[1]靳庆娥,谷俊朝,苏建荣.2015年北京地区孕前妇女血清TORCH抗体 及TNF-α水平检测与相关分析[J].现代检验医学杂志,2016,31(03):105-107.[doi:10.3969/j.issn.1671-7414.2016.03.029]
　JIN Qing-e,GU Jun-chao,SU Jian-rong.Seroprevalence of TORCH Infection Within Pre-Pregnancy Women and the Relationship with TNF-α Level During 2015 in Beijing Area[J].Journal of Modern Laboratory Medicine,2016,31(03):105-107.[doi:10.3969/j.issn.1671-7414.2016.03.029]
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2015年北京地区孕前妇女血清TORCH抗体 及TNF-α水平检测与相关分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
105-107
栏目:
论著
出版日期:
2016-06-15

文章信息/Info

Title:
Seroprevalence of TORCH Infection Within Pre-Pregnancy Women and the Relationship with TNF-α Level During 2015 in Beijing Area
文章编号:
1671-7414(2016)03-105-03
作者:
靳庆娥; 谷俊朝; 苏建荣
首都医科大学附属北京友谊医院检验科,北京 100050
Author(s):
JIN Qing-e; GU Jun-chao; SU Jian-rong
Department of Clinical Laboratory, Capital Medical University Affiliated Beijing Friendship Hospital,Beijing100050,China
关键词:
TORCH检测;  肿瘤坏死因子
分类号:
R373; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.03.029
文献标志码:
A
摘要:
目的 了解2015年北京地区育龄妇女TORCH感染情况,并探讨近期感染与TNF-α水平的关系。方法 采用ELISA法对2015年1月～12月进行孕检的970例妇女筛查TOX,RV,CMV,HSV-I,HSV-II IgM和IgG抗体。同时对IgM阳性妇女检测血清TNF-α水平,对结果进行统计分析。结果 孕前妇女TOX,RV,CMV,HSV-I和HSV-II IgM的阳性率分别为1.65%,2.16%,4.54%,17.42% 和 6.08%。IgG的阳性率依次是3.81%,93.40%,92.47%,64.02%和14.64%。<30岁妇女CMV和HSV-I IgM阳性率高于≥30岁妇女(χ2=4.558,4.051; 均P<0.05)。HSV-I型夏季感染率高于其他季节(χ2=5.356,P<0.05)。TORCH IgM阳性患者血清TNF-α水平高于正常体检组(t=10.219,P<0.01)。结论2015年北京地区孕前妇女TORCH感染率较高且有其流行特点,检测TNF-α水平对于生殖健康具有重要病理意义。
Abstract:
Objective To analysis TORCH pathogens infection of women in childbearing age in Beijing area,and to explore the relationshipof TORCH infection with the level of TNF-α.Methods Using ELISA detect serum IgM and IgG antibody of TOX,RV,CMV,HSV-I and HSV-II from 970 cases of women during Jan.2015 to Dec.2015.TNF-α levels of TORCH infection and control group were also determined by ELISA,the results were analyzed.Results Of 970 women,the IgM positive rates of TOX,RV,CMV,HSV-I and HSV-II were 1.65%,2.16%,4.54%,17.42% and 6.08%,respectively.The IgG positive rates of them were 3.81%,93.40%,92.47%,64.02%and 14.64% respectively.The positive rates of CMV and HSV-I IgM for women <30 years old were higher than that of ≥30 years old(χ2=4.558,4.051; P<0.05).HSV-I IgM had statistically higher infection rate in summer thanother seasons(χ2=5.356,P<0.05).TNF-α levels of TORCH IgM positive group were elevated compared with control group(t=10.219,P<0.01).Conclusion Women planning pregnancy were easier infected by TORCH in Beijing area during 2015 with specific epidemiological features.TNF-α also plays detrimental role during reproduction of childbearing age women.

参考文献/References:

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[3] 闫存玲,李志艳,刘 平,等.北京地区孕前及孕早期妇女TORCH感染情况调查[J].检验医学,2009,24(11):777-780. Yan CL,Li ZY,Liu P,et al.Investigation of TORCH infection amongwomen before pregnancy or in the early period of pregnancy in Beijing[J].Laboratory Medicine,2009,24(11):777-780.
[4] 陈延斌,吕 祺.TORCH抗体检测及其对优生优育的意义[J].中国优生与遗传杂志,2011,19(3):107,118. Chen YB,L(¨overu)Q.TORCH antibody detection and its significance in eugenics[J].Chinese Journal of Birth Health & Heredity,2011,19(3):107,118.
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备注/Memo

备注/Memo:
作者简介:靳庆娥(1981-),女,博士,助理研究员,主要从事病毒学分子诊断工作,Tel:010-63138717,E-mail:jinqinge@163.com。 通讯作者:苏建荣,女,主任医师,博士生导师,主要从事感染性疾病诊断方法及病原微生物耐药机制研究,Tel:010-63138550,E-mail:youyilab@163.com。
更新日期/Last Update: 2016-06-25