[1]赵长胜,董 倩,张海涛,等.新诊断2型糖尿病患者GADA和ZnT8A自身抗体检测意义研究[J].现代检验医学杂志,2015,30(03):50-52.[doi:10.3969/j.issn.1671-7414.2015.03.014]
　ZHAO Chang-sheng,DONG Qian,ZHANG Hai-tao,et al.Role of Detecting GADA and ZnT8A in Newly Diagnosed Type 2 Diabetes Patients[J].Journal of Modern Laboratory Medicine,2015,30(03):50-52.[doi:10.3969/j.issn.1671-7414.2015.03.014]
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新诊断2型糖尿病患者GADA和ZnT8A自身抗体检测意义研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
50-52
栏目:
论著
出版日期:
2015-06-10

文章信息/Info

Title:
Role of Detecting GADA and ZnT8A in Newly Diagnosed Type 2 Diabetes Patients
文章编号:
1671-7414(2015)03-050-03
作者:
赵长胜1; 董 倩1; 张海涛1; 杨锡琴2; 赵 照3; 王国华2; 赵琰枫2; 张贺秋2; 冯晓燕2
1.唐山市丰南区钱营中心卫生院,河北唐山 063301;
2.军事医学科学院基础医学研究所,北京 100850;
3.首都师范大学数科院,北京100048
Author(s):
ZHAO Chang-sheng1; DONG Qian1; ZHANG Hai-tao1; YANG Xi-qin2;  ZHAO Zhao3; WANG Guo-hua2; ZHAO Yan-feng2; ZHANG He-qiu2; FENGXiao-yan2
1.Fengnan District Qianying Center Hospital,Hebei Tangshan 063301,China;
2.Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China;
3.Capital Normal University Mathematical Sciences,Beijing 100048,China
关键词:
新诊断2型糖尿病;  成人迟发型自身免疫性糖尿病;  谷氨酸脱羧酶自身抗体;  锌转运子8自身抗体
分类号:
R587.1; R392.11
DOI:
10.3969/j.issn.1671-7414.2015.03.014
文献标志码:
A
摘要:
目的 分析新诊断2型糖尿病患者中谷氨酸脱羧酶自身抗体(GADA)和锌转运子8自身抗体(ZnT8A)阳性情况。方法 通过ELISA法检测2014年5月～10月收集的101例新诊断2型糖尿病患者血清样本GADA和ZnT8A水平。结果 GADA阳性率为21.78%,ZnT8A阳性率为17.82%,两种自身抗体共同阳性率为8.91%,且GADA和ZnT8A阳性与否与患者的性别(t=-0.724,-0.550; 0.903,1.359,P值均＞0.05)、年龄(r=-0.185,-0.158; 0.367,0.084,P值均＞0.05)、血糖(r=0.290,0.110; -0.264,-0.047,P值均＞0.05)、胆固醇(r=-0.047,0.004; 0.154,-0.138,P值均＞0.05)、三酰甘油(r=-0.092,-0.054; -0.217,-0.023,P值均＞0.05),以及低密度脂蛋白(r=-0.045,-0.027; 0.202,-0.025,P值均＞0.05)水平不存在明显相关性。结论 为了早期诊断成人迟发型自身免疫性糖尿病患者,应该对新诊断的2型糖尿病患者及时进行自身抗体的筛查。
Abstract:
Objective To analysis the positive rates of glutamic acid decarboxylase autoantibody(GADA)and zinc transporter 8 autoantibody(ZnT8A)in newly diagnosed type 2 diabetes patients.Methods GADA and ZnT8A were detected in 101 cases of newly diagnosed type 2 diabetes mellitus patients using ELISA.Results The positive rate of GADA was 21.78%,the positive rate of ZnT8A was 17.82%,and the common positive rate of GADA and ZnT8A was 8.91%.There were no correlations between GADA or ZnT8A autoantibodies and the patient's sex(t=-0.724,-0.550; 0.903,1.359,P＞0.05),age(t=-0.724,-0.550; 0.903,1.359,P＞0.05),blood glucose(r=0.290,0.110; -0.264,-0.047,P＞0.05),cholesterol(r=-0.047,0.004; 0.154,-0.138,P＞0.05),triglyceride(r=-0.092,-0.054; -0.217,-0.023,P＞0.05),and low density lipoprotein(r=-0.045,-0.027; 0.202,-0.025,P＞0.05).Conclusion It should be screened autoantibodies timely for newly diagnosed type 2 diabetic patients in order to diagnosis the Latent autoimmune diabetes in adults early.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:十二五国家高技术研究发展计划(863计划)课题,编号2011AA02A113。
作者简介:赵长胜(1969-),男,大专,主治医师,从事全科医学,Tel: 15933424770,E-mail:531177954@qq.com。
通讯作者:冯晓燕(1973-),女,博士,副研究员,主要研究方向为疾病诊断标志物筛选与诊断试剂研制,Tel:13011821686,E-mail:xyfeng2002@126.com。
更新日期/Last Update: 2015-06-10