[1]李德璇,王玉明,杨红玲,等.亲环素A与慢性心力衰竭相关性的研究[J].现代检验医学杂志,2015,30(01):31-33.[doi:10.3969/j.issn.1671-7414.2015.01.009]
　LI De-xuan,WANG Yu-ming,YANG Hong-ling,et al.Study on the Relationship between Cyclophilin A and Chronic HeartFailure[J].Journal of Modern Laboratory Medicine,2015,30(01):31-33.[doi:10.3969/j.issn.1671-7414.2015.01.009]
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亲环素A与慢性心力衰竭相关性的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
31-33
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Study on the Relationship between Cyclophilin A and Chronic HeartFailure
文章编号:
1671-7414(2015)01-031-03
作者:
李德璇1; 王玉明2; 杨红玲1; 李亚山1; 徐正良1; 胡 滔1
1.云南省第三人民医院检验科,昆明 650034;
2.昆明医科大学第一附属医院检验科,昆明 650032
Author(s):
LI De-xuan1; WANG Yu-ming2; YANG Hong-ling1; LI Ya-shan1; XU Zheng-liang1; HU Tao1
1.Department of Clinical Laboratory,the Third People's Hospital of Yunnan Province,Kunming 650034,China;
2.Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China
关键词:
慢性心力衰竭;  亲环素A;  N端B型钠尿肽前体
分类号:
R541.6; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.01.009
文献标志码:
A
摘要:
目的 探讨亲环素A(CyP A)在慢性心力衰竭中的诊断意义。方法 选择经临床确诊的慢性心力衰竭患者80例,分为心衰A期30例、心衰C期29例、心衰D期21例。同时选择健康体检者30例作为对照组。采用ELISA方法测定CyP A的含量,采用罗氏电化学发光法检测NT-proBNP的含量。结果 健康对照组及慢性心衰各组CyP A浓度((-overx)&#177;s,ng/ml)分别为110.10±49.73,327.85±82.67,331.70±69.34和342.46±92.55。采用单因素方差分析,慢性心衰患者CyP A浓度显著高于健康对照组(F=58.45,P<0.01)。进一步采用LSD检验进行组间两两比较,慢性心衰各组均显著高于健康对照组(均值差217.75～232.36,P值均<0.01),但慢性心衰各组间的差异无统计学意义(均值差3.37～14.61,P值均>0.05)。ROC曲线显示,CyP AAUC=0.97,最佳临界值为198.39(ng/ml),其灵敏度为91.30%,特异度93.30%。相关性分析显示CyP A与NT-proBNP存在显著相关性(r=0.30,P<0.01)。CyP A与proBNP联合检测诊断心衰灵敏度为93.80%,特异度为100%。结论 CyP A在慢性心力衰竭患者中高表达,提示Cyp A可能是CHF的一个显现因子,其与NT-proBNP联合检测可能有助于心衰的诊断。
Abstract:
Objective To investigate the diagnosticvalue of cyclophilin A(CyPA)for chronic heart failure(CHF).MethodsEighty pateints,made a definite diagnosis as CHF,were classified30 cases as A phase,29 cases as C phase,21 cases as D phase of them.30 healthy subjects were enrolled in this study.Serum CyP A was detcted by ELISA.NT-proBNP was detected with Roche Cobas 6 000 automatic electrochemilu- minescence immunoassay system.Results The amounts of serum CyP A((-overx)&#177;s,ng/ml)in healthy subjects and each group with CHF were 110.10±49.73, 327.85±82.67,331.70±69.34 and 342.46±92.55.Using Oneway Anova,CyP A concentration of CHF was significantly higher than healthy controls(F= 58.45,P<0.01).Further using Post Hoc Tests-Multiple Comparisons,the CyP A concentration of each group with CHF was significantly higher than the healthy control group(Mean differences were 217.75～232.36,P<0.01),but showed no significant difference between the groups with CHFs(Mean differences were 3.37～14.61,P>0.05).Results of ROC curves showed the AUC(CyP A)was0.97.The best cutoff value was 198.39(ng/ml).The sensitivity was 91.30%,the specificity was 93.30%.The correlation analysis showed that CyP A and NT-proBNP were correlated(r=0.30,P<0.01).CyP A and NT-proBNP combined detections showed the sensitivity was 93.80% and the specificity was 100%.Conclusion The Cyp A levels in CHF group are significantly higher than the control group,suggesting that Cyp A may be a factor for CHF appearance.These results indicate that combined detections may helpful to early diagnosis of CHF.

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备注/Memo

备注/Memo:

作者简介:李德璇(1983-),女,硕士,主管技师,主要从事临床检验工作,E-mail:147347278@qq.com。
通讯作者:王玉明,主任医师,E-mail:wangym992007@163.com。
更新日期/Last Update: 2015-01-30