[1]王苏梦,唐海霞,印中鹏,等.血浆抗凝血酶Ⅲ和血清降钙素原检测在腹腔感染诊断和预后中的临床价值[J].现代检验医学杂志,2016,31(02):22-25.[doi:10.3969/j.issn.1671-7414.2016.02.007]
　WANG Su-meng,TANG Hai-xia,YIN Zhong-peng,et al.Value of Detecting ATⅢ and Serum PCT Levels in Diagnosis and Prognosis of Abdominal Infection[J].Journal of Modern Laboratory Medicine,2016,31(02):22-25.[doi:10.3969/j.issn.1671-7414.2016.02.007]
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血浆抗凝血酶Ⅲ和血清降钙素原检测在腹腔感染诊断和预后中的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
22-25
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Value of Detecting ATⅢ and Serum PCT Levels in Diagnosis and Prognosis of Abdominal Infection
作者:
王苏梦; 唐海霞; 印中鹏; 汪俊军
南京军区南京总医院临床检验科,南京 210000
Author(s):
WANG Su-meng; TANG Hai-xia; YIN Zhong-peng; WANG Jun-jun
Department of Clinical Laboratory, Nanjing General Hospital of Nanjing Military Command,Nanjing210002,China
关键词:
腹腔感染;  抗凝血酶Ⅲ;  降钙素原;  诊断;  预后
分类号:
R572; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.02.007
文献标志码:
A
摘要:
目的 通过分析腹腔感染患者血浆抗凝血酶Ⅲ(ATⅢ)活性和血清降钙素原(PCT)的水平及相关性,探讨其在腹腔感染诊断和预后中的临床意义。方法 选取87例腹腔感染患者和49例健康对照者; 根据预后将腹腔感染患者分为预后良好组(69例)和预后不良组(18例); 分别检测两组腹腔感染患者及健康对照者的血浆ATⅢ活性和血清PCT水平,并分析其相关性。结果 腹腔感染患者血浆ATⅢ活性(70.1%±19.12%)显著低于健康对照者(76.5%±12.0%)(t=-5.823,P<0.001); 血清PCT水平[0.6(0.15～3.37)μg/L]显著高于健康对照者[0.05(0.03～0.06)μg/L](t=5.37,P<0.001)。在腹腔感染患者中,预后不良组的ATⅢ活性(54.45%±12.24%)显著低于预后良好组(74.14%±18.53%)(t=4.26,P<0.001); PCT水平[8.4(2.6～41.2)μg/L]显著高于预后良好组[0.29(0.13～1.20)μg/L](P<0.001)。相关性分析显示,腹腔感染患者血浆ATⅢ活性与血清PCT水平呈显著负相关(r=-0.495,P<0.001)。结论 联合检测血浆ATⅢ和血清PCT水平有助于临床腹腔感染患者的诊断及预后评估。
Abstract:
Objective This study was undertaken to investigate plasma ATⅢ,PCT levels and relationship of abdominal infection patients,and explore their clinical significance from inflammatory cytokines and coagulation system.Methods ATⅢ and PCT levels were determined in87 abdominal infection patients,49 healthy controls.The correlation analyse were performed.Results The level of ATⅢ in abdominal infection patients was(70.1%±19.12%)significantly lower than the level in healthy people(76.5%±12.0%,P<0.001).On the contrary,the level of PCT inabdominal infection patients 0.6(0.15～3.37)was significantly higher than the level in healthy people [0.05(0.03～0.06)μg/L,P<0.001].The levelof ATⅢ in abdominal infection patients was negatively correlated with the patients PCT, hs-CRP and WBC level(r=-0.495,-0.422,-0.326,P<0.001).Remarkably,the level of ATⅢ of poor prognosis patients(54.45%±12.24%)group was lower than the level of good prognosis patients group good prognosis(74.14%±18.53%,P<0.001).And the level of PCT in poor prognosis patients[8.4(2.6～41.2)μg/L] was significantly higher than the level in good prognosis patients [0.29(0.13～1.20)μg/L,P<0.001].In poor prognosis patients group,ATⅢ level significantly negatively correlates with PCT level(r=-0.519,P<0.001).Conclusion In peritoneal cavity infection patients,ATⅢ level was well-correlated with PCT and hs-CRP level.The combination of the three indexes detection could contribute to early diagnosis and prognosis evaluation of clinical peritoneal cavity infection.

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备注/Memo

备注/Memo:
作者简介:王苏梦(1984-),女,硕士,技师,研究方向:冠心病和炎症标志物。 通讯作者:汪俊军。
更新日期/Last Update: 2016-02-20