[1]白利芬,李 慧,王兴宁.联合检测PA,TBA与肝穿刺活检在慢性肝炎中的临床价值[J].现代检验医学杂志,2015,30(04):50-52.[doi:10.3969/j.issn.1671-7414.2015.04.013]
　BAI Li-fen,LI Hui,WANG Xing-ning.Clinical Value of Combined Detection of Prealbumin Total Bile Acid and Liver Biopsy in Chronic Hepatitis[J].Journal of Modern Laboratory Medicine,2015,30(04):50-52.[doi:10.3969/j.issn.1671-7414.2015.04.013]
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联合检测PA,TBA与肝穿刺活检在慢性肝炎中的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年04期
页码:
50-52
栏目:
论著
出版日期:
2015-08-10

文章信息/Info

Title:
Clinical Value of Combined Detection of Prealbumin Total Bile Acid and Liver Biopsy in Chronic Hepatitis
文章编号:
1671-7414(2015)04-050-03
作者:
白利芬; 李 慧; 王兴宁
延安大学医学院附属医院检验科,陕西延安 716000
Author(s):
BAI Li-fen; LI Hui; WANG Xing-ning
Department of Clinical Laboratory, Affiliated Hospital of Yan'an University Medical College,Shaanxi Yan'an716000,China
关键词:
慢性肝炎;  前清蛋白;  总胆汁酸;  肝穿刺活检
分类号:
R512.6; R446.1
DOI:
10.3969/j.issn.1671-7414.2015.04.013
文献标志码:
A
摘要:
目的 探讨联合检测前清蛋白(prealbumin,PA)、总胆汁酸(total bile acid,TBA)与肝穿刺活检,在慢性肝炎中的临床价值。方法 收集延安大学附属医院2013年10月～2014年3月期间的慢性肝炎住院患者172例为慢性肝炎组,同期正常健康体检者45例为对照组。两组分别行PA和TBA检测,PA采用免疫比浊法,TBA采用循环酶法,慢性肝炎组同时行经皮穿刺肝组织学检测。结果 慢性肝炎组PA值(179.12±8.46 mg/L)低于对照组(257.34±6.38 mg/L),差异具有统计学意义(P＜0.05); 慢性肝炎组TBA值(30.58±9.37 μmol/L)高于对照组(8.16±1.59 μmol/L),差异具有统计学意义(P＜0.05); PA含量与病理分级呈负相关(rs=-0.617,P＜0.05),TBA含量与病理分级呈正相关(rs=0.724,P＜0.05); PA单独检测诊断阳性率为58.7%(101/172),TBA单独检测诊断阳性率为80.2%(138/172)。两者联合检测诊断阳性率为93.6%(161/172),高于单独测定,差异具有统计学意义(P＜0.05)。结论 血清PA和TBA水平测定除能反映肝功能减退及肝内炎症程度以外,二者联合检测更能提高慢性肝炎诊断的阳性率,与组织学检测相比具有方便、简单、易操作的优点。
Abstract:
Objective To investigate the clinical value ofcombined test of prealbumin(PA),total bile acid(TBA)and liver biopsy in chronic hepatitis.Methods 172 patients hospitalized with chronic hepatitis in the Affiliated Hospital of Yan'an University Medical College from October,2013 to March,2014 was collected as the chronic hepatitis group; and 45 cases of normal healthy control of the corresponding period was collectedas the control group.Prealbumin,TBA was detected respectively in the two groups.Immunoturbidimetry was adopted in PA,Enzymatic cycling assay was employed inTBA,and at the same time percutaneous puncture of liver histology was detectedin the chronic hepatitis group.Results The PA in the chronic hepatitis group(179.12±8.46 mg/L)was lower than the control group(257.34±6.38 mg/L),and the difference was statistically significant(P＜0.05).The TBA in the chronic hepatitis group(30.58±9.37 μmol/L)was higher than the control group(8.16±1.59 μmol/L)and also the difference was statistically significant(P＜0.05).PA was negatively correlated with the pathological grades(rs=-0.617,P＜0.05),and TBA was positively correlated with pathological grades(rs=0.724,P＜0.05).The separate diagnostic positiverate of PA was 58.7%(101/172),while the TBA was 93.6%(161/172).The combined diagnostic positive rate of the two was 93.6%(161/172),it was higher than the separate rate and was statistically significant(P＜0.05).Conclusion The serum levels of PA and TBA can reflect the extent and degree of hypohepatia and hepatic inflammation,and the combined detection of thetwo will be much sensitive to the diagnosis of chronic hepatitis,and compared with histological detection,it is convenient,simple,and easy to operate.

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备注/Memo

备注/Memo:
作者简介:白利芬(1972-),女,本科,主管检验师,主要从事职业病与临床生化检验诊断,Tel:0911-2811299。
通讯作者:李 慧,E-mail:lihui334420@qq.com。
更新日期/Last Update: 2015-08-10