[1]李玉美,叶宁华,罗勇强,等.肺结核并发糖尿病患者外周血白细胞介素-22含量检测[J].现代检验医学杂志,2015,30(04):155-157.[doi:10.3969/j.issn.1671-7414.2015.04.048]
　LI Yu-mei,YE Ning-hua,LUO Yong-qiang,et al.Expression and Clinical Significance of Serum IL-22 on Patients with Pulmonary Tuberculosis and Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2015,30(04):155-157.[doi:10.3969/j.issn.1671-7414.2015.04.048]
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肺结核并发糖尿病患者外周血白细胞介素-22含量检测()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年04期
页码:
155-157
栏目:
检验与临床
出版日期:
2015-08-10

文章信息/Info

Title:
Expression and Clinical Significance of Serum IL-22 on Patients with Pulmonary Tuberculosis and Diabetes Mellitus
文章编号:
1671-7414(2015)04-155-03
作者:
李玉美1; 叶宁华2; 罗勇强1; 林东子1; 曾今诚3
1.东莞市第六人民医院,广东东莞 523008;
2.东莞市中医院,广东东莞 523000;
3.广东医学院广东省医学分子诊断重点实验室,广东东莞 523808
Author(s):
LI Yu-mei1; YE Ning-hua2; LUO Yong-qiang1; LINDong-zi1; ZENG Jin-cheng3
1.the Sixth People's Hospital of Dongguan City,Guangdong Dongguan 523008,China;
2.Dongguan Hospital of Traditional Chinese Medicine,Guangdong Dongguan 523000,China;
3.Guangdong Provincial Key Laboratory of Medical MolecularDiagnostics, Guangdo
关键词:
肺结核;  糖尿病;  白细胞介素-22
分类号:
R521; R587.1; R392.11
DOI:
10.3969/j.issn.1671-7414.2015.04.048
文献标志码:
A
摘要:
目的 检测肺结核并发糖尿病(PPTDM)患者外周血血清IL-22含量并分析其意义。方法 ELISA检测30例PPTDM患者、30例肺结核(PTB)患者、30例糖尿病(DM)患者和30例健康志愿者(HV)血清IL-22含量并分析其意义。结果 PPTDM组血清IL-22含量(54.4±4.81 pg/ml)显著低于DM组(72.36±5.12 pg/ml)和HV组(68.32±3.08 pg/ml),差异均有统计学意义(t=2.557,P=0.013; t=2.437,P=0.018)。PPTDM组血清IL-22含量高于PTB组(45.36±5.88 pg/ml),但差异无统计学意义(t=1.190,P=0.239)。不同形式肺结核并发糖尿病患者血清IL-22含量检测结果中,先患肺结核后患糖尿病(PTB-DM)组血清IL-22含量(64.62±8.59 pg/ml)显著高于先患糖尿病后患肺结核(DM-PTB)组(44.21±2.68 pg/ml),差异有统计学意义(t=2.267,P=0.031)。结论 IL-22在PPTDM疾病发生中可能具有重要作用。
Abstract:
Objective To study serum IL-22 levels in patients with pulmonary tuberculosis and diabetes mellitus(PPTDM)and to analysis their clinical significance.Methods ELISA was used to detect serum IL-22 levels in 30 cases PPTDM patients,30 cases pulmonary tuberculosis(PTB)patients,30 cases diabetes mellitus(DM)patients and 30 cases healthyvolunteers(HV).Results Serum IL-22 levels of PPTDM patients(54.4±4.81 pg/ml)were significantly lower than those in diabetes mellitus(DM)patients(72.36±5.12 pg/ml)and healthy volunteers(HV)(68.32±3.08 pg/ml)(t=2.557,P=0.013; t=2.437,P=0.018),respectively.There was no significantly different of serum IL-22 levels between PPTDM and PTB patients(t=1.190,P=0.239).Serum IL-22 levels of diabetes mellitus coincidentwith pulmonary tuberculosis(DM-PTB)patients(64.62±8.59 pg/ml)were significantly higher than those in pulmonary tuberculosis coincident with diabetes mellitus(PTB-DM)patients(44.21±2.68 pg/ml)(t=2.267,P=0.031).Conclusion IL-22 may play an important role in PPTDM development.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:广东省医学科研基金资助项目(B2013427),东莞市科技计划项目(201450715200503)。
作者简介:李玉美(1976-),女,本科,主管检验师,研究方向:结核病的分子生物学诊断,E-mail:liyumei@163.com。
通讯作者:曾今诚,研究方向:结核免疫,E-mail:zengjincheng83@126.com。
更新日期/Last Update: 2015-08-10