[1]刘 莎,江咏梅,张 鸽,等.两种试剂D-二聚体检测值 与纤维蛋白降解产物值的相关性研究[J].现代检验医学杂志,2015,30(01):108-110.[doi:10.3969/j.issn.1671-7414.2015.01.030]
　LIU Sha,JIANG Yong-mei,ZHANG Ge,et al.Study of the Correlation of Testing Results by Two Different D-dimer Reagents with Fibrin Degradation Products Result Values[J].Journal of Modern Laboratory Medicine,2015,30(01):108-110.[doi:10.3969/j.issn.1671-7414.2015.01.030]
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两种试剂D-二聚体检测值 与纤维蛋白降解产物值的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
108-110
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Study of the Correlation of Testing Results by Two Different D-dimer Reagents with Fibrin Degradation Products Result Values
文章编号:
1671-7414(2015)01-108-03
作者:
刘 莎; 江咏梅; 张 鸽; 崔亚利
四川大学华西第二医院,成都 610041
Author(s):
LIU Sha; JIANG Yong-mei; ZHANG Ge; CUI Ya-li
West China Second Hospital of Sichuan University,Chengdu 610041,China
关键词:
D-二聚体;  纤维蛋白降解产物P;  Siemens D-Dimer Plus试剂;  Innovance D-DIMER试剂
分类号:
R446.62
DOI:
10.3969/j.issn.1671-7414.2015.01.030
文献标志码:
A
摘要:
目的 通过研究两种不同试剂D-二聚体(D-DIMER)检测值与纤维蛋白降解产物(fibrin degradation products,FDP)的相关性,分析检测值的吻合度,评价两种检测试剂的临床实用性。方法 采用Sysmex CA-1500全自动血凝分析仪检测患者D-二聚体及FDP,D-二聚体检测试剂分别为Siemens Innovance D-DIMER和Dade Behring D-Dimer Plus。回顾性研究762例临床患者标本D-二聚体及FDP测定结果,并将测定结果进行等级频数分析及等级相关检验(Spearman法)。结果Siemens Innovance D-DIMER试剂检测同一患者D-二聚体值与FDP水平呈正相关(r=0.954,P<0.01),优于Siemens DD Plus试剂(r=0.885,P<0.01),且这种相关性随D-二聚体含量的升高而升高,当D-二聚体>5 mg/L FEU时,相关性达到最佳(P<0.01)。Innovance D-DIMER试剂组FDP阳性率(约为65.76%)相对于DD Plus试剂组(91.48%)偏低,提示Innovance D-DIMER试剂组D-二聚体能够在FDP升高之前出现反应,具有更高的灵敏度。结论 使用Siemens Innovance D-DIMER试剂检测D-二聚体并结合FDP值可以为临床提供更加确切的疾病诊治信息。
Abstract:
Objective To evaluate the clinical practicalityof two different D-dimer assays by studying the correlation of the testing results by two different D-dimer reagents with fibrin degradation products(FDP)result values and analyzing the Clinical alignment.Methods A representative cross-sectional study of 762 clinical patients' plasma specimens were taken to measure the results of D-dimer and FDP by using Sysmex CA-1500 automated coagulation analyzer,D-DIMER detection reagent respectively Siemens Innovance D-DIMER and Dade Behring D-DIMER Plus reagents.Then rating frequency analysis and Spearman correlation test were applied to analyze the correlation of measurement results.Results Overall,to the same patient,the correlation of D-dimer tested by Siemens Innovance D-DIMER Reagent with FDP level was significant positive(r= 0.954,P<0.01),better than that tested by Siemens DD Plus Reagent(r=0.885,P<0.01); and this correlation had an increasing trend when D-dimer level raised.When D-dimer level >5 mg/L FEU,the correlation was the best(P<0.01).And by calculating theamount of positive FDP(FDP>5 μg/ml)and FDP positive rate in both different cases when D-dimer results was also positive,FDP positive rate in Innovance D-DIMER Reagent group(about 65.76%)was lower than DD Plus Reagent group,it indicated that D-dimer results tested by Innovance D-DIMER Reagent could raise before FDP reacted,so D-dimer had a higher sensitivity than FDP.Conclusion It can provide a more precise clinical diagnosis and treatmentinformation when using Siemens Innovance D-DIMER Reagent to detect D-dimer values and combined FDP values at the same time.

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备注/Memo

备注/Memo:

作者简介:刘 莎(1989-),女,本科,检验技师,研究方向:血液学,Tel:15882204057,E-mail:535277496@qq.com。
通讯作者:江咏梅,女,硕士生导师,主任技师,Tel:13880516677,E-mail:serain33@163.com。
更新日期/Last Update: 2015-01-30