[1]高宏娥,李荫桂,黄海云,等.缺血性脑卒中患者血浆脂蛋白相关磷脂酶A2测定的临床意义[J].现代检验医学杂志,2015,30(02):58-60,64.[doi:10.3969/j.issn.1671-7414.2015.02.018]
　GAO Hong-e,LI Yin-gui,HUANG Hai-yun,et al.Clinical Significance of Plasma Lipoprotein-Associated Phospholipase A2 Detecting in Patients with Ischemic Cerebral Stroke[J].Journal of Modern Laboratory Medicine,2015,30(02):58-60,64.[doi:10.3969/j.issn.1671-7414.2015.02.018]
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缺血性脑卒中患者血浆脂蛋白相关磷脂酶A2测定的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
58-60,64
栏目:
论著
出版日期:
2015-03-20

文章信息/Info

Title:
Clinical Significance of Plasma Lipoprotein-Associated Phospholipase A2 Detecting in Patients with Ischemic Cerebral Stroke
作者:
高宏娥1; 李荫桂2; 黄海云1; 梁 伟1
1.十堰市东风花果医院检验科,湖北十堰 442000; 2.十堰市东风总医院检验部,湖北十堰 442000
Author(s):
GAO Hong-e1; LI Yin-gui2; HUANG Hai-yun1; LIANG Wei1
1.Department of Clinical Laboratory,Dongfeng Huaguo Hospital in Shiyan City, Hubei Shiyan 442000,China; 2.Department of Clinical Laboratory, Dongfeng General Hospital in Shiyan City,Hubei Shiyan 442000,China
关键词:
脑血管疾病;  缺血性脑卒中;  脂蛋白相关磷脂酶A2
分类号:
R743.3; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.02.018
文献标志码:
A
摘要:
目的 探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA2)测定在缺血性脑卒中(ICS)诊治中的价值。方法 选择2011年1月～2014年6月期间十堰市东风花果医院124例ICS患者(ICS组)、50例出血性脑卒中患者(出血组)作为研究对象,并选择同期体检者50例作为对照组,比较三组血浆Lp-PLA2水平,并比较有无颈动脉粥样硬化斑块、不同病情ICS患者血浆Lp-PLA2水平。结果 ICS组、出血组和对照组血浆Lp-PLA2水平分别为58.4±9.6 μg/L,30.5±9.2 μg/L和18.7±8.3 μg/L,组间差异有统计学意义(F=16.741,P=0.000); 血浆Lp-PLA2水平有斑块组高于无斑块组(66.3±9.7 μg/L vs 54.1±10.3 μg/L,t=5.775,P=0.000),不稳定型斑块组高于稳定型斑块组(72.4±9.5 μg/L vs 62.8±10.1 μg/L,t=4.797,P=0.000); 轻型、中型、重型ICS患者血浆Lp-PLA2水平分别为48.4±9.2 μg/L,60.9±9.6 μg/L和74.5±10.3 μg/L,三组间差异有统计学意义(F=13.629,P=0.000),血浆Lp-PLA2水平与ICS患者NIHSS评分呈正相关(r=0.716,P<0.05); Lp-PLA2诊断ICS ROC曲线下面积为0.904,最佳临界值为45.2 μg/L,敏感度、特异度分别为81.5%和80.2%。结论 血浆LP-PLA2检测对ICS具有良好的诊断效能,其血浆水平可反应ICS患者病情程度和动脉粥样硬化斑块的稳定性。
Abstract:
Objective To investigate the clinical significance of plasma lipoprotein-associated phospholipase A2(LP-PLA2)determination in patients with ischemic cerebral stroke(ICS).Methods 124 patients with ICS(ICS group)admitted to Dongfeng Huaguo Hospital in Shiyan City from Jan.2011 to June.2014 and 50 patients with hemorrhagic stroke(hemorrhagic group)were as the research objects,and 50 healthy controls at the same time were as the control group,compared the plasma Lp-PLA2 levels between the three groups,and compared carotid artery atherosclerotic plaque and plasma Lp-PLA2 levels in patients with different severity of ICS.Results The levels of plasma Lp-PLA2 of the patients of the ICS group,the hemorrhage group and the control group were 58.4±9.6 g/L,30.5±9.2 g/L and 18.7±8.3 g/L,respectively.There were significant differences between the groups(F=16.741,P=0.000).The level of plasma Lp-PLA2 of the patients of the plaque group was higher than that of the non-plaque group(66.3 ±9.7 g/L vs54.1±10.3 g/L,t=5.775,P=0.000),and the unstable plaque group was higher than that of the stable plate group(72.4±9.5 g/L vs 62.8±10.1 g/L,t=4.797,P=0.000).The plasma Lp-PLA2 level of patients with light,medium,heavy ICS were 48.4±9.2 g/L,60.9± 9.6 g/L and 74.5±10.3 g/L,respectively,and the difference was statistically significant between the three groups(F=13.629,P=0.000).The plasma levels of Lp-PLA2 were positively correlated with NIHSS scores in patients with ICS(r=0.716,P<0.05).Lp-PLA2 indiagnosis of ICS area under the ROC curve was 0.904,the optimal critical value was 45.2 μg/L,the sensitivity and specificity were 81.5% and 80.2%.Conclusion The determination of plasma LP-PLA2 has a good effect in diagnosis of ICS,the plasma level of ICS can be responsed the severity of the patients and the stability of atherosclerotic plaque.

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备注/Memo

备注/Memo:
作者简介:高宏娥(1972-),女,大专,主管技师,研究方向:临床检验、免疫,Tel:13593776638,E-mail:ghe729@163.com。
更新日期/Last Update: 2015-03-20