[1]詹颉,常宁宁,李小侠,等.CEA，AFP，CA125，CA199和CA72-4联合检测在鉴别卵巢良恶性疾病中的应用价值[J].现代检验医学杂志,2015,30(05):50-52.[doi:10.3969/j.issn.1671-7414.2015.05.015]
　ZHAN Jie,CHANG Ning-ning,LI Xiao-xia,et al.Clinical Value of Combined Detection of CEA，AFP，CA125，CA199 and CA72-4 in the Identification of Ovarian Benign and Malignant Disease[J].Journal of Modern Laboratory Medicine,2015,30(05):50-52.[doi:10.3969/j.issn.1671-7414.2015.05.015]
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CEA，AFP，CA125，CA199和CA72-4联合检测在鉴别卵巢良恶性疾病中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
50-52
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Clinical Value of Combined Detection of CEA，AFP，CA125，CA199 and CA72-4 in the Identification of Ovarian Benign and Malignant Disease
作者:
詹颉1; 常宁宁2; 李小侠1; 李芒会1; 张利侠1
1.陕西省人民医院检验科， 西安710068；2.延安大学医学院医学检验系，陕西延安716000
Author(s):
ZHAN Jie1; CHANG Ning-ning2; LI Xiao-xia1; LI Mang-hui1; ZHANG Li-xia1
1.Department of Clinical Laboratory，Shaanxi Provicial People’s Hospital，Xi’an 710068，China；2.Department of Medical Test，Yan’an University School of Medicine，Shaanxi Yan’an 716000，China
关键词:
卵巢癌; 卵巢良性肿瘤; 癌胚抗原; 甲胎蛋白; 糖类抗原125; 糖类抗原199; 糖类抗原72-4
分类号:
R737.31；R730.43
DOI:
10.3969/j.issn.1671-7414.2015.05.015
文献标志码:
A
摘要:
目的探讨肿瘤标志物CEA，AFP，CA125，CA199及CA72-4对卵巢良恶性疾病的鉴别诊断价值。方法选取2013年7月～2014年12月陕西省人民医院临床已经确诊的卵巢疾病患者132例，其中卵巢癌患者44例，卵巢良性肿瘤58例，卵巢囊肿30例，选择同期均排除其他妇科疾病的健康体检者58例作为对照组，采用罗氏cobas601仪器，电化学发光法定量检测研究对象中5项标志物，同时比较分析其检测结果的敏感度、特异度以及在不同卵巢疾病的差异。结果在各类卵巢疾病中，血清CEA，CA125和CA72-4水平组间比较差异有统计学意义(F=8.146～24.947，P=0.000)，AFP和CA199在不同组中含量差异无统计学意义(F=4.051～4.611，P＞0.001)；血清CEA，CA125和CA72-4的含量在卵巢癌和卵巢良性肿瘤差异有统计学意义(t=2.820～4.932，P=0.000～0.007)。5项指标联合检测在卵巢癌、卵巢良性肿瘤和卵巢囊肿的阳性率分别为75.0%，53.4%和53.3%，均高于单项检测的阳性率。CA125和CA72-4在卵巢癌与卵巢良性疾病中敏感度较高分别为54.5%和56.8%；CEA和AFP对卵巢癌、卵巢良性肿瘤和卵巢囊肿的特异度较高为100%。结论CA125，CA72-4是卵巢癌较理想的肿瘤标志物，但对卵巢疾病的筛查诊断特别是对于不同类型的卵巢疾病，联合检测能进一步提高其检出率。
Abstract:
ObjectiveTo investigate the diagnostic value of tumor markers CEA，AFP，CA125，CA199 and CA72-4 in the identification of ovarian benign and malignant diseases．MethodsSelected 132 patients with clinically diagnosed ovarian disease in Shaanxi Province People’s Hospital from July 2013 to December 2013．Among them，there were 44 cases of ovarian cancer patients，58 cases of ovarian benign tumor and 30 cases of ovarian cyst，and at same period，chose 58 cases of health examination as control group，that were ruled out other disease of department of gynaecology．Using Roche cobas 601 instruments and electro-chemical luminescence method to detect quantitatively the five markers．At the same time，compared and analysis the sensitivity of the test results，specific degrees，as well as differences in different ovarian disease．ResultsIn various ovarian disease，the difference of serum CEA，CA125 and CA72-4 between groups was statistically significant (F=8.146～24.947，P=0.000)，AFP and CA199 no statistically significant differences in content in different groups (F=4.051～4.611，P>0.001)．The difference of content of serum CEA，CA125，CA72-4 in ovarian and benign ovarian tumor difference was statistically significant (t=2.820～4.932，P=0.000～0.007)．Five indicators combined detection in ovarian cancer，ovarian benign tumor and the positive rate of ovarian cyst were 75.0%，53.4% and 53.3%，respectively，and positive rate were higher than single detection．CA125 and CA72-4 in ovarian cancer with ovarian benign disease high sensitivity were 54.5% and 56.8% respectively．CEA and AFP for ovarian cancer，ovarian benign tumors and ovarian cyst high specificity of 100%．ConclusionCA125 and CA72-4 were ideal tumor markers for ovarian cancer，but screening diagnosis of ovarian disease especially for different types of ovarian disease，combined detection can further improve the detection rate．

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备注/Memo

备注/Memo:
作者简介：詹颉(1971-)，女，主管检验师，现从事临床检验工作。 通讯作者：张利侠(1970-)，女，主任检验师，现从事临床感染与诊断治疗工作。
更新日期/Last Update: 1900-01-01