[1]岳金芳,丁卓奇.生长刺激表达基因2蛋白与动脉粥样硬化及脑梗死发病的关系研究[J].现代检验医学杂志,2016,31(02):68-69,72.[doi:10.3969/j.issn.1671-7414.2016.02.020]
　YUE Jin-fang,DING Zhuo-qi.Relationship of ST2 in the Atherosclerosis and Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2016,31(02):68-69,72.[doi:10.3969/j.issn.1671-7414.2016.02.020]
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生长刺激表达基因2蛋白与动脉粥样硬化及脑梗死发病的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
68-69,72
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Relationship of ST2 in the Atherosclerosis and Cerebral Infarction
作者:
岳金芳; 丁卓奇
新疆喀什地区第一人民医院重症医学一科,新疆喀什 844000
Author(s):
YUE Jin-fang; DING Zhuo-qi
Department of Intensive Medical, the First People's Hospital in Xinjiang Kashi Dirtric,Xinjiang Kashi 844000,China
关键词:
生长刺激表达基因2蛋白;  脑梗死;  动脉粥样硬化
分类号:
R743; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.02.020
文献标志码:
A
摘要:
目的 探讨生长刺激表达基因2蛋白(growth stimulationexpressed gene 2,ST2)水平与动脉粥样硬化及脑梗死发病的关系。方法 选取脑梗死患者100例,其中患者心功能I～II级43例,III～IV级57例。健康体检者80例为对照组,检测所有研究对象血清ST2水平,应用颈动脉多普勒彩色超声检查颈动脉内膜-中层厚度(intimal-medial wall thickness,IMT)。结果 脑梗死组ST2水平和IMT明显高于正常对照组(t=12.385～15.374,均P<0.05)。脑梗死患者有斑块组血清ST2水平58.74±5.81 ng/ml,颈动脉内膜1.89±0.41 mm。无斑块组ST2水平18.31±3.38 ng/ml,颈动脉内膜1.12±0.31 mm。两组差异有统计学意义(t=37.614～21.531,均P<0.05)。心功能Ⅰ～Ⅱ级脑梗死患者组ST2水平22.53±2.95 ng/ml,心功能Ⅲ～Ⅳ级脑梗死患者组ST2水平65.32±3.65 ng/ml,两组差异有统计学意义(t=55.148,P<0.05)。结论 血清ST2水平与颈动脉粥样硬化关系密切,可作为脑梗死及有无动脉粥样硬化发生的检测指标。
Abstract:
Objective To investigate the relationship of growth Stimulation expressed gene2(ST2)between the atherosclerosis and cerebralinfarction.Methods 100 patients with cerebral infarction(CI)were chosen,including 43 cases of Ⅰ-Ⅱ stage and 57 cases of Ⅲ-Ⅳ stage,and 80 cases healthy people of examination for the control group.The levelsof ST2 were measured,and measured the intimal-medial thickness(IMT)of internal carotid artery by carotid duplex ultrasonography scanning simultaneously.Results The levels of ST2 and IMT were significantly higherin the group of CI than those in control group(t=12.385～15.374,P<0.05).ST2 level of CI group with plaque was 58.74±5.81 ng/ml,and IMT was 1.89±0.41mm.Relatively,with no plaque was 18.31±3.38 ng/ml,and IMT was 1.12±0.31 mm.It were obvious differences for patients with cerebral infarction(CI)to detect ST2 level beween Ⅰ～Ⅱ stage and Ⅲ～Ⅳ stage of cardiac function(t=55.148,P<0.05).Conclusion There was a close correlation between ST2 level and atherosclerosis,and the ST2 level is a target todistinguish cerebral infarction whether or not with atherosclerosis.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:岳金芳(1981-),女,主治医师,主要从事临床重症疾病的诊疗工作。
更新日期/Last Update: 2016-02-20