[1]林秀清,杨 新,江 艳,等.ApoB/ApoA-I比值在慢性乙型肝炎(重型)中的评估价值[J].现代检验医学杂志,2015,30(01):137-139.[doi:10.3969/j.issn.1671-7414.2015.01.041]
　LIN Xiu-qing,YANG-Xin,JIANG Yan,et al.ApoB/ApoA-I Ratio is a Potential Marker to Assess the Severity of Chronic Hepatitis B Virus Infection[J].Journal of Modern Laboratory Medicine,2015,30(01):137-139.[doi:10.3969/j.issn.1671-7414.2015.01.041]
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ApoB/ApoA-I比值在慢性乙型肝炎(重型)中的评估价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
137-139
栏目:
检验与临床
出版日期:
2015-01-30

文章信息/Info

Title:
ApoB/ApoA-I Ratio is a Potential Marker to Assess the Severity of Chronic Hepatitis B Virus Infection
文章编号:
1671-7414(2015)01-137-03
作者:
林秀清; 杨 新; 江 艳; 张宝华
南京军区福州总医院第二住院部检验科,福州 350003
Author(s):
LIN Xiu-qing; YANG-Xin; JIANG Yan; ZHANG Bao-hua
Clinical Laboratory,the Second Out-Patient Department, Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350003,China
关键词:
慢性乙型肝炎(重型);  脂类;  ApoB/ApoA-I比值
分类号:
R512.62; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.01.041
文献标志码:
A
摘要:
目的 分析并比较慢性乙型肝炎患者血清胆固醇(CHOL),三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A(ApoA-I)、载脂蛋白B(ApoB)等指标的检测结果,探讨ApoB/ApoA-I比值在慢性乙型肝炎(重型)中的评估价值。方法 统计2013年1～10月南京军区福州总医院收治的慢性乙型肝炎患者183例(包括慢性乙型肝炎轻型80例、中型46例和重型57例)、肝炎后肝硬化患者71例和正常对照59例,并对其CHOL,TG,HDL,LDL,ApoA-I和ApoB等检测结果进行分析。结果 与正常对照组相比,慢性乙型肝炎组和肝炎后肝硬化组的CHOL,TG,HDL,LDL,ApoA-I和ApoB等指标均有不同程度的降低。慢性乙型肝炎(重型)和肝炎后肝硬化组降幅更明显,与对照组比较,差异有统计学意义(P值<0.001)。除CHOL,LDL和ApoB外,慢性乙型肝炎轻型组及中型组与正常对照组比较,TG,HDL,ApoA-I等检测结果与正常对照组比较,差异具有统计学意义(P值<0.05)。慢性乙型肝炎(重型)的ApoB/ApoA-I比值为2.10±1.44,明显高于对照组、肝炎后肝硬化组以及慢性乙型肝炎的轻型和中型组,且分别与这4组比较,差异有统计学意义(P值均<0.05)。结论 ApoB/ApoA-I比值可以反映肝细胞的功能状态,可能作为判断慢性乙型肝炎(重型)的指标之一,为临床治疗和预后评估提供有力依据。
Abstract:
Objective To observe the change of the sera lipid profiles in patients with chronic hepatitis B Virus(HBV)infection.Methods Sera from 254 patients suffered from liver disease were collected and divided into four groups according to the severity of the disease(71 of Cirrhosis; 80,46,51 of Light,Moderate and Highly severity of the chronic HBV infection,respectively).Sera of 59 healthy patients were collected as control.The concentrations of their sera lipids(CHOL and TG),lipoprotein(HDL and LDL)and apolipoproteins(ApoA-I and ApoB)were determined and compared.Results Compared to the control group,the levels of the CHOL,TG,HDL,LDL,ApoA-I and ApoB were varied in degree in the chronic HBV infection group and the cirrhosis group.For the highly severity group and the cirrhosis group,statistics analysis showed decreased and significantly different lipid and apolipoprotein results when compared to the control group.For the light and moderate severity group,when compared to the control group,levels of TG,HDL and ApoA-I were decreased with remarkable difference.The ApoB/ApoA-I ratioof the chronic HBV infection(Highly severity group)was 2.10±1.44,which wassignificantly higher than that of any other group(P<0.05).Conclusion The ApoB/ApoA-I ratio can be a potential marker for the evaluation of the severity of the chronic HBV infection.

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备注/Memo

备注/Memo:

作者简介:林秀清(1980-),女,技师,长期从事临床生化检验工作。
通讯作者:张宝华,Tel:0591-38280361,传真:0591-38280361,E-mail:zhangbaohuajyk@163.com。
更新日期/Last Update: 2015-01-30