[1]李国春a,曹 娜a,王 忆b,等.基础血尿酸水平与糖负荷后胰岛素分泌相关性研究[J].现代检验医学杂志,2015,30(02):105-106,110.[doi:10.3969/j.issn.1671-7414.2015.02.032]
　LI Guo-chuna,CAO Naa,WANG Yib,et al.Relationship between Concentration of Fasting Uric Acid and Insulin Secretion after Glycemia Burden[J].Journal of Modern Laboratory Medicine,2015,30(02):105-106,110.[doi:10.3969/j.issn.1671-7414.2015.02.032]
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基础血尿酸水平与糖负荷后胰岛素分泌相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
105-106,110
栏目:
研究简报·实验技术
出版日期:
2015-03-20

文章信息/Info

Title:
Relationship between Concentration of Fasting Uric Acid and Insulin Secretion after Glycemia Burden
作者:
李国春a; 曹 娜a; 王 忆b; 巫开文a; 袁 辉a
南京市市级机关医院a.检验科; b.内分泌科,南京 210018
Author(s):
LI Guo-chuna; CAO Naa; WANG Yib; WU Kai-wena; YUAN-Huia
a.Department of Clinical Laboratory; b.Department of Endocrine,Nanjing Governmental Hospital,Nanjing 210018,China
关键词:
血尿酸;  胰岛素;  2型糖尿病
分类号:
R587.1; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.02.032
文献标志码:
A
摘要:
目的 研究不同血尿酸水平人群糖负荷后胰岛素分泌差异,分析胰岛素分泌和血尿酸(SUA)的关系。方法 对877例符合要求对象进行生化检查行OGTT试验。将研究对象分为尿酸正常组(NUA)和高尿酸组(HUA),比较两组糖负荷后胰岛素(INS)0,30,60,120和180 min(INS0,INS30,INS60,INS120,INS180)分泌差异。以血尿酸水平为因变量行多因素逐步回归分析,分析血尿酸水平影响因素。结果 HUA组男性女性0,30,60,120和180 min胰岛素分泌均高于NUA组(P均<0.05); 糖负荷后各时段INS分泌与SUA水平Pearson相关系数分别为0.107,0.154,0.195,0.157和0.112(P<0.01)。多因素逐步回归分析显示SUA的影响因素有女性,INS60,TC,HDL(β值-0.214,0.194,0.253和-0.119,P<0.01)。结论 糖负荷后的HUA组各时段INS分泌高于NUA组,INS分泌与SUA水平正相关; INS60,TC与SUA水平正相关,性别(女性)、HDL与SUA负相关。提示或可将空腹SUA作为INS(尤其是INS60)分泌潜在标志物运用于临床。
Abstract:
Objective To explore the relationship between fasting serum concentration of uric acid(SUA)and the secretion of insulin underoral glucose tolerance test(OGTT)in 877 eligible subjects.MethodsA 75g OGTT was administrated to all 877 eligible subjects,fastinguric acid,concentration of glucose and insulin of 0,30,60,120 and 180 min utes after OGTT were measured.Subjects were divided into high SUA group(HUA)andnormal SUA group(NUA)according the concentration of SUA.SPSS 13.0 were usedto analyze these data.Results Subjects in HUA had higher concentration of insulin in 0,30,60,120 and 180 min utes than NUA.There were positive correlation between SUA and INS in 0,30,60,120 and 180 min utes,Pearson r-value was 0.107,0.154,0.195,0.157 and 0.112(all P<0.01)respectively.By stepwise linear regression analyze,there were four parameters correlated with SUA:gender(female),INS60,cholesterol(TC),high density lipoprotein(HDL),β-vaule was -0.214,0.194,0.253,-0.119(all P<0.01)respectively.Conclusion SUA positive correlated with secretion of INS after glycemia burden,SUA may be used as a potential biomark ofsecretin of INS(especially the concentration of INS 60).

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:李国春(1981-),女,硕士研究生,主管技师,从事生化检验工作,研究方向:临床生化检验,Tel:15651858762,E-mail:njlgc@126.com。 通讯作者:巫开文(1965-),男,主任技师,从事生化检验工作,研究方向:临床生化检验。
更新日期/Last Update: 2015-03-20