[1]叶永红,陈月兰,詹禧奎,等.联合检测Ficolin-3,TRF及hs-CRP对2型糖尿病早期诊断价值[J].现代检验医学杂志,2016,31(04):74-76，79.[doi:10.3969/j.issn.16717-414.2016.04.019]
　YE Yong-hong,CHEN Yue-lan,ZHAN Xi-kui,et al.Early Diagnostic Value of Combined Detection of Ficolin-3, TRF and hs-CRP for Type 2 Diabetes[J].Journal of Modern Laboratory Medicine,2016,31(04):74-76，79.[doi:10.3969/j.issn.16717-414.2016.04.019]
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联合检测Ficolin-3,TRF及hs-CRP对2型糖尿病早期诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
74-76，79
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Early Diagnostic Value of Combined Detection of Ficolin-3, TRF and hs-CRP for Type 2 Diabetes
文章编号:
1671-7414(2016)04-074-04
作者:
叶永红; 陈月兰; 詹禧奎; 宋柯瑶
深圳市福田人民医院八卦岭社康,广东深圳 518029
Author(s):
YE Yong-hong; CHEN Yue-lan; ZHAN Xi-kui; SONG Ke-yao
Ba Gualing Club Health Center, Futian People's Hospital of Shenzhen,Guangdong Shenzhen 518029,China
关键词:
2型糖尿病;  纤维凝胶蛋白-3;  转铁蛋白;  超敏C反应蛋白
分类号:
R587.1; R446.112
DOI:
10.3969/j.issn.16717-414.2016.04.019
文献标志码:
A
摘要:
目的 探讨联合检测血清纤维凝胶蛋白-3(Ficolin-3)、转铁蛋白(TRF)及超敏C反应蛋白(hs-CRP)对2型糖尿病(T2DM)的早期诊断价值。方法 选取深圳福田人民医院2013年10月～2015年10月收治的T2DM前期患者80例[空腹血糖受损(IFG)35例,糖耐量减低(IGT)45例]为A组,另外选取健康体检人群55例为B组,测定研究对象血清Ficolin-3,TRF及hs-CRP水平,评估其对于T2DM的早期诊断价值。结果 A组患者Ficolin-3,TRF及hs-CRP水平明显高于B组(27.4±2.5 μg/ml vs 18.9±2.3 μg/ml,277±12.7 mg/dl vs 219±9.8 mg/dl,3.68±0.74 mg/ml vs 1.23±0.83 mg/ml),差异具有统计学意义(P<0.05); 单独检测,对早期T2DM诊断的特异度和阳性预测值由高到低依次为TRF>Ficolin-3>hs-CRP(63.7%>54.5%>36.4%,72.2%>70.5%>50.7%),敏感度和阴性预测值由高到低为Ficolin-3>TRF>hs-CRP(70.0%>65.0%>45.0%,60.0%>55.6%>31.3%); 以串联方式检测,检测Ficolin-3,TRF及hs-CRP对早期T2DM的诊断特异性显著提高(89.5%),以并联方式检测,检测Ficolin-3,TRF及hs-CRP对早期T2DM的诊断敏感性显著提高(94.2%)。结论 联合检测血清Ficolin-3,TRF及hs-CRP对T2DM早期诊断具有重要价值,可有效提高早期T2DM诊断的特异度和灵敏度,值得临床推广。
Abstract:
Objective To explore the early diagnosticvalue of combined detection of Ficolin-3,TRF and hs-CRP for type 2 diabetes(T2DM).Methods 80 cases of pre-T2DM patients in Shenzhen Futian People's Hospital were collected as group A [impaired fasting glucose(IFG)35 cases of impaired glucose tolerance(IGT)45 cases)] from October 2013 to October 2015,55 cases of healthy people were incontrol group B.Serum Ficolin-3,TRF and hs-CRP levels of patients in two were test,evaluate the earlydiagnostic value of type 2 diabetes(T2DM).Results TheFicolin-3,TRF and hs-CRP levels of patients in A group were significantly higher than those in group B(27.4±2.5 μg/ml vs 18.9 ± 2.3 μg/ml,277±12.7 mg/dl vs 219±9.8 mg/dl,3.68±0.74 mg/ml vs 1.23±0.83 mg/ml),the difference was statistically significant(P<0.05).Individually tested,specificity and positive predictive value of early diagnosis of T2DM in descending order of TRF>Ficolin-3>hs-CRP(63.7%> 54.5%>36.4%,72.2%>70.5%>50.7%),the sensitivity and negative predictive value from high to low Ficolin-3>TRF>hs-CRP(70.0%>65.0%>45.0%,60.0%>55.6%>31.3%).In series testing,testFicolin-3,TRF and hs-CRP for early diagnosis of T2DM significantly increasedsignificantly(89.5%),in parallel testing,the sensitivity of testing Ficolin-3,TRF and hs-CRP for early diagnosis of T2DM improved significantly(94.2%).Conclusion Combined detection of serum Ficolin-3,TRFand hs-CRP is valuable for the early diagnosis of type 2 diabetes,and can improve the specificity and sensitivity of early diagnosis of T2DM effectively.It should be popularized.

参考文献/References:

[1] 王会奇,何松明,李东升,等.2型糖尿病患者181例社区跟踪十年并发症和合并症及治疗情况变化分析[J].中国全科医学,2012,15(36):4212-4215. Wang HQ,He SM,Li DS,et al.A 10-years' dynamic analysis of accompanying diseases,complications and their treatments among 181 T2DM patients inour community[J].Chinese General Practice,2012,15(36):4212-4215.
[2] 冯 丹,王 贞,曹华军,等.Ficolin-3,TRF及hs-CRP联合检测在2型糖尿病早期诊断中的价值[J].昆明医科大学学报,2015,36(7):13-16. Feng D,Wang Z,Cao HJ,et al.Application of measurements of serumFicolin-3,TRF and hs-CRP in the early identification of type 2 diabetes mellitus[J].Journal of Kunming Medical University,2015,36(7):13-16.
[3] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华内分泌代谢杂志,2014,30(10):893-942. Chinese Diabetes Society.Complications Chinese type 2 diabetes prevention guide(2013 edition)[J].Chinese Journal of Endocrinology and Metabolism,2014,30(10):893-942.
[4] 谈 昀,李军民,曾宪飞,等.血清胱抑素C与β2微球蛋白、尿微量清蛋白检测在2型糖尿病肾病早期诊断中的相关研究[J].现代检验医学杂志,2011,26(2):107-108,111. Tan Y,Li JM,Zeng XF,et al.Discussin of cystatin C and β2-MG,Malbassay in the diagnosis of earlyrenai damage in type 2 DM[J].Journal ofModern Laboratory Mediciine,2011,26(2):107-108,111.
[5] 徐 瑜,毕宇芳,王卫庆,等.中国成人糖尿病流行与控制现状-2010年中国慢病监测暨糖尿病专题调查报告解读[J].中华内分泌代谢杂志,2014,30(3):184-186. Xu Y,Bi YF,Wang WQ,et al.Prevalence and control of diabetes in Chinese adults-the interpretation of a 2010 China Noncommunicable Disease Surveillance report[J].Chinese Journal of Endocrinology and Metabolism,2014,30(3):184-186.
[6] 胡纪文,熊建辉,张永顶.免疫印迹试验检测血清胰岛自身抗体的应用价值[J].重庆医学,2013,42(20):2413-2414. Hu JW,Xiong JH,Zhang YD.Application value of western blot(WB)inserum islet autoantibodies[J].Chongqing Medicine,2013,42(20):2413-2414.
[7] 郭江涛,曹旭晴,王志军.Ficolin 3的表达、纯化及其对RAW264.7巨噬细胞的活化作用[J].细胞与分子免疫学杂志,2014,30(7):677-680. Guo JT,Cao XQ,Wang ZJ.Expression and purification 3 and its rolefor RAW264.7 macrophage activation in vitro[J].Chinese Journal of Cellular and Molecule,2014,30(7):677-680.
[8] 任 静,张朝明,熊大迁.内脂素与2型糖尿病及相关肾病的关系研究进展[J].现代检验医学杂志,2013,28(6):139-141. Ren J,Zhang ZM,Xiong DQ.Research progression of the relationshipbetween visfatin and type 2 diabetes and diabetic microangiopathy[J].Journalof Modern Laboratory Medicine,2013,28(6):139-141.
[9] Lu J,Li M,Zhang R,et al.A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population[J].Clinical andExperimental Hypertension,2012,34(5):377-382.
[10] 涂 盛,邵安文,叶 真,等.肝源性糖尿病发病机制研究进展[J].中华肝脏病杂志,2014,22(1):78-80. Tu S,Shao AW,Ye Z,et al.Advances in understa-nding the pathogenesis of hepatogenic diabetes[J].Chinese Journal of Hepatology,2014,22(1):78-80.
[11] Wu W,Li Q,Xia J,et al.Effects of the glucose-lowering rate on cTnIand hs-CRP serum levels in type 2 diabetics[J].Human Immunology,2013,74(3):379-382.
[12] 付冬霞,王光亚,许金秀,等.血清铁蛋白在妊娠期糖尿病患者中的水平及其与胰岛素抵抗的关系[J].中国全科医学,2012,15(33):3827-3830. Fu DX,Wang GY,Xu JX,et al.Level of serum ferritin in gestational diabetes mellitus and its relationship with insulin resistance[J].Chinese GeneralPractice,2012,15(33):3827-3830.
[13] 吴伟华,孙振杰,孙丽芳,等.降糖过程中2型糖尿病患者心肌肌钙蛋白Ⅰ及超敏C反应蛋白水平的变化[J].中华内分泌代谢杂志,2011,27(10):800-804. Wu WH,Sun ZJ,Sun LF,et al.Changes of high se-nsitive-C reactive protein and cardiac troponin I levels in patients with type 2 diabetes during glucose-lowering therapy[J].Chinese Journal of Endocrinology and Metabolism,2011,27(10):800-804.

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备注/Memo

备注/Memo:

作者简介:叶永红(1978-),男,本科,主治医师,研究方向:临床医学检验技术,E-mail: songlinglp@163.com。
更新日期/Last Update: 2016-08-10