[1]谭清亚a,牟方红a,饶文明a,等.急性肺栓塞患者血清ADAM15 和MMP-2 表达水平及其与疾病严重程度的相关性研究[J].现代检验医学杂志,2023,38(04):186-190.[doi:10.3969/j.issn.1671-7414.2023.04.034]
　TAN Qingyaa,MOU Fanghonga,RAO Wenminga,et al.Study on the Expression of Serum ADAM15 and MMP-2 in Patients with Acute Pulmonary Embolism and Their Correlation with Disease Severity[J].Journal of Modern Laboratory Medicine,2023,38(04):186-190.[doi:10.3969/j.issn.1671-7414.2023.04.034]
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急性肺栓塞患者血清ADAM15 和MMP-2 表达水平及其与疾病严重程度的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年04期
页码:
186-190
栏目:
检验与临床
出版日期:
2023-07-15

文章信息/Info

Title:
Study on the Expression of Serum ADAM15 and MMP-2 in Patients with Acute Pulmonary Embolism and Their Correlation with Disease Severity
文章编号:
1671-7414（2023）04-186-05
作者:
谭清亚a; 牟方红a; 饶文明a; 张春光b
（重庆市开州区人民医院a. 呼吸与危重症医学科；b. 胸心腹壁疝外科，重庆 405400）
Author(s):
TAN Qingyaa;  MOU Fanghonga;  RAO Wenminga;  ZHANG Chunguangb
（a.Department of Respiratory and Critical Care Medicine；b. Department of Thoracoabdominal Hernia Surgery, Chongqing Kaizhou District People’s Hospital, Chongqing 405400, China）
关键词:
急性肺栓塞; 解整合素金属蛋白酶15; 基质金属蛋白酶2; 疾病严重程度
分类号:
R563.5；R392.11
DOI:
10.3969/j.issn.1671-7414.2023.04.034
文献标志码:
A
摘要:
目的　探讨血清解整合素金属蛋白酶15（disintegrin and metalloproteinase 15，ADAM15）和基质金属蛋白酶2（matrix metalloproteinase 2，MMP-2）表达水平与急性肺栓塞患者疾病严重程度的关系及其诊断价值。方法　收集重庆市开州区人民医院2020 年1 月～ 2021 年11 月期间入院的116 例急性肺栓塞患者，根据疾病严重程度将其分为中高危组（n=62）、低危组（n=54），同期选取体检健康者64 例为对照组。检测血清ADAM15，MMP-2，C 反应蛋白和D-二聚体水平；Pearson 法分析ADAM15，MMP-2 与C 反应蛋白和D- 二聚体的相关性；受试者工作特征（ROC）曲线分析血清ADAM15 和MMP-2 水平对急性肺栓塞危险分层的价值；多因素Logistic 回归分析影响急性肺栓塞患者疾病严重程度的因素。结果　中高危组血清ADAM15（718.75±146.43 pg/ml），MMP-2（3.62±1.04 μg/L），C反应蛋白（36.45±7.04mg/L）和D- 二聚体（5.18±1.34 mg/L）高于低危组（543.72±110.95 pg/ml，2.04±0.62 μg/L，9.97±3.04 mg/L，2.06±0.47mg/L）和对照组（412.54±85.14 pg/ml，1.10±0.36 μg/L，1.68±0.44 mg/L，0.32±0.08 mg/L），差异均有统计学意义（F=108.644 ～ 1 029.59，均P ＜ 0.05）。ADAM15 和MMP-2 及二者联合诊断低危急性肺栓塞的曲线下面积（areaunder curve，AUC）分别为0.797，0.753 和0.859。ADAM15 和MMP-2 及二者联合诊断中高危急性肺栓塞的AUC 分别为0.851，0.756 和0.878。急性肺栓塞患者血清ADAM15 与MMP-2 呈正相关（r=0.520，P ＜ 0.05），二者与C 反应蛋白、D-二聚体均呈正相关（r=0.482，0.474；0.479，0.486，均P ＜ 0.05）。ADAM15（OR=2.335，P=0.002），MMP-2（OR=2.249，P=0.006）是急性肺栓塞患者疾病发展为中高危的独立危险因素。结论　血清ADAM15 和MMP-2 可有效诊断不同疾病严重程度急性肺栓塞，可作为急性肺栓塞危险分层的辅助指标。
Abstract:
Objective　To investigate the relationship between the levels of serum disintegrin and ADAM15 and MMP-2 and the severity of disease in patients with acute pulmonary embolism and the diagnostic value. Methods　From January 2020 to November 2021, 116 patients with acute pulmonary embolism hospitalized in Chongqing Kaizhou District People’s Hospital were gathered. According to the severity of the disease, they were separated into the middle-high-risk group（n=62）and the low-risk group（n=54）. Meantime, 64 healthy people for physical examination were gathered as the control group. The levels of ADAM15, MMP-2 , C-reactive protein and D-dimer were measured. The correlation between serum ADAM15, MMP-2, C-reactive protein and D-dimer was analyzed by Pearson method. The value of serum ADAM15 and MMP-2 levels in the risk stratification of acute pulmonary embolism was analyzed using the subject working characteristic (ROC) curve. And the factors affecting the severity of acute pulmonary embolism were analyzed by multivariate Logistic regression. Results　Serum ADAM15 (718.75 ± 146.43 pg/ml), MMP-2 (3.62 ± 1.04 μ g/L), C-reactive protein (36.45 ± 7.04 mg/L), D-dimer (5.18 ± 1.34 mg/L) were higher than those in lower risk group (543.72 ± 110.95 pg/ml, 2.04 ± 0.62 μ g/L, 9.97 ± 3.04 mg/L, 2.06 ± 0.47 mg/L) and control group (412.54 ± 85.14 pg/ml, 1.10 ± 0.36 μ g/L, 1.68 ± 0.44 mg/L, 0.32 ± 0.08 mg/L), with statistically significant difference (F=108.644 ～ 1029.59 , all P<0.05). The AUC of ADAM15, MMP-2 and their combined diagnosis for low-risk acute pulmonary embolism was 0.797, 0.753 and 0.859, respectively, and the AUC of ADAM15, MMP-2 and their combined diagnosis for high-risk acute pulmonary embolism was 0.851, 0.756 and 0.878, respectively. The serum ADAM15 was positively correlated with MMP-2 in patients with acute pulmonary embolism (r=0.520, P<0.05), and both were positively correlated with C-reactive protein and D-dimer (r=0.482，0.474; 0.479, 0.486, all P<0.05). ADAM15 (OR=2.335, P=0.002) and MMP-2 (OR=2.249, P=0.006) were independent risk factors for the development of acute pulmonary embolism into middle and high risk. Conclusion　Serum ADAM15 and MMP-2 could effectively diagnose acute pulmonary embolism of different disease severity and it could be used as an auxiliary indicator for risk stratification of acute pulmonary embolism.

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备注/Memo

备注/Memo:
作者简介： 谭清亚（1988-），女，本科，主治医师，主要从事呼吸内科，肺炎、慢性阻塞性肺病、肺癌等相关研究，E-mail：tanqingya368@163.com。
更新日期/Last Update: 2023-07-15