[1]张高明,张国明,夏永杰.循环microRNA-499诊断AMI的Meta分析[J].现代检验医学杂志,2016,31(01):86-88.[doi:10.3969/j.issn.1671-7414.2016.01.025]
　ZHANG Gao-ming,ZHANG Guo-ming,XIA Yong-jie.Diagnostic Value of MicroRNA-499 for Acute Myocardial Infarction:a Meta-Analysis[J].Journal of Modern Laboratory Medicine,2016,31(01):86-88.[doi:10.3969/j.issn.1671-7414.2016.01.025]
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循环microRNA-499诊断AMI的Meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
86-88
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Diagnostic Value of MicroRNA-499 for Acute Myocardial Infarction:a Meta-Analysis
作者:
张高明1; 张国明1; 夏永杰2
1.沭阳县人民医院,江苏宿迁 223600; 2.复旦大学公共卫生学院,上海 200032
Author(s):
ZHANG Gao-ming1; ZHANG Guo-ming1; XIA Yong-jie2
1.Shuyang People's Hospital,Jiangsu Shuyang 223600,China; 2.School of Public Health,Fudan University,Shanghai 200032,China
关键词:
心肌梗死;  microRNA-499(MIR-499);  meta分析
分类号:
R542.22; R446
DOI:
10.3969/j.issn.1671-7414.2016.01.025
文献标志码:
A
摘要:
目的 评价循环microRNA-499(miR-499)对急性心肌梗死(acute myocardial infarction,AMI)的诊断价值。方法 检索万方,中国知网,NCBI,PubmMed,EMBSASE数据库2015年5月以前发表的关于miR-499诊断AMI的文献。以QUADAS工具对文献进行质量评价,采用meta-disc1.4软件进行统计分析miR-499诊断AMI的总体敏感度、特异度、阳/阴性似然比和诊断优势比。以SROC曲线分析miR-499诊断AMI的总体性能。结果 该次meta分析共纳入10项研究,其中国人研究7项,SCI文献7项。miR-499诊断AMI总体诊断敏感度为83%(95%CI:0.81～0.85),总体诊断特异度为81%(95%CI:0.78～0.83),总体诊断阳性似然比为4.53(95%CI:3.12～6.58),总体诊断阴性似然比为0.22(95%CI:0.14～0.33),总体诊断优势比为22.73(95%CI:10.78～47.93)。综合SROC曲线下面积(AUC)为0.90,Q值为0.84。结论 miR-499对AMI具有较高的诊断价值。
Abstract:
Objective To evaluate the diagnostic value of microRNA-499(miR-499)levels in acute myocardial infarction(AMI)diagnosis.Methods Retrieve Articles,Wanfang,China Knowledge Network,NCBI PubmMed,EMBSASE database 2010～2015 years met the inclusion criteria published abroad in relation to miR-499 diagnosis ten cases of human AMI literature.The quality of the sudies was evaluated by QUADAS tools through a comprehensive analysis of the random effects model effect size,the use of meta-disc 1.4 software for statistical analysis software.Results Ten studies met the included criteria.The summary estimates for miR-499 diagnosis of MI sensitivity was 83%(95% CI,0.81～0.85), specificity of 81%(95% CI,0.78～0.83),positive predictive value of 4.53(95% CI,3.12～6.58),negative predictive value was 0.22(95% CI,0.14～0.33),diagnostic odds ratio 22.73(95% CI,10.78～47.93).The area under the curve(AUC)for miR-499 was 0.90 with Q value of 0.84.Conclusion MiR-499 has highdiagnostic value for acute myocardial infarction.

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备注/Memo

备注/Memo:
作者简介:张高明(1967-),男,学士学位,副主任技师,研究方向生物化学与分子生物学。张国明,共同第一作者。 通信作者:张国明,E-mail:15151110055@163.com。
更新日期/Last Update: 2016-01-20