[1]李 礼,胡娟玉,于正清,等.血管生成素样蛋白1和2水平在胃癌患者中的表达及临床意义[J].现代检验医学杂志,2015,30(02):55-57.[doi:10.3969/j.issn.1671-7414.2015.02.017]
　LI Li,HU Juan-yu,YU Zheng-qing,et al.Expression and Clinical Significance of Angiopoietin Like Protein 1 and 2 in Patients with Gastric Cancer[J].Journal of Modern Laboratory Medicine,2015,30(02):55-57.[doi:10.3969/j.issn.1671-7414.2015.02.017]
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血管生成素样蛋白1和2水平在胃癌患者中的表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
55-57
栏目:
论著
出版日期:
2015-03-20

文章信息/Info

Title:
Expression and Clinical Significance of Angiopoietin Like Protein 1 and 2 in Patients with Gastric Cancer
作者:
李 礼1; 胡娟玉2; 于正清1; 钱 雷1
1.滨海县人民医院检验科,江苏滨海 224500; 2.滨海县第二人民医院检验科,江苏滨海 224541
Author(s):
LI Li1; HU Juan-yu2; YU Zheng-qing1; QIAN Lei1
1.Department of Clinical Laboratory, Binhai People's Hospital,Jiangsu Binhai 224500,China; 2. Department ofClinical Laboratory, the Second People's Hospital of Binhai,Jiangsu Binhai 224541,China
关键词:
血管生成素样蛋白1;  血管生成素样蛋白2;  胃癌
分类号:
R735.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2015.02.017
文献标志码:
A
摘要:
目的 探讨血管生成素样蛋白(Ang)1和2水平在胃癌患者中的表达以及临床应用价值。方法 收集2012年6月～2014年12月胃癌患者65例,选择同期健康体检者50例为对照组,采用酶联免疫吸附试验(ELISA法)检测研究对象中Ang-1和Ang-2水平,并与对照组作比较。结果 胃癌组中Ang-1水平(19.8±2.1 μg/L)和对照组(19.5±1.7 μg/L)间差异无统计学意义(P>0.05),Ang-2水平(2.3±0.8 μg/L)显著高于正常对照组(0.8±0.2 μg/L,t=2.50,P<0.01); 不同胃癌病理分型中Ang-2水平差异无统计学显著性意义(P>0.05)。Ⅲ～Ⅳ期患者的Ang-2水平(2.6±0.5 μg/L)显著高于Ⅰ～Ⅱ期(1.6±0.4 μg/L)患者,有淋巴结转移的患者Ang-2水平(2.7±0.5 μg/L)显著高于无淋巴结转移(1.6±0.5 μg/L)的患者,而且术后1年复发患者的Ang-2水平(2.0±0.6 μg/L)显著高于未复发患者(1.2±0.5 μg/L),经比较差异均有统计学意义(P均<0.05)。Ang-2水平和肿瘤的分期和淋巴结转移均呈正相关(r分别为0.31和0.33,P均<0.05)。结论 胃癌患者中Ang-2水平显著升高,与肿瘤分期、转移和预后相关,对胃癌病程进展、疗效观察和预后评估有重要的临床价值。
Abstract:
Objective To explore the expressions and clinical value of angiopoietin like protein 1(Ang-1)and angiopoietin like protein 2(Ang-2)in patients with gastric cancer.Methods 65 patients with gastric cancer and 50 healthy subjects for control group were collected from June in 2012 to December in 2014.The level of Ang-1 and Ang-2 were determined by enzyme-linked immunosorbent assay(ELISA).The results were compared.Results Compared with control group(19.8±2.1 μg/L),the level of Ang-1 in patients with gastric cancer(19.8±2.1 μg/L)was no statistics difference(P>0.05),but Ang-2(2.3±0.8 μg/L)was significantly higher than those of healthy subjects(0.8±0.2 μg/L,t=2.50,P<0.01).There was no significant difference of Ang-2 level in different pathological types of gastric cancer(P>0.05).The level of Ang-2 in TNM stage Ⅲ～Ⅳ(2.6±0.5 μg/L)was obviously higher than that in stage.Ⅰ～Ⅱ(1.6±0.4 μg/L).Ang-2 levels were significantly higher in patients with lymph nodemetastasis(2.7±0.5 μg/L)or postoperative recurrence after one year(2.0±0.6 μg/L)than those without lymph node metastasis(1.6±0.5 μg/L)or postoperative recurrence(1.2±0.5 μg/L,P<0.05).The level of Ang-2 in gastric cancer was significantly positive correlated with tumor stage and lymph node metastasis(r=0.31 and 0.33 respectively,P<0.01).Conclusion Ang-2 level was significantly increased in gastric cancer.Its level was significantly correlated with tumor stage,lymph node metastasis and prognosis,which has important application value for the cancer progression,clinical observation and prognosis evaluation of gastric cancer.

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备注/Memo

备注/Memo:
作者简介:李 礼(1977-),男,硕士,副主任检验师,主要从事临床生化检验诊断,E-mail:lili5898@126.com。
更新日期/Last Update: 2015-03-20