[1]安伟乔,张绍义,范红娟,等.老年心力衰竭并发肺炎患者血清FOXM1 和IGF2 表达水平及与预后价值研究[J].现代检验医学杂志,2024,39(02):146-150.[doi:10.3969/j.issn.1671-7414.2024.02.027]
　AN Weiqiao,ZHANG Shaoyi,FAN Hongjuan,et al.Study on Serum FOXM1 and IGF2 Expression Levels and Prognostic Value in Elderly Patients with Heart Failure Complicated with Pneumonia[J].Journal of Modern Laboratory Medicine,2024,39(02):146-150.[doi:10.3969/j.issn.1671-7414.2024.02.027]
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老年心力衰竭并发肺炎患者血清FOXM1 和IGF2 表达水平及与预后价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年02期
页码:
146-150
栏目:
论著
出版日期:
2024-03-31

文章信息/Info

Title:
Study on Serum FOXM1 and IGF2 Expression Levels and Prognostic Value in Elderly Patients with Heart Failure Complicated with Pneumonia
文章编号:
1671-7414（2024）02-146-05
作者:
安伟乔; 张绍义; 范红娟; 王辉
（邯郸市中心医院老年病一科，河北邯郸 056000）
Author(s):
AN Weiqiao;  ZHANG Shaoyi;  FAN Hongjuan;  WANG Hui
（Department of Geriatrics, Handan Central Hospital, Hebei Handan 056000, China）
关键词:
心力衰竭并发肺炎; 叉头盒蛋白M1; 胰岛素样生长因子2
分类号:
R541.6；R392.11
DOI:
10.3969/j.issn.1671-7414.2024.02.027
文献标志码:
A
摘要:
目的 探究血清叉头盒蛋白M1（forkhead box protein M1，FOXM1）和胰岛素样生长因子2（insulin-likegrowth factor 2，IGF2）表达对老年心力衰竭合并肺炎患者预后的预测价值。方法 将邯郸市中心医院2021 年3 月~2022 年6 月收治的126 例老年心力衰竭并发肺炎患者设为病例组，并根据随访情况将122 例患者分为预后不良组（n=33）和预后良好组（n=89），另选取该院同期126 例健康体检者为对照组。检测两组（病例组和对照组）血清FOXM1 和IGF2 水平，检测病例组用力肺活量（forced vital capacity，FVC）和第一秒用力呼容积（forced expiratory volume in onesecond，FEV1）。采用Spearman 分析法分析老年心力衰竭并发肺炎患者血清FOXM1和IGF2 水平与心功能分级的相关性；受试者工作特征（receiver operating characteristic，ROC）曲线分析血清FOXM1 和IGF2 水平对老年心力衰竭并发肺炎患者预后的预测价值。结果 与对照组比较，病例组血清FOXM1（2.39 ± 0.55 vs 1.06 ± 0.21）和IGF2（71.33 ± 7.96pg/ml vs 47.82 ± 5.14pg/ml）水平明显较高，差异有统计学意义（t=25.358，27.581，均P ＜ 0.05）；与预后良好组比较，预后不良组血清FOXM1（3.87 ± 1.06 vs 1.95 ± 0.51）和IGF2 水平（85.88 ± 9.54pg/ml vs 69.14 ± 8.73pg/ml）明显较高，差异具有统计学意义（t=13.453，9.174，均P ＜ 0.05）；预后良好组和预后不良组心功能分级比较差异有统计学意义（χ2=7.120，P ＜ 0.05），且与预后不良组比较，预后良好组FEV1（1.24 ± 0.32L vs 1.08 ± 0.25L）和FEV1/FVC（55.46%± 5.77% vs 52.30 %± 5.38%）明显较高，差异有统计学意义（t=2.592，2.735，均P ＜ 0.05）；老年心力衰竭并发肺炎患者血清FOXM1 水平和IGF2 水平与心功能分级呈显著正相关（r=0.496，0.517，均P ＜ 0.05）。ROC 曲线结果显示，血清FOXM1 单独预测老年心力衰竭并发肺炎患者预后的曲线下面积（area under the curve，AUC）为0.854（95CI%：0.779~0.912），其敏感度、特异度分别为75.76%，86.52%，最佳截断值为2.75；IGF2 单独预测老年心力衰竭并发肺炎患者预后的AUC 为0.874（95CI%：0.802~0.927），其敏感度、特异度分别为72.73%，85.39%，最佳截断值为 78.30pg/ml；二者联合预测老年心力衰竭并发肺炎患者预后的AUC 显著大于血清FOXM1 和IGF2 单独诊断的AUC（Z=2.413，2.737，P=0.006，0.016）。结论 血清FOXM1 和IGF2 水平在老年心力衰竭并发肺炎患者中升高，且二者联合检测对患者预后具有较高的预测价值。
Abstract:
Objective To explore the predictive value of the expression of serum forkhead box protein M1 (FOXM1) and insulinlike growth factor 2 (IGF2) on the prognosis of elderly patients with heart failure complicated with pneumonia. Methods A total of 126 elderly patients with heart failure complicated with pneumonia admitted to Handan Central Hospital from March 2021 to June 2022 were included in case group. According to the follow-up results, the 122 patients were grouped into poor prognosis group (n=33) and good prognosis group (n=89). Meanwhile, 126 healthy people in the same period were included as the control group. The levels of serum FOXM1 and IGF2, forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) in the two groups (case group and control group) were measured. Spearman method was used to analyze the correlation between serum levels of FOXM1 and IGF2 and heart function classification in elderly patients with heart failure complicated with pneumonia. The predictive value of serum FOXM1 and IGF2 levels in elderly patients with heart failure complicated with pneumonia was analyzed by receiver operating characteristic (ROC) curve. Results Compared with the control group, the levels of FOXM1 (2.39 ± 0.55 vs 1.06 ± 0.21) and IGF2 (71.33 ± 7.96pg/ml vs 47.82 ± 5.14pg/ml) in the case group were significantly higher (t=25.358, 27.581, all P < 0.05). Compared with the good prognosis group, the levels of serum FOXM1 (3.87 ± 1.06 vs 1.95 ± 0.51) and IGF2 (85.88 ± 9.54pg/ml vs 69.14 ± 8.73pg/ml) in the poor prognosis group were significantly higher，and the differences were statistically significant (t=13.453, 9.174, all P < 0.05). There were significant differences in heart function classification between the good prognosis group and the poor prognosis group，and the differences were statistically significant (χ2=7.120, P < 0.05). Compared with the poor prognosis group, FEV1 (1.24 ± 0.32 L vs 1.08 ± 0.25 L) and FEV1/FVC (55.46% ± 5.77% vs 52.30 %± 5.38%) in good prognosis group were significantly higher ，and the differences were statistically significant (t=2.592, 2.735, all P < 0.05). The levels of serum FOXM1 and IGF2 (r=0.496, 0.517, all P<0.05) in elderly patients with heart failure complicated with pneumonia were positively correlated with heart function classification. ROC curve results showed that the area under the curve (AUC) of serum FOXM1 alone in predicting the prognosis of elderly patients with heart failure complicated with pneumonia was 0.854 (95CI%: 0.779~0.912), with sensitivity and specificity of 75.76% and 86.52%, respectively, and the optimal cut-off value of 2.75. The AUC of IGF2 alone in predicting the prognosis of elderly patients with heart failure complicated with pneumonia was 0.874 (95CI%: 0.802~0.927), with sensitivity and specificity of 72.73% and 85.39%, respectively, and the optimal cut-off value of 78.30 pg/ml. The AUC of the combination of the two in predicting the prognosis of elderly patients with heart failure complicated with pneumonia was greater than the AUC diagnosed by serum FOXM1 alone and IGF2 alone (Z=2.737, 2.413, P=0.006, 0.016). Conclusion The serum levels of FOXM1 and IGF2 were increased in elderly patients with heart failure complicated with pneumonia, indicating the combined detection of the two may have a high predictive value for the prognosis of patients.

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备注/Memo

备注/Memo:
作者简介：安伟乔（1983-），女，硕士研究生，副主任医师，研究方向：老年心衰，E-mail：tsr2ipa@163.com。
通讯作者：范红娟（1977-），女，硕士研究生，副主任医师，研究方向：老年心衰，E-mail：hunhuanghpx6@163.com。
更新日期/Last Update: 2024-03-15