[1]刘斌a,龙延滨a,刘栋a,等.尿羧肽酶B和尿胰蛋白酶原激活肽诊断急性重症胰腺炎的临床价值分析[J].现代检验医学杂志,2015,30(05):81-83.[doi:10.3969/j.issn.1671-7414.2015.05.024]
　LIU Bina,LONG Yan-bina,LIU Donga,et al.Compare the Diagnostic Value of Carboxypeptidase(CAPAP) and the Urinary Trypsinogen(TAP) for Severe Acute Pancreatitis(SAP)[J].Journal of Modern Laboratory Medicine,2015,30(05):81-83.[doi:10.3969/j.issn.1671-7414.2015.05.024]
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尿羧肽酶B和尿胰蛋白酶原激活肽诊断急性重症胰腺炎的临床价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
81-83
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Compare the Diagnostic Value of Carboxypeptidase(CAPAP) and the Urinary Trypsinogen(TAP) for Severe Acute Pancreatitis(SAP)
作者:
刘斌a; 龙延滨a; 刘栋a; 刘倩b
1.陕西省人民医院 a.普外二科；b.消化内二科，西安710068
Author(s):
LIU Bina; LONG Yan-bina; LIU Donga; LIU Qianb
a.Second Department of General Surgery； b.Department of Digestive Diseases，Shaanxi Province People’s Hospital，Xi’an 710068，China
关键词:
急性重症胰腺炎; 尿羧肽酶; 尿胰蛋白酶原
分类号:
R576；R446.112
DOI:
10.3969/j.issn.1671-7414.2015.05.024
文献标志码:
A
摘要:
目的评估尿液中羧肽酶B激活肽(carboxypeptidase B，CAPAP)水平和尿胰蛋白酶原(trypsinpgen activation peptide，TAP)对急性重症胰腺炎(severe acute pancreatitis，SAP)的临床诊断价值。方法收集2012年6月~2014年6月因腹痛24~72 h就诊的病人，最终将23例SAP患者和38例急性轻症胰腺炎(mild acute pancreatitis，MAP)患者纳入研究，使用EPS速率法检测血清淀粉酶(amylase，Amy)水平，使用ELISA法检测尿液中TAP水平，使用胶体金法检测尿液中CAPAP水平，分别计算其诊断效能进而确定诊断效能最高的生化指标。结果研究共纳入61例患者，根据实验结果分析，SAP组尿液中CAPAP和TAP水平较MAP组均明显升高，CAPAP水平SAP组82.61%，MAP组为7.89%(P＜0.05)，TAP水平SAP组为93.62±14.61 nmol/L，MAP组为67.50±6.25 nmol/L，差异有统计学意义(P＜0.01)。血清Amy水平SAP组(744.31±689.64 u/L)与MAP组(549.32±338.33 u/L)差异无统计学意义(P＞0.05)。三项生化指标中，尿CAPAP对SAP最具有诊断价值(敏感度86.4%，特异度89.7%，准确度88.5%，阳性及阴性预测值分别为82.6%和78.8%)。结论相对于血清Amy和尿TAP，尿CAPAP可作为诊断SAP的一项可靠生化指标，血淀粉酶不适宜作为一项SAP的筛查指标。
Abstract:
ObjectiveTo assess the usefulness of the activation peptide of carboxypeptidase B (CAPAP) and urinary trypsinogen activation peptide (TAP) in the diagnosis of severe acute pancreatitis (SAP)．MethodsPatients with acute abdominal pain and hospitalized within 24～72 h after the onset of symptoms were prospectively studied from 2012.6 to 2014.6．They were divided into two groups：SAP (n=23)，MAP (n=38)．Serum amylase (Amy) was measured using a EPS．Urinary TAP was measured using a quantitative solid-phase ELISA，and urinary CAPAP by a radioimmunoassay method．Then，calculated its diagnostic performance to determine the highest diagnostic effectiveness biomarker．Results61 patients accomplished this study．Patients with severe acute pancreatitis showed significantly higher median levels of urinary CAPAP and TAP levels，the level of CAPAP in SAP was 82.61%，in MAP was 7.89% (P＜0.05)，the level of TAP in SAP was 93.62±14.61 nmol/L，in MAP was 67.50±6.25 nmol/L (P＜0.01)．There was no significance in serum Amylase (SAP 744.31±689.64 u/L，MAP 549.32±338.33 u/L，P＞0.05)．Urinary CAPAP was the most reliable test for the diagnosis of SAP (sensitivity 86.4%，specificity 89.7%，accuracy 88.5%，positive and negative predictive values 82.6% and 78.8%，respectively)．ConclusionIn patients with SAP，CAPAP in urine are reliable diagnostic markers．Amylase is not a useful screening test for the diagnosis of SAP．

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备注/Memo

备注/Memo:
作者简介：刘斌(1969-)，男，博士研究生，副主任医师，主要从事消化系肿瘤研究，Tel：029-85251331-3470，13572973928，E-mail：13572973928@163.com。
更新日期/Last Update: 1900-01-01