[1]刘佩勇,谢梅,纪玉强,等.microRNA-155在病毒性心肌炎患者血清中的表达及临床意义[J].现代检验医学杂志,2015,30(05):46-49.[doi:10.3969/j.issn.1671-7414.2015.05.014]
　LIU Pei-yong,XIE Mei,JI Yu-qiang,et al.Changes of Serum Levels of MicroRNA-155 in the Patients with Viral Myocarditis and Their Clinical Significances[J].Journal of Modern Laboratory Medicine,2015,30(05):46-49.[doi:10.3969/j.issn.1671-7414.2015.05.014]
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microRNA-155在病毒性心肌炎患者血清中的表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
46-49
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Changes of Serum Levels of MicroRNA-155 in the Patients with Viral Myocarditis and Their Clinical Significances
作者:
刘佩勇; 谢梅; 纪玉强; 赵朝; 程曼丽
西安市第一医院心内科，西安710002
Author(s):
LIU Pei-yong; XIE Mei; JI Yu-qiang; ZHAO Zhao; CHENG Man-li
Department of Cardiovascular Medicine，the First Hospital of Xi’an City，Xi’an 710002，China
关键词:
病毒性心肌炎; microRNA-155; 临床意义; 肌钙蛋白T
分类号:
R542.21；Q503
DOI:
10.3969/j.issn.1671-7414.2015.05.014
文献标志码:
A
摘要:
目的探讨病毒性心肌炎患者(viral myocarditis)血清中microRNA-155(miR-155)的表达水平及其临床意义。方法采用定量逆转录聚合酶链反应(reverse transcription polymerase chain reaction，RT-PCR)检测38例病毒性心肌炎患者和38例健康体检者血清中miR-155的水平，采用电化学发光检测血清中肌钙蛋白T(cardiac troponin T，cTnT)的水平，统计分析miR-155与cTnT水平的相关性。结果病毒性心肌炎患者血清中miR-155水平为1.72±0.59，明显高于对照组血清中miR-155水平(1.27±0. 34)，二者差异具有统计学意义(t=4.074，P<0.01)；病毒性心肌炎患者血清中miR-155水平与cTnT呈明显正相关(r=0.624，P<0.05)。结论病毒性心肌炎患者血清中miR-155水平增高，且与心肌损伤程度相关，提示miR-155参与病毒性心肌炎的发生发展过程。
Abstract:
ObjectiveTo explore the serum levels microRNA-155 (miR-155) and their clinical significances in the patients with viral myocarditis．MethodsThe serum levels of miR-155 were detected by reverse transcription polymerase chain reaction (RT-PCR) in the 38 patients with viral myocarditis and 38 healthy controls．The serum levels of cardiac troponin T (cTnT) were detected by electrochemical luminescence method．The relationship between miR-155 and cTnT was analyzed by statistic analysis．ResultsCompared with healthy controls (1.27±0.34)，the serum levels of miR-155 in the patients with viral myocarditis (1.72±0.59) were statistically higher (t=4.074，P<0.01)．The serum levels of miR-155 were positive correlation with cTnT in the patients with viral myocarditis (r=0.624，P<0.05)．ConclusionThe serum levels of miR-155 in the patients with viral myocarditis were increased and related with the severity of myocardial injury．miR-155 may be involved in the occurrence and development of viral myocarditis．

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备注/Memo

备注/Memo:
基金项目：西安市科技计划项目［编号：SF1319(5)］。 作者简介：刘佩勇(1966-)，男，本科，主治医师，主要从事心血管内科工作，Tel：13891862038，E-mail：xadyyy@163.com。 通讯作者：纪玉强(1977-)，男，博士研究生，助理研究员，主要从事心血管疾病基础研究工作，Tel：13571992248，E-mail：jiyuqiang112299@126.com。
更新日期/Last Update: 1900-01-01