分析结果显示血清中生物素水平与胎儿胎龄呈正相关关系(r=0.32,P=0.01)。结论 怀孕期间孕妇可适当补充生物素以预防胎儿生长的异常。

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备注/Memo

备注/Memo:
作者简介:郝玉萍(1978-),女,本科,副主任医师,研究方向:儿科相关疾病的诊疗,E-mail:tongchaoyup1978@163.com。
通讯作者:李延芳(1987-),女,本科,主治医师,研究方向:儿科相关疾病的诊疗,E-mail:907248565@qq.com。
更新日期/Last Update: 2021-04-10