[1]钟 堃,王 薇,何法霖,等.国内临床化学9项常规项目参考区间与即将发布的卫生行业标准的比较和分析[J].现代检验医学杂志,2015,30(03):38-42.[doi:10.3969/j.issn.1671-7414.2015.03.011]
　ZHONG Kun,WANG Wei,HE Fa-lin,et al.Comparison and Analysis of the Reference Intervals of 9 Serum Routine Chemical Analytes between the Current Application of Clinical Laboratories and the Latest Health Industrial Standards Draft for Approval[J].Journal of Modern Laboratory Medicine,2015,30(03):38-42.[doi:10.3969/j.issn.1671-7414.2015.03.011]
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国内临床化学9项常规项目参考区间与即将发布的卫生行业标准的比较和分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
38-42
栏目:
论著
出版日期:
2015-06-10

文章信息/Info

Title:
Comparison and Analysis of the Reference Intervals of 9 Serum Routine Chemical Analytes between the Current Application of Clinical Laboratories and the Latest Health Industrial Standards Draft for Approval
文章编号:
1671-7414(2015)03-038-05
作者:
钟 堃; 王 薇; 何法霖; 王治国
北京医院 卫生部临床检验中心,北京 100730
Author(s):
ZHONG Kun; WANG Wei; HE Fa-lin; WANG Zhi-guo
Beijing Hospital,National Center for Clinical Laboratories,Beijing 100730,China
关键词:
常规生化;  参考区间;  卫生行业标准
分类号:
R446
DOI:
10.3969/j.issn.1671-7414.2015.03.011
文献标志码:
A
摘要:
目的 对全国医院检验科常规化学检验项目的参考区间进行调查,并与即将发布的卫生行业标准进行比较。方法 采用基于Web方式的室间质量评价(EQA)软件系统,收集2012年度参加全国常规化学参考区间调查的实验室所上报的数据,使用专业统计软件对数据进行统计分析。结果 共385家实验室回报了调查结果。在即将发布的卫生行业标准所涉及的检验项目中,绝大多数项目不分组或未给出分组时所使用的参考区间与行业标准相比较都存在显著统计学差异[t=-55.435～17.070,P＜0.05,占86.1%(31/36)]。只有较少的实验室对参考区间进行了分组(约20%),部分实验室的分组规则与行业标准有一定的差异,与行业标准分组相同的实验室所给出的参考区间与行业标准相比也多存在极显著统计学差异[t=-39.365～13.155,P＜0.01,占62.5%(10/16)]。结论 即将发布参考区间与实际工作中所应用的参考区间差异较大,推广已经建立的具有权威性的临床常用生化检验项目参考区间很有必要在实际工作中使用行业标准所给出的参考区间前应进行参考区间的评估和验证。
Abstract:
Objective To investigate the current application status of reference intervals in routine chemistry and compare with the current health industry standards draft for approval.Methods By using web-based external quality assessment(EQA)software system,collectedthe submitted data from the laboratories which attended national reference intervals investigation,used professional statistical software to analyze the data.Results 385 laboratories had submitted the investigation results.The vast majority of the analytes of attended laboratories had significant statistical differences in comparison with the health industry standardsdraft for approval in no grouping and not filled groups[t=-55.435～17.070,P＜0.05,86.1%(31/36)].Only a few of laboratories' reference interval had been grouped(approximately 20%).There were some differences in grouping rules between laboratories and standards.Even though some of the laboratories adoptthe grouping rules as same as the standards,there were still big differencesin reference intervals between the laboratories and the standards[t=-39.365～13.155,P＜0.01, 62.5%(10/16)].Conclusion Thereference intervals of routine chemistry analytes suggested by the health industry standards draft for approval had quite big differences from the reference intervals used in current clinical laboratories daily work.It is important to propel the authority health industry standards to use in the daily work of clinicallaboratories.The evaluation and validation of using them should be done first.

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备注/Memo

备注/Memo:
作者简介:钟 堃(1984-),男,硕士,助理研究员,研究方向为临床实验室管理。
通信作者:王治国,研究员,E-mail:zgwang@nccl.org.cn。
更新日期/Last Update: 2015-06-10