[1]孙树凯,田清武,刘入华,等.血清ProGRP,NSE和CEA检测对小细胞肺癌的诊断价值[J].现代检验医学杂志,2016,31(01):77-79.[doi:10.3969/j.issn.1671-7414.2016.01.022]
　SUN Shu-kai,TIAN Qing-wu,LIU Ru-hua,et al.Value of Serum ProGRP,NSE and CEA Detection in Diagnosis of Small Cell Lung Cancer[J].Journal of Modern Laboratory Medicine,2016,31(01):77-79.[doi:10.3969/j.issn.1671-7414.2016.01.022]
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血清ProGRP,NSE和CEA检测对小细胞肺癌的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
77-79
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Value of Serum ProGRP,NSE and CEA Detection in Diagnosis of Small Cell Lung Cancer
作者:
孙树凯1; 田清武1; 刘入华1; 申井利1; 翟玉娥1; 翟木绪2
1.青岛大学附属医院检验科,青岛 266555; 2.淄博市妇幼保健院内分泌科,山东淄博 255000
Author(s):
SUN Shu-kai1; TIAN Qing-wu1; LIU Ru-hua1; SHEN Jing-li1; ZHAI Yu-e1; ZHAI Mu-xu2
1.Department of Chinical Laboratory,the Affiliated Hospltal ofQingdao University, Qingdao 266555,China; 2.Department of Endocrinology, Zibo Maternal and Child Health Hospital,Shandong Zibo 255000,China
关键词:
胃泌素释放肽前体;  神经元特异性烯醇化酶;  癌胚抗原;  小细胞肺癌
分类号:
R734.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.01.022
文献标志码:
A
摘要:
目的 探讨血清胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)和癌胚抗原(CEA)联合检测对小细胞肺癌(SCLC)的诊断价值。方法471例肺部肿瘤患者均来自呼吸内科和胸外科住院患者,另从健康查体中心随机选取162例健康人作为对照组。所有研究对象均空腹采血,采用电化学发光法检测其血清ProGRP,NSE和CEA水平,绘制ROC曲线并计算曲线下面积(the area under the curve,AUC)。结果 SCLC患者血清ProGRP和NSE水平显著高于非小细胞肺癌组、肺良性病变组和正常对照组(P<0.01)。SCLC患者血清CEA水平显著高于肺良性病变组和正常对照组(P<0.05)。ProGRP,NSE 和CEA诊断SCLC的AUC分别为0.933,0.777和0.554。ProGRP,NSE和CEA诊断SCLC的敏感度分别为82.6%,60.4%和41.6%,特异度分别为95.2%,83.3%和71.7%。联合检测ProGRP,NSE和CEA诊断SCLC的敏感度为91.3%,特异度为65.3%。结论 血清ProGRP检测对SCLC具有较高的诊断价值; ProGRP,NSE和CEA的联合检测有助于SCLC的早期诊断。
Abstract:
Objective To investigate the diagnostic value of combined detection of serum gastrin-releasing peptide precursor(ProGRP),neuron specific enolization enzyme(NSE)and carcinoembryonicantigen(CEA)in small cell lung cancer(SCLC).Methods 471 patients with lung tumor from department of respiratory medicine and thoracic surgery and 162 healthypeople from medical examination center were studied.Serum levels of ProGRP,NSE and CEA were detected by using electrochemical luminescence method.ROC curveswere drawn and the area under the curve(AUC)was calculated.Results The levels of ProGRP and NSE were significantly higher in patientswith SCLC than those in NSCLC,lung benign disease group and normal control group(P<0.01).The levels of CEA were significantly higher in SCLC than thosein patients with lung benign disease group and normal control group(P<0.05).The AUC of ProGRP,NSE and CEA in the diagnosis of SCLC were 0.933,0.777and 0.554,respectively.The sensitivity of ProGRP,NSE and CEA in the diagnosis of SCLC were 82.6%,60.4%,41.6% and the specificity were 95.2%,83.3% and 71.7% respectively.The sensitivity of combined detection of ProGRP,NSE andCEA was 91.3% and the specificity was 65.3%.Conclusion The serum ProGRP detection has a higher diagnostic value for SCLC.The combined detection of ProGRP,NSE and CEA is useful in the early diagnosis of SCLC.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:孙树凯(1974-),男,硕士学位,副主任技师,研究方向:肿瘤标志物的临床应用,Tel:0532-82919305,E-mail:ssk0474@126.com。 通讯作者:翟木绪(1970-),男,博士学位,主任医师,E-mail:mxzhai@163.com。
更新日期/Last Update: 2016-01-20