[1]郑福利,党 淼,张淼芳,等.子宫内膜癌组织中趋化因子CXCL12及其受体CXCR4表达水平研究[J].现代检验医学杂志,2015,30(04):21-23.[doi:10.3969/j.issn.1671-7414.2015.04.005]
　ZHENG Fu-li,DANG Miao,ZHANG Miao-fang,et al.Expression of Chemokine CXCL12 and Its Receptor CXCR4 in Endometrial Carcinoma Tissues[J].Journal of Modern Laboratory Medicine,2015,30(04):21-23.[doi:10.3969/j.issn.1671-7414.2015.04.005]
点击复制

子宫内膜癌组织中趋化因子CXCL12及其受体CXCR4表达水平研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年04期
页码:
21-23
栏目:
论著
出版日期:
2015-08-10

文章信息/Info

Title:
Expression of Chemokine CXCL12 and Its Receptor CXCR4 in Endometrial Carcinoma Tissues
文章编号:
1671-7414(2015)04-021-04
作者:
郑福利1; 党 淼1; 张淼芳1; 王 建2
1.陕西中医药大学第二附属医院妇产科, 陕西咸阳 712000;
2.第四军医大学西京医院妇产科,西安 710032
Author(s):
ZHENG Fu-li1; DANG Miao1; ZHANG Miao-fang1; WANG Jian2
1.Department of Obstetrics and Gynecology,the Second Affiliated Hospital,Shaanxi University of Chinese Medcine,Shaanxi Xianyang 721000,China;
2.Department of Obstetrics and Gynecology, Xijing Hospital,the Fourth Military Medical University,Xi'an 710
关键词:
子宫内膜肿瘤;  趋化因子CXCL12;  CXCR4
分类号:
R737.33; R730.43
DOI:
10.3969/j.issn.1671-7414.2015.04.005
文献标志码:
A
摘要:
目的 观察子宫内膜癌组织中趋化因子CXCL12及其受体CXCR4表达水平,探讨其与子宫内膜癌患者临床病理特征相关性。方法 收集2012年1月～2014年12月间入院接受手术的子宫内膜癌患者52例病理标本,年龄55.6±19.2岁,以正常子宫内膜26例为对照组,年龄52.3±16.5岁。采用免疫组化技术检测趋化因子CXCL12及其受体CXCR4在子宫内膜癌组织中的表达情况,并分析它们与FIGO分期、细胞分化程度、淋巴结转移和病理类型等临床病理特征的关系。结果 CXCL12和CXCR4在子宫内膜癌组织中阳性表达率分别为76.92%和69.23%,而在正常子宫内膜组织中则分别为34.62%和30.77%,差异具有统计学意义(χ2=11.826,P＜0.01)。CXCR4的表达与子宫内膜癌细胞分化程度存在差异,有统计学意义(均P＜0.05),且与分化高低呈正相关(r=0.386,P＜0.05)。在子宫内膜癌组织中,除CXCR4表达与细胞分化程度呈正相关外,CXCL12和CXCR4表达与临床分期、淋巴结转移和病理类型无相关性(P＞0.05)。结论 CXCL12和CXCR4在子宫内膜癌组织中表达明显升高,这可能在子宫内膜癌发生发展过程中发挥重要生物学作用。
Abstract:
Objective To observe the translations of chemokine CXCL12 and its receptor CXCR4 in endometrial carcinoma tissues,and to evaluate their significance in clinical pathologic features of endometrial carcinoma.Methods From Jan.2012 to Dec.2014,52 tissue specimens of patients with endometrial carcinoma were admitted to the hospital,aged 55.6±19.2 years,and 26 cases of normal endometrium as control,aged 52.3±16.5 years old.Expressions of CXCL12 and CXCR4 in the tissue specimens were detected by immunohistochemistry,and to analyze the relationship between the expressions and clinical pathological features,and FIGO stage,cell differentiation,lymph node metastasis and pathological type in endometrial carcinoma.Results In endometrial carcinoma,the positivity rates of CXCR4 and CXCL12 were 76.92% and 69.23% respectively.The positive expression rates ofwhich were 34.62% and 30.77% in normal endometrium tissues,statistically significant(χ2=11.826,P＜0.01).The expression of CXCR4 was positively correlated with the differentiation of endometrial carcinoma cells (P＜0.05).In endometrial carcinoma,with the exception of CXCR4 expression and cell differentiation was positively related(r=0.386,P＜0.05),CXCL12 and CXCR4 expression and clinical stage,pathological type and lymph node metastasis no correlation was found(P＞0.05).Conclusion The results showed that the expression of CXCL12 and CXCR4 in endometrial carcinoma tissues wassignificantly increased,which may play an important role in the development ofendometrial cancer.

参考文献/References:

[1] Jenabi E,Poorolajal J.The effect of body mass index on endometrial cancer: a meta-analysis[J].Public Health,2015:[Epub anead of print].
[2] Esposito K,Chiodini P,Colao A,et al.Metabolic syndrome and risk of cancer:a systematic review and meta-analysis[J].Diabetes Care,2012,35(11):2402-2411.
[3] Suh DH,Lee KH,Kim K,et al.Major clinical research advances in gynecologic cancer in 2014[J].J Gynecol Oncol,2015,26(2):156-167.
[4] Maroni P,Bendinelli P,Matteucci E,et al.HGF induces CXCR4 and CXCL12- mediated tumor invasion through Etsl and NF-kappa B[J].Carcinogenesis,2007,28(2):267-279.
[5] Muller A,Homey B,Soto H,et al.Involvement of chemokine receptors in breast cancer metastasis[J].Nature,2001,410(6824):50-56.
[6] Kitaya K,Nakayama T,Daikoku N,et al.Spatial and temporal expression of ligands for CXCR3 and CXCR4 in human endometrium[J].J Clin Endocrinol,2004,89(5):2470-2476.
[7] Dominguez F,Galan A,Martin JJ,et al.Hormonal and embryonic regulationof chemokin receptors CXCR1,CXCR4,CCR5 and CCR2B in the human endometrium and the human blastocyst[J].Mol Hum Reprod,2003,9(4):189-198.
[8] Mizokami Y,Kajiyama H,Shibata K,et al.Stromal cell-derived factor-1alpha induced cell proliferation and its possible regulation by CD26/dipeptidylpeptidase IV in endometrial adenocarcinoma[J].Int J Cancer,2004,110(5):652-659.
[9] Kryczek I,Wei S,Keller E,et al.Stroma-derived factor(SDF-1/CXCL12)and human tumor pathogenesis[J].Am J Physiol Cell Physiol,2007,292(3):C987-C995.
[10] Sakane R,Tsubamoto H,Sakata K,et al.Expression of chemokineligand 18 in stage IA low-grade endometrial cancer[J].Anticancer Res,2014,34(10):5331-5336.
[11] Walentowicz-Sadlecka M,Sadlecki P,Bodnar M,et al.Stromal derived factor-1(SDF-1)and its receptors CXCR4 and CXCR7 in endometrial cancer patients[J].PLoS One,2014,9(1):e84629.
[12] Giannice R,Erreni M,Allavena P,et al.Chemokines mRNA expression in relation to the macrophage migration inhibitory factor(MIF)mRNA and vascular endothelial growth factor(VEGF)mRNA expression in the microenvironment of endometrial cancer tissue and normal endometrium:a pilot study[J].Cytokine,2013,64(2):509-515.
[13] Felix AS, Stone RA, Chivukula M,et al.Survival outcomes in endometrial cancer patients are associated with CXCL12 and estrogen receptor expression[J].Int J Cancer,2012,131(2):E114-E121.
[14] Cacina C,Bulgurcuoglu-Kuran S,Iyibozkurt AC,et al.Genetic variantsof SDF-1 and CXCR4 genes in endometrial carcinoma[J].Mol Biol Rep,2012,39(2):1225-1229.
[15] Gelmini S,Mangoni M,Castiglione F,et al.The CXCR4/CXCL12 axis in endometrial cancer[J].Clin Exp Metastasis,2009,26(3):261-268.
[16] Laguri C, Arenzana-Seisdedos F, Lortat-Jacob H.Relationships between glycosaminoglycan and receptor binding sites in chemokines the CXCL12 example[J].Carbohydr Res,2008,343(12):2018-2023.
[17] Hartmann TN,Grabovsky V,Pasvolsky R,et al.A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activationbut not in chemokine-triggered motility of human T lymphocytes and CD34+ cells[J].J Leukoc Biol,2008,84(4):1130-1140.
[18] Faria SC,Sagebiel T,Balachandran A,et al.Imaging in endometrial carcinoma[J].Indian J Radiol Imaging,2015,25(2):137-147.
[19] Stoyanov S,Ananiev J,Ivanova K,et al.Molecular based targets and endometrial cancer[J].Akush Ginekol(Sofiia),2015,54(2):38-45.
[20] Esposito K,Chiodini P,Capuano A,et al.Metabolic syndrome and endometrial cancer:a meta-analysis[J].Endocrine,2014,45(1):28-36.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(No.81172458)。
作者简介:郑福利(1978-),女,主治医师,硕士,主要从事妇产科临床,Tel:18049414376,E-mail:zheng.337700@163.com。
通讯作者:王 建(1962-),男,主任医师,教授,主要从事妇产科临床与基础研究,E-mail:184183102@qq.com。
更新日期/Last Update: 2015-08-10