[1]汪隆海a,陈启松b,夏 芳a,等.和肽素与大内皮素-1及N末端 脑钠肽对心力衰竭的预后价值[J].现代检验医学杂志,2015,30(01):64-67.[doi:10.3969/j.issn.1671-7414.2015.01.017]
　WANG Long-haia,CHEN Qi-songb,XIA Fanga,et al.Prognostic Value of Copeptin,Big Endothelin-1 and N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(01):64-67.[doi:10.3969/j.issn.1671-7414.2015.01.017]
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和肽素与大内皮素-1及N末端 脑钠肽对心力衰竭的预后价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
64-67
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Prognostic Value of Copeptin,Big Endothelin-1 and N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Heart Failure
文章编号:
1671-7414(2015)01-064-05
作者:
汪隆海a; 陈启松b; 夏 芳a; 方 超a; 何海军b; 张 平c
安徽省含山县人民医院a.检验科;
b.心内科;
c.彩超室,安徽含山238100
Author(s):
WANG Long-haia; CHEN Qi-songb; XIA Fanga; FANGChaoa; HE Hai-junb; ZHANG Pingc
a.Department of Clinical Laboratory;
b.Department ofCardiology;
c.Room of Ultrasonic Diagnosis,the People's Hospital of Hanshan County,Anhui Hanshan 238100,China
关键词:
和肽素;  内皮素;  脑钠肽;  心力衰竭;  充血性;  预后
分类号:
R541.6; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.01.017
文献标志码:
A
摘要:
目的 通过对心力衰竭患者的随访研究,探讨和肽素与大内皮素-1(Big ET-1)及N末端脑钠肽(NT-proBNP)对心力衰竭患者的预后价值。方法 研究159例心力衰竭住院患者,检测入院时血清和肽素,NT-proBNP,肌钙蛋白I,CKMB和血浆Big ET-1与左室射血分数以及NYHA分级。并随访观察患者出院后360～490天的心血管事件再发生情况。结果 159例心力衰竭患者的中位随访385天,发生心脏事件65例。多元典型相关分析显示心力衰竭患者的年龄越大和NYHA分级越高及LVEF越低,则心力衰竭患者的和肽素与Big ET-1及NT-proBNP的浓度越高。Cox比例风险模型分析显示,年龄、和肽素和Big ET-1及NT-proBNP是独立的心脏事件再发生的预后因素,风险比分别为1.215,1.236,4.031和13.052。logistic回归分析显示,和肽素与Big ET-1及NT-proBNP是独立的心源性死亡的危险因素,优势比分别为4.003,2.477和1.235。结论 检测和肽素与Big ET-1及NT-proBNP可对心衰患者进行心脏事件再发生的危险分层和预后分析。
Abstract:
Objective To investigate the prognostic factorsfor chronic heart failure and the prognostic ability of copeptin,big endothelin-1(Big ET-1)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in patients with chronic heart failure.Methods To study 159 consecutive patients hospitalized for chronic heart failure.Serum concentrationof copeptin,NT-proBNP,cTnI,CKMB and plasma Big ET-1 as well as left ventricular ejection fraction(LVEF)and NYHA class Ⅰto Ⅳ on admission were measured.Cardiac events were found by patients to discharge after 360～490 days,prospectively.Results During a median follow-up period of 385days,the endpoint of recurrence for cardiac events was reached in 65 patients with 159 heart failure.Multivarlate canonical correlation analysis shows the older and the higher NYHA classification as well as the lower LVEF in patients withheart failure.There were higher concentration of copeptin,Big ET-1 and NT-proBNP.On a Cox proportional hazards regression models analyses,age,copeptin,Big ET-1 and NT-proBNP were found to be the independent predictors of cardiacevents.Risk ratio(RR)were 1.215,1.236,4.031 and 13.052,respectively.Logistic regression models analyses,copeptin,Big ET-1 and NT-proBNP were found independent predictors of death.Odd ratio(OR)were 4.003,2.477 and 1.235,respectively.Conclusion Measurement of copeptin,Big ET-1 and NT-proBNP in patients with chronic heart failure can help to identifypatients at higher risk for cardiac events and patients for prognosis.

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备注/Memo

备注/Memo:

作者简介:汪隆海(1957-),男,大专,副主任检验师,科主任,从事临床化学检验工作与研究,Tel:15905651906,E-mail:wlhgh@126.com。
更新日期/Last Update: 2015-01-30