[1]李晓慧,黄海燕.尿微量蛋白和BNP联合诊断心肾综合征的意义[J].现代检验医学杂志,2015,30(03):136-138.[doi:10.3969/j.issn.1671-7414.2015.03.041]
　LI Xiao-hui,HUANG Hai-yan.Diagnostic Significance of Microalbuminuria Combined BNP for Cardiorenal Syndrome[J].Journal of Modern Laboratory Medicine,2015,30(03):136-138.[doi:10.3969/j.issn.1671-7414.2015.03.041]
点击复制

尿微量蛋白和BNP联合诊断心肾综合征的意义()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
136-138
栏目:
检验与临床
出版日期:
2015-06-10

文章信息/Info

Title:
Diagnostic Significance of Microalbuminuria Combined BNP for Cardiorenal Syndrome
文章编号:
1671-7414(2015)03-136-04
作者:
李晓慧1; 黄海燕2
1.北京市西城区展览路医院内科,北京 100044;
2.海南省人民医院急诊科,海口 570100
Author(s):
LI Xiao-hui1; HUANG Hai-yan2
1.Department of Internal Medicine, Exhibition Road Hospital of Xicheng District,Beijing 100044,China;
2.Emergency Department of Hainan Provincial People's Hospital,Haikou 570100,China
关键词:
尿微量蛋白;  脑钠肽;  心肾综合征;  诊断
分类号:
R692; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.03.041
文献标志码:
A
摘要:
目的 探讨尿微量蛋白和脑钠肽(BNP)联合诊断心肾综合征的意义。方法 2011年8月～2014年2月选择在北京市西城区展览路医院住院诊治的心肾综合征患者45例作为观察组,选择同期在该院进行体检的健康人45例作为对照组,两组都进行了超声检查与尿液、血液学指标检测,同时对临床资料进行调查。结果 观察组的主动脉根部内径、左房内径和室间隔厚度都明显高于对照组(P＜0.05),而两组的右室内径与左心室射血分数对比差异无统计学意义。观察组的尿素氮、肌酐、脑钠肽与尿微量蛋白含量都明显高于对照组(P＜0.05)。logistic多元回归分析显示导致心肾综合征发生的主要独立危险因素包括脑钠肽、尿微量蛋白、主动脉根部内径与尿素氮等(P＜0.05)。结论 尿微量蛋白和BNP联合诊断心肾综合征有很好的诊断价值,能有效判断疾病状况,也是心肾综合征发生的独立危险因素。
Abstract:
Objective To investigate the diagnostic significance of microalbuminuria combined BNP for cardiorenal syndrome.Methods Selected 45 patients with cardiorenal syndrome from August 2011to February 2014 in the Exhibition Road,Xicheng District hospital in Beijingas the observation group,choose the 45 cases of healthy people at same period in the Exhibition Road,Xicheng District hospital in Beijing as the control group,two groups were carried out ultrasound and urine,hematological tested,whilethe clinical data were investigated.Results The aortic root diameter,left atrial diameter and septal thickness of the observation groupwere significantly higher(P＜0.05),while the right ventricular diameter and left ventricular ejection fraction compared in the two groups were no significant difference.The urea nitrogen,creatinine,brain natriuretic peptide and microalbuminuria contents in the observation group were significantly higher(P＜0.05).Multivariate logistic regression analysis showed that the main independent risk factors for cardiorenal syndrome included brain natriuretic peptide,microalbuminuria,aortic root diameter and blood urea nitrogen(P＜0.05).Conclusion The diagnosis of microalbuminuria combined BNP for cardiorenal syndrome has better diagnostic value that can effectively determine the disease status,and there were independent risk factors for cardiorenal syndrome.

参考文献/References:

[1] 钟 诚,何 浪,孙国建,等.肾动脉消融改善心脏再同步化治疗无效的扩张型心肌病患者慢性心力衰竭的临床研究[J].浙江医学,2014,12(11):1046-1048.
Zhong C,He L,Sun GJ,et al.Renal sympathetic nerve ablation in treatment of chronic heart failure for patients with dilated cardiomyopathy non-responding to car-diac resynchronization therapy[J].Zhejiang Medicine,2014,12(11):1046-1048.
[2] Hanada S,Takewa Y,Mizuno T,et al.Effect of the technique for assisting renal blood circulation on ischemic kidney in acute cardiorenal syndrome[J].J Artif Organs,2012,15(2):140-145.
[3] 贾冬音,张菲斐,韩战营,等.短期高渗盐水合并大剂量呋塞米对急性失代偿性心力衰竭患者的肾功能、NT-proBNP的影响[J].中国实用医刊,2014,41(9):92-94.
Jia DY,Zhang FF,Han ZY,et al.Effects of short-term hypertonic saline combined with high dose of furosemide in patients with acute decompensated heart failure of renal function and NT-proBNP[J].Chinese Journal of Practical Medicine,2014,41(9):92-94.
[4] 刘振玉.急性冠状动脉综合征患者血中嗜铬粒蛋白A、脑尿钠肽、去甲肾上腺素水平变化临床观察[J].中国实用医刊,2014,41(7):118-119.
Liu ZY.Acute coronary syndromes of blood in patients with syndromeof chromogranin A,brain natriuretic peptide,changes in noradrenaline level ofclinical observation[J].Chinese Journal of Practical Medicine,2014,41(7):118-119.
[5] Lassus JP,Harjola VP,Peuhkurinen K,et al.Cystatin C,NT-proBNP and inflammatory markers in acute heart failure insights into the cardiorenal syndrome[J].Biomarkers,2011,16(4):302-310.
[6] 杜 琳,张 晓,朱记法,等.不同他汀对急性冠脉综合征介入治疗术后早期肾功能的影响[J].中国实用医刊,2014,41(7):35-38.
Du L,Zhang X,Zhu JF,et al.Effects of different statins on the renal function of acute coronary syndrome after intervention[J].Chinese Journalof Practical Medicine,2014,41(7):35-38.
[7] Bosselmann H,Tonder N,Solétormos G,et al.Influence of renal impairment on myocardial function in outpatients with systolic heart failure:an echocardiographic and cardiac biomarker study[J].Int J Cardiol,2014,177(3):942-948.
[8] 高海军,张建伟.心肾相交理论对治疗慢性肾心综合征作用的研究[J].中医临床研究,2014,6(29):50-51.
Gao HJ,Zhang JW.An effective research on treating CRS through thexinshen xiangjiao theory[J].Clinical Journal Chinese Medicine,2014,6(29):50-51.
[9] Hanna EB,Hanna Deschamps E.Acute heart failure:acute cardiorenal syndrome and role of aggressive decongestion[J].Clin Cardiol,2014,37(12):773-778.
[10] 杨 硕,怀 伟,刘桂花,等.高敏心肌肌钙蛋白T在急性心肌梗死早期诊断中的临床价值[J].中华检验医学杂志,2014,37(2):150-154.
Yang S,Huai W,Liu GH,et al.Clinical value of high sensitivity cardiactroponin T in the diagnosis of acute myocardial infarction[J].Chinese Journalof Laboratory Medicine,2014,37(2):150-154.
[11] Palazzuoli A,Geyer A,Malandrino A,et al.Current therapeutic strategies in cardiorenal syndrome[J].Minerva Cardioangiol,2012,94(14):375-383.
[12] 张 炜,黄 洁,许海燕,等.心肺运动试验在扩张型心肌病慢性左心衰竭患者心功能评价中的应用价值[J].中华医学杂志,2014,94(14):1076-1079.
Zhang W,Huang J,Xu HY,et al.Value of cardiopulmonary exercise test incardiac function evaluation of patients with chronic left heart failure caused by dilated cardiomyopathy[J].Natl Med J China,2014,94(14):1076-1079.
[13] 吴 明,冯永文,李明利,等.血清半胱氨酸蛋白酶抑制剂C水平对于老年脓毒症患者急性肾损伤的价值探讨[J].中华危重症医学杂志(电子版),2014,7(5):14-18.
Wu M,Feng YW,Li ML,et al.Clinical value of cystein C in the aged patients with sepsis and acute kidney injury[J].Chinese Journal Critical Care Medicine(Electronic Edition),2014,7(5):14-18.
[14] Taub PR,Borden KC,Fard A,et al.Role of bi-omarkers in the diagnosisand prognosis of acute kidney injury in patients with cardiorenal syndrome[J].Expert Rev Cardiovasc Ther,2012,10(5):657-667.
[15] 梁献慧,王 沛,殷瑶瑶,等.N端脑钠肽前体在维持性血液透析患者非显性水肿容量负荷评估中的意义[J].中华肾脏病杂志,2014,30(9):660-664.
Liang XH,Wang P,Yin YY,et al.Assessment of the N-terminal pro-brainnatriuretic peptide in volume status in maintenance hemodialysis patients with non dominant edema[J].Chinese Journal of Nephrology,2014,30(9):660-664.
[16] 卢 鑫,胡桃红,谢晓春,等.重组人脑钠肽治疗急性心力衰竭合并肾功能不全的近期疗效观察[J].中国医药,2014,9(8):1105-1107.
Lu X,Hu TH,Xie XC,et al.Efficacy of recombinant human brain natriuretic peptide on acute heart failure with renal function insufficiency[J].ChineseMedicine,2014,9(8):1105-1107.
[17] Malbrain ML,Roberts DJ,Sugrue M,et al.The po-lycompartment syndrome:a concise state-of-the-art review[J].Anaesthesiol Intensive Ther,2014,46(5):433-450.
[18] 沈 波,聂宇昕,刘中华,等.维持性血液透析患者血浆氨基端脑钠肽前体水平及相关分析[J].中华肾脏病杂志,2014,30(8):586-591.
Shen B,Nie YX,Liu ZH,et al.Correlation analysis of N-terminal pro-brain natriuretic peptide in maintenance hemodialysis patients[J].Chinese Journal of Nephrology,2014,30(8):586-591.

相似文献/References:

[1]汪隆海a,陈启松b,夏 芳a,等.和肽素与大内皮素-1及N末端 脑钠肽对心力衰竭的预后价值[J].现代检验医学杂志,2015,30(01):64.[doi:10.3969/j.issn.1671-7414.2015.01.017]
　WANG Long-haia,CHEN Qi-songb,XIA Fanga,et al.Prognostic Value of Copeptin,Big Endothelin-1 and N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(03):64.[doi:10.3969/j.issn.1671-7414.2015.01.017]
[2]滑 艳,王海疆.尿液NT-proBNP水平在慢性心力衰竭诊断中的意义[J].现代检验医学杂志,2015,30(02):134.[doi:10.3969/j.issn.1671-7414.2015.02.042]
　HUA Yan,WANG Hai-jiang.Significance of Urinary NT-proBNP Levels for Diagnosis of Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(03):134.[doi:10.3969/j.issn.1671-7414.2015.02.042]

备注/Memo

备注/Memo:
基金项目:海南省卫生厅医学科研课题:基于Utstein模式下心源性心脏骤停心肺复苏的单因素研究,编号:琼卫2012 PT-21。
作者简介:李晓慧(1981-),女,硕士,主治医师,研究方向:老年医学和神经内科,Tel:18910083258,010-84998653,E-mail:lixh7683@163.com。
更新日期/Last Update: 2015-06-10