[1]熊 娟,丁 园,张 敬,等.XRCC2基因R188H位点多态性与大肠癌易感性的Meta分析[J].现代检验医学杂志,2016,31(04):70-73.[doi:10.3969/j.issn.16717-414.2016.04.018]
　XIONG Juan,DING Yuan,ZHANG Jing,et al.Association between XRCC2 R188H Polymorphism and Risk of Colorectal Cancer:A Meta-Analysis[J].Journal of Modern Laboratory Medicine,2016,31(04):70-73.[doi:10.3969/j.issn.16717-414.2016.04.018]
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XRCC2基因R188H位点多态性与大肠癌易感性的Meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
70-73
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Association between XRCC2 R188H Polymorphism and Risk of Colorectal Cancer:A Meta-Analysis
文章编号:
1671-7414(2016)04-070-04
作者:
熊 娟; 丁 园; 张 敬; 杨 昊; 彭 沛
汉川市人民医院检验科,湖北汉川 431600
Author(s):
XIONG Juan; DING Yuan; ZHANG Jing; YANG Hao; PENG Pei
Department of Clinical Laboratory,the People's Hospital of Hanchuan,Hubei Hanchuan 431600,China
关键词:
X射线交错互补修复基因2;  R188H;  基因多态性;  大肠癌;  Meta分析
分类号:
R735.34; R730.43
DOI:
10.3969/j.issn.16717-414.2016.04.018
文献标志码:
A
摘要:
目的 通过系统性回顾性分析评价X射线交错互补修复基因2(XRCC2)基因多态性与大肠癌易感性的相关性,以期为大肠癌的临床诊断提供相应参考。方法 计算机检索知网、万方、PubMed,Embase,WebofScience和CNKI数据库,2000年1月～2015年12月XRCC2基因R188H多态性与大肠癌的病例对照研究,应用RevMan5.3及Stata软件进行定量分析。结果 共纳入5篇病例-对照研究:大肠癌病例组2 106例,正常对照组2 607例。Meta分析结果显示,XRCC2 R188H基因多态性与大肠癌发病风险的差异无统计学意义。GA vs GG基因型[OR=1.08,95%CI(0.92～1.27),P=0.36]。AA vs GG 基因型[OR=1.26,95% CI(0.81～1.97),P=0.31]。GA+AA vs GG基因型[OR=1.04,95% CI(0.87～1,23),P=0.69]。AAvs GG+GA基因型[OR=1.26,95%CI(0.81～1.96),P=0.31]。结论 XRCC2 R188H基因多态性与大肠癌易感性无关,而进一步的验证则仍需要更大样本的多中心随机化对照试验进行研究。
Abstract:
Objective To investigate the association between X-ray repair complementing gene 2(XRCC2)gene polymorphism and the Colorectal Cancer susceptibility.And to provide the evidence for the diagnosis of the Colorectal Cancer.Methods Related literatures published from January 2000 to December 2015 in the CNKI,Wanfang,PubMed,EMbase and Web ofScience were included in this study.RevMan 5.3 and Stata software was used for the quantitative analysis.Results Five case-control studies were included in this study,including 2 106 cases with carcinoma of large intestine and 2 607 control.Meta analysis revealed XRCC2 polymorphism was notassociated with the risk of Colorectal Cancer.GA vs GG model[OR=1.08,95%CI(0.92～1.27),P=0.36].AA vs GG model[OR=1.26, 95%CI(0.81～1.97),P=0.31].GA+AA vs GG model [OR=1.04,95%CI(0.87～1,23),P=0.69].AAvs GG+GA model [OR=1.26,95% CI(0.81～1.96),P=0.31].Conclusion XRCC2 R188H polymorphism was not associated with ColorectalCancer.And further studies are still needed to confirm the result.

参考文献/References:

[1] Cetinkunar S,Gok I,Celep RB,et al.The effect of polymorphismin DNA repair genes RAD51 and XRCC2 in colorectal cancer in Turkish population[J].Int J Clin Exp Med,2015,8(2):2649-2655.
[2] Yang CH,Lin YD,Yen CYet al.A systematic gene-gene and gene-environment interaction analysis of DNA repair genes XRCC1,XRCC2,XRCC3,XRCC4,and oralcancer risk[J].OMICS,2015,19(4):238-247.
[3] Michalska MM,Samulak D,Romanowicz H,et al.Single nucleotide polymorphisms(SNPs)of RAD51-G172T and XRCC2-41657C/T homologous recombination repair genes and the risk of triple-negative breast cancer in polish women[J].PatholOncol Res,2015,21(4):935-940.
[4] Qureshi Z,Mahjabeen I,Baig R,et al.Correlation between selected XRCC2,XRCC3 and RAD51 gene polymorphisms and primary breast cancer in women in Pakistan[J].Asian Pac J Cancer Prev,2014,15(23):10225-10229.
[5] Cetinkunar S,Gok I,Celep RB,et al.The effect of polymorphism in DNArepair genes RAD51 and XRCC2 in colorectal cancer in Turkish population[J].Int J Clin Exp Med,2015,8(2):2649-2655.
[6] Curtin K,Lin WY,George R,et al.Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis[J].Cancer Epidemiol Biomarkers Prev,2009,18(9):2476-2484.
[7] Tranah GJ,Giovannucci E,Ma J,et al.XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma[J].Cancer Epidemiol Biomarkers Prev,2004,13(6):1090-1091.
[8] Krupa R,Sliwinski T,Wisniewska-Jarosinska M,et al.Polymorphisms in RAD51,XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer- a case control study[J].Mol Biol Rep,2011,38(4):2849-2854.
[9] Moreno V,Gemignani F,Landi S,et al.Polymorphisms in genes of nucleotide and base excision repair:risk and prognosis of colorectal cancer[J].Clin Cancer Res,2006,12(7pt1):2101-2108.
[10] 王钦君,张红春,申娴娟,等.MicroRNAs作为结直肠癌潜在标志物的研究进展[J].现代检验医学杂志,2015,30(4):107-110,114. Wang QJ,Zhang HC,Shen XJ,et al.MicroRNAs as a potential marker in theprogress of colorectal cancer[J].J Mod Lab Med,2015,30(4):107-110,114.
[11] Griffin CS,Simpson PJ,Wilson CR,et al.Mamma-lian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation[J].Nat CellBiol,2000,2(10):757-761.
[12] 范秀秀.XRCC 2和XRCC 3在大肠癌及大肠息肉中表达的临床意义[J].当代医学,2014,20(29):1-3. Fan XX.Clinical significance of XRCC2 and XRCC3 expression in colorectalcarcinoma and colorectal polyps[J].Contemporary Medicine,2014,20(29):1-3.
[13] 王 芹,王敬敏,徐 畅.沉默XRCC2基因表达联合电离辐射对结肠癌细胞增殖能力的影响[J].国际放射医学核医学杂志,2015,39(4):282-286. Wang Q,Wang JM,Xu C.The effect of silencing XRCC2 gene combined with ionizing radiation on growth of colorectal cancer cells[J].Int J Radiat Med Nucl Med,2015,39(4):282-286.

备注/Memo

备注/Memo:

作者简介:熊 娟(1977-),女,武汉大学工程硕士研究生,副主任技师,研究方向:临床生物化学和临床免疫学,Tel:13871922260, E-mail:xjildk0203@163.com。
更新日期/Last Update: 2016-08-10