[1]张 华,詹 颉,苏宝凤,等.血清NGAL与肾功其它指标联合检测在原发性高血压肾病早期诊断中的应用[J].现代检验医学杂志,2016,31(04):54-57.[doi:10.3969/j.issn.16717-414.2016.04.014]
　ZHANG Hua,ZHAN Jie,SU Bao-feng,et al.Application of Detecting Serum NGAL Combined with Other Renal Function Index in Early Diagnosis of Essential Hypertension Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(04):54-57.[doi:10.3969/j.issn.16717-414.2016.04.014]
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血清NGAL与肾功其它指标联合检测在原发性高血压肾病早期诊断中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
54-57
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Application of Detecting Serum NGAL Combined with Other Renal Function Index in Early Diagnosis of Essential Hypertension Nephropathy
文章编号:
1671-7414(2016)04-054-04
作者:
张 华; 詹 颉; 苏宝凤; 闫福堂; 袁 军; 刘文康; 胡淑玲; 吕晓莉; 郑 霄
陕西省人民医院检验科,西安 710068
Author(s):
ZHANG Hua; ZHAN Jie; SU Bao-feng; YAN Fu-tang; YUAN Jun; LIU Wen-kang; HU Shu-ling;  Lv Xiao-li; ZHENG Xiao
Department of Clinical Laboratory, Shaanxi Provincial People's Hospital,Xi'an 710068,China
关键词:
血清;  中性粒细胞明胶酶相关脂质运载蛋白;  原发性高血压;  早期肾脏损害;  联合检测
分类号:
R544.11; R446.112
DOI:
10.3969/j.issn.16717-414.2016.04.014
文献标志码:
A
摘要:
目的 检测血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)浓度,探讨其与胱抑素 C(Cys-C)、视黄醇结合蛋白(RBP)、尿素(BUN)和肌酐(Cr)联合测定在原发性高血压早期肾脏损害中的应用价值。方法 选择2014年8月～2016年3月于陕西省人民医院就诊并经确诊的128例原发性高血压患者,将其分为单纯原发性高血压组、原发性高血压并发肾病组和原发性高血压并发肾衰组,同时选择100例健康体检者作为对照组。采用日立7170A全自动生化分析仪对各组血清NGAL与Cys-C,RBP,BUN和Cr水平进行检测,其结果进行统计学分析。结果 各组血清NGAL,Cys-C,RBP,BUN和Cr的检测结果中,单纯原发性高血压组与正常对照组之间差异均无统计学意义(P均>0.05); 原发性高血压并发肾病组与正常对照组、单纯原发性高血压组比较差异均有统计学意义(P均<0.05); 原发性高血压并发肾病组和原发性高血压并发肾衰组血清NGAL与正常对照组、单纯原发性高血压组差异均有统计学意义(P均<0.01); 而原发性高血压并发肾病组NGAL与Cys-C之间差异无统计学意义(P>0.05)。各组NGAL,Cys-C,RBP,BUN和Cr检测异常率方面,原发性高血压并发肾病组均显著高于正常对照组和单纯原发性高血压组,差异有统计学意义(P均<0.01),但BUN,Cr远低于原发性高血压并发肾病组NGAL的异常率(P<0.01)。而原发性高血压并发肾衰组的NGAL,Cys-C,RBP,BUN和Cr异常率略有差异,但差异均无统计学意义(P>0.05)。结论血清NGAL的检测在原发性高血压肾病早期诊断中具有重要的意义,如果联合肾功其它指标的检测可为临床诊断和评估原发性高血压早期肾脏损害以及损害的程度提供重要依据。
Abstract:
Objective To investigate clinical application value of detectiing serum NGAL combined with Cys-C,RBP,BUN and Cr in primary pypertension patients with early renal damage.Methods Selection of 128 patients with essential hypertension who were diagnosed in Shaanxi Provincial People's Hospital from August 2014 to March 2016.Selected 128 cases ofessential hypertension patients diagnosed clinically,which could be divided into simple essential hypertension group,essential hypertension with nephropathygroup and essential hypertension with renal failure group,and while 100 cases of healthy persons was as normal control group.The serum NGAL,Cys-C,RBP,BUNand Cr in each group were determined with Hitachi 7170A Automatic Biochemical Analyzer,and the measured data were processed by statistical analysis.Results In the detection results of serum NGAL,Cys-C,RBP,BUN and Cr,compared each group,there was not statistical difference in the simple essential hypertension group and the normal control group(P>0.05),but there were statistical differences in the essential hypertension with nephropathy group and the normal control group,and the simple essential hypertension group(P< 0.05).Serum NGAL,there were statistical differences in the essential hypertension with nephropathy group,the essential hypertension with renal failure group and simple essential hypertension group,the normal control group,but there was no statistical difference between NGAL and Cys-C essential hypertension with nephropathy group(P>0.05).The positive rates of NGAL,Cys-C,RBP,BUN and Cr in each group,the essential hypertension with nephropathy group was significantly higher than the normal control group and the simple essential hypertension group(P<0.01),but positive rates of BUN,Cr were far less than the positive rate of NGAL in essential hypertension with nephropathy group(P<0.01).The positive rates of the serum NGAL,Cys-C,RBP,BUN and Cr in thethe essential hypertension with renal failure group had slight difference,butno statistical significance(P>0.05).Conclusion Detection of serum NGAL is of great significance for the early diagnosis of essential hypertension with nephropathy.If the detection combined with other renal function indexes,it can provide an important basis for clinical diagnosis and assessment of essential hypertension with early kidney damage and damage degree.

参考文献/References:

[1] Hill GS.Hypertensive nephrosclerosis[J].Curr Opin Nephrol Hypertens,2008,17(3):266-270.
[2] 侯 菲,缪洁萍,蔡红梅,等.原发性高血压患者血和尿中性粒细胞明胶酶相关脂质运载蛋白的改变及临床意义[J].首都医科大学学报,2016,34(4):605-608. Hou F,Miao JP,Cai HM,et al.Changes of neutrophil gelatinase-associated lipocalin in patients with its primary hypertensive and its clinical significance[J].Journal of Capital Medical University,2016,34(4):605-608.
[3] Rosario RF,Wesson DE.Primary hypertension and nephropathy[J].Curr Opin Nephrol Hypertens,2006,15(2):130-134.
[4] 薛志强,童俊容.慢性肾脏疾病血清和尿液NGAL的改变及其临床意义[J].中国中西医结合肾病杂志,2010,11(5):440-441. Xue ZQ,Tong JR.Changes of NGAL in serum and urine of patients withchronic kidney disease and their clinical significance[J].Chinese Journal ofIntegrated Traditional and Western Nephrology,2010,11(5):440-441.
[5] Flower DR, North AC, Sansom CE.The lipocalin protein family:structural and sequence overview[J].Biochim Biophys Acta,2000,1482(1/2):9-24.
[6] Bagshaw SM,Bennett M,Devarajan P,et al.Urine biochemistry in septic and non-septic acute kidney injury:a prospective observational study[J].J Crit Care,2013,28(4):371-378.
[7] Meldrum KK,Hile K,Meldrum DR,et al.Simulated ischemia induces renal tubular cell apoptosis through a nuclear factor-κB dependent mechanism[J].JUrol,2002,168(1):248-252.
[8] Paragas N,Qiu A,Hollmen M,et al.NGAL-Siderocalin in kidney disease[J].Biochim Biophys Acta,2012,1823(9):1451-1458.
[9] Yang HN,Boo CS,Kim MG,et al.Urine neutrophil gelatinase associated lipocalin:an independent predictor of adverse outcomes in acute kidney injury[J].Am J Nephrol,2010,31(6):501-509.
[10] 姜昌丽,王惠萱,牛军州,等.血清胱抑素C在高血压早期肾损害诊断中的临床应用[J].现代检验医学杂志,2013,28(1):130-132. Jiang CL,Wang HX,Niu JZ,et al.Clinical application of serum cystatin Cin early renal damage of hypertension[J].Journal of Modern Laboratory Medicine,2013,28(1):130-132.
[11] 彭俊华,张全华,赵 勇,等.血清β2-MG,Cys-C及U-mALB在高血压肾损伤中的应用[J].现代检验医学杂志,2014,29(4):147-149. Peng JH,Zhang QH,Zhao Y,et al.Clinical application of β2 macroglobulin,cystatin C and urinary albumin in diagnosis of hypertensive renal injury[J].Journal of Modern Laboratory Medicine,2014,29(4):147-149.
[12] Weinert LS,Prates AB,do Amaral FB,et al.Gender does not influence cystatin C concentrations in healthy volunteers[J].Clin Chem Lab Med,2010,48(3):405-408.
[13] Alvelos M, Pimentel R, Pinho E,et al.Neutrophil gelatinase associated lipocalin in the diagnosirs of type 1 cardio-renal syndrome in the general ward[J].Clin J Am Soc Nephrol,2011,6(3),476-481.
[14] Padhy M,Kaushik S,Girish MP,et al.Serum neutrophil gelatinase associated lipocalin(NGAL)and cystatin C as early predictors of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention[J].Clin Chim Acta,2014(435):48-52.

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备注/Memo

备注/Memo:

作者简介:张 华(1966-),女,大专,主管检验技师,从事检验医学工作,特别在临床化学检验方面有一定的造诣。
通讯作者:詹 颉,主管检验师,E-mail:34758581@qq.com。
更新日期/Last Update: 2016-08-10