[1]吴子安,谢清娇,徐宁,等.醛固酮肾素定量比值筛查原发性醛固酮增多症的探讨[J].现代检验医学杂志,2015,30(05):8-11.[doi:10.3969/j.issn.1671-7414.2015.05.004]
　WU Zi-an,XIE Qing-jiao,XU Ning,et al.Investigating the Effectiveness of the Aldosterone to Active Renin Ratio (AARR) for Screening Primary Aldosteronism[J].Journal of Modern Laboratory Medicine,2015,30(05):8-11.[doi:10.3969/j.issn.1671-7414.2015.05.004]
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醛固酮肾素定量比值筛查原发性醛固酮增多症的探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
8-11
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Investigating the Effectiveness of the Aldosterone to Active Renin Ratio (AARR) for Screening Primary Aldosteronism
作者:
吴子安1; 谢清娇2; 徐宁1; 谭志容3; 尹芳芳3
1.广东省中医院芳村医院检验科，广州510370； 2.广州医学院医学检验系，广州510180；3.广州中医药大学，广州510405
Author(s):
WU Zi-an1; XIE Qing-jiao2; XU Ning1; TAN Zhi-rong3; YIN Fang-fang3
Department of Clinical Laboratory，Fangcun Hospital，Traditional Chinese Medicine Hospital，Guangzhou 510370，China； 2.Department of Medical Laboratory，Guangdong Medical College，Guangzhou 510180，China； 3.Traditional Chinese Medicine University of Guangzhou，Guangzhou 510405，China
关键词:
原发性醛固酮增多症; 醛固酮; 肾素定量; 醛固酮肾素定量比值
分类号:
R586.24；R446.1
DOI:
10.3969/j.issn.1671-7414.2015.05.004
文献标志码:
A
摘要:
目的探讨醛固酮肾素定量比值(PAC/PRC以下简称AARR)筛查原发性醛固酮增多症(以下简称为原醛症)的价值。方法使用化学发光方法检测32例原醛症和88例原发性高血压患者立、卧位醛固酮和肾素浓度，计算醛固酮肾素浓度比值(AARR)，构建AARR对原醛症的ROC曲线，确定AARR筛查原醛症的最佳切点。结果原醛症患者组立位肾素浓度为4.55(15.67)pg/ml，卧位为2.85(5.34)pg/ml，立位醛固酮浓度为213.70(237.38)pg/ml，卧位为207.52(137.90)pg/ml， 立位AARR为61.53(182.84)，卧位为100.69(254.03)。原发性高血压患者组立位肾素浓度为6.80(11.90)pg/ml，卧位为4.79(8.36)pg/ml，立位醛固酮浓度为121.20(31.94)pg/ml，卧位为112.47(23.99)pg/ml，立位AARR为17.49(28.57)，卧位为22.67(37.43)。立位AARR筛查原醛症的ROC曲线AUC为0.802，Youden’s指数提示最佳切点为54.40 pg/ml，灵敏度为0.719，特异度为0.852；卧位AARR筛查原醛症的ROC曲线AUC为0.848，最佳切点为64.18 pg/ml，灵敏度为0.750，特异度为0.818。卡方检验提示立、卧位AARR筛查原醛症的诊断效果差异无统计学意义(P>0.05)。结论临床上采用醛固酮肾素定量比值对原发性醛固酮增多症进行筛查有一定的应用价值，且立、卧位AARR诊断效果相当。
Abstract:
ObjectiveTo investigate the effectiveness of the aldosterone to active renin ratio(AARR) for screening primary aldosteronism(PA)．MethodsDetected the plasma renin concentration (PRC) and plasma aldosterone concentration of PA group (32 samples) and primary hypertension group(88 samples)．Used SPSS statistical software to analys the results of the patient and build the ROC of AARR for screening PA．ResultsThe PRC，PAC and AARR of the standing position of PA group was 4.55(15.67)pg/ml，213.70(237.38)pg/ml and 61.53(182.84)，whose recubent position results was 2.85(5.34)pg/ml，207.52(137.90)pg/ml and 100.69(254.03)at the same time．The PRC，PAC and AARR of the standing position of primary hypertension group was 6.80(11.90)pg/ml，121.20(31.94)pg/ml and 17.49(28.57)，whose recubent position results was 4.79(8.36)pg/ml，112.47(23.99)pg/ml and 22.67(37.43) at the same time．The AUC of the ROC of standing position for screening PA was 0.802．The sensitivity and specificity was 0.719 and 0.852 by using the cutoff value of 54.40．The AUC of the ROC of recumbent position for screening PA was 0.848．The sensitivity and specificity was 0.750 and 0.818 by using the cutoff value of 64.18．There was the same performace between the standing position and recumbent position for screening PA(P>0.05)．ConclusionThere is some application value to use AARR to screen primary aldosteronism．The performace between standing position and recumbent position was the same．

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备注/Memo

备注/Memo:
作者简介：吴子安(1980-)，男，硕士，主管技师，从事临床免疫检验学研究工作，E-mail：beancurd2002@hotmail.com。
更新日期/Last Update: 1900-01-01