[1]薛 渊,徐 虹,沈 俐.女性HPV感染人群发生HIV感染风险的荟萃分析[J].现代检验医学杂志,2016,31(01):92-95.[doi:10.3969/j.issn.1671-7414.2016.01.027]
　XUE Yuan,XU Hong,SHEN Li.Human Papillomavirus Infection and Increased Risk of HIV Acquisition:A Meta-analysis of Case-control Studies[J].Journal of Modern Laboratory Medicine,2016,31(01):92-95.[doi:10.3969/j.issn.1671-7414.2016.01.027]
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女性HPV感染人群发生HIV感染风险的荟萃分析()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
92-95
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Human Papillomavirus Infection and Increased Risk of HIV Acquisition:A Meta-analysis of Case-control Studies
作者:
薛 渊,徐 虹,沈 俐
镇江市疾病预防与控制中心,江苏镇江 212001
Author(s):
XUE Yuan,XU Hong,SHEN Li
Zhenjing Center for Disease Control and Prevention,Jiangsu Zhengjiang 212001,China
关键词:
人类乳头状瘤病毒;  人类免疫缺陷病毒;  女性人群;  感染风险;  荟萃分析
分类号:
R373
DOI:
10.3969/j.issn.1671-7414.2016.01.027
文献标志码:
A
摘要:
目的 研究女性人群感染人类乳头瘤病毒(human papillomavirus,HPV)后继发人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染的风险。方法 检索Pubmed,EMBASE,Coehrane Library,中国知网,万方数据库,中国生物医学文献数据库等,按制定的纳入及排除标准筛选并评价文献质量。收集有关女性人群HPV感染后继发HIV感染的研究文献,由2名研究者独立提取数据并进行方法学评估,采用RevMan5.1软件进行荟萃分析。结果 纳入符合标准的文献共6篇,均为随机对照试验,研究对象共计9 606例。HPV感染的女性继发HIV感染的风险加倍(OR=2.02,95% CI:1.48～2.77)。其中高危型和低危型HPV感染患者发生HIV感染的相对危险度分别为OR=2.50,95% CI:1.73～3.61和OR=2.10,95% CI:1.48～2.96。结论 对所选取文献的荟萃分析提示HPV感染的女性患者继发HIV感染的风险增加,HPV疫苗可能对HIV感染有一定的预防作用。
Abstract:
Objective To evaluate the impact of human papillomavirus(HPV)infection on the risk of HIV acquisition in the female group.Methods Searched PubMed,EMbase,Coehrane Library,CNKI,wanfang database and Chinese Biomedical Literature Database etc for articles aboutHIV-acquisition in HPV infected female patients.The quality of the literaturewere evaluated according to standards of inclusion and exclusion.Data was extracted and methodologically quality evaluated by two independent investigators.Meta-analysis was accomplished using RevMan4.2 software.Results 6 articles were included,all of them were randomized controlled trials,a total of 9 606 cases studied.HIV infection risk was doubled in women with any HPV infection(OR=2.02,95% CI:1.48～2.77),demonstrating High-risk HPV-positive(OR=2.50,95% CI:1.73～3.61)and low-risk HPV-positive(OR=2.10,95% CI:1.48～2.96)respectively.Funnel plot analysis revealed no significant publication bias on HPV genotypes.Conclusion The analysisof selected research suggests the risk of HIV infection was increased in HPV-positive women.HPV vaccine may have some preventive effect on HIV infection.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:镇江市社会发展项目(SH2015083),镇江市卫生科技重点项目(SH2013096)。 作者简介:薛 渊(1983-),女,汉族,临床检验诊断学硕士,主管检验技师,主要从事微生物学研究,E-mail:xueyuan621@163.com。
更新日期/Last Update: 2016-01-20