[1]阿地拉·阿布里孜,古兰木拜尔·安尼瓦尔.心功能不全透析患者检测纤维蛋白单体的临床意义[J].现代检验医学杂志,2016,31(04):149-150.[doi:10.3969/j.issn.1671-7414.2016.04.043]
　ADILA·Abulizi,GULANMUBAIER·Anniwaner.Clinical Significance of Detection Fibrin Monomer in Hemodia Lysis with Cardiac Insufficiency Patients[J].Journal of Modern Laboratory Medicine,2016,31(04):149-150.[doi:10.3969/j.issn.1671-7414.2016.04.043]
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心功能不全透析患者检测纤维蛋白单体的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
149-150
栏目:
检验与临床
出版日期:
2016-08-10

文章信息/Info

Title:
Clinical Significance of Detection Fibrin Monomer in Hemodia Lysis with Cardiac Insufficiency Patients
文章编号:
1671-7414(2016)04-149-02
作者:
阿地拉·阿布里孜1; 古兰木拜尔·安尼瓦尔2
1.新疆维吾尔自治区人民医院肾病科,乌鲁木齐 830001;
2.乌鲁木齐市友谊医院肾病科,乌鲁木齐 830000)
Author(s):
ADILA·Abulizi1; GULANMUBAIER·Anniwaner2
1.Department of Nephropathy,Xinjiang Uygur Autonomous Region People's Hospital,Urumqi 830001,China;
2.Department of Nephropathy,Urumqi Youyi Hospital,Urumqi 830000,China
关键词:
血液透析;  心功能不全;  D-二聚体;  纤维蛋白单体
分类号:
R541; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.04.043
文献标志码:
A
摘要:
目的 探讨血液透析患者检测纤维蛋白单体的临床意义。方法 血液透析患者按活动性分级为Ⅰ～Ⅱ级22例,Ⅲ～Ⅳ级38例。对不同心功能级的血液透析患者及正常对照组进行血浆凝血酶原时间(PT),活化的部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fg)、D-二聚体(D-dimer)和纤维蛋白单体(FM)定量检测并进行统计学分析。结果 血液透析患者心功能Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组分别与对照组比较TT,PT,APTT和Fg水平差异无统计学意义(t=0.33～0.58,均P>0.05),D-二聚体和FM水平差异有统计学意义(t=6.15～7.45,t=8.41～11.65,均P<0.05)。心功能Ⅲ～Ⅳ级组D-二聚体水平比心功能Ⅰ～Ⅱ级组高,但两组差异无统计学意义(t=0.38,P>0.05)。FM水平差异有统计学意义(t=12.35,P<0.05)。结论 FM是透析患者心功能不全早期诊疗的敏感指标。
Abstract:
Objective To investigate the clinical significance and level changes of Fibrin Monomer on Hemodialysis with cardiac insufficiency patients.Methods According to cardiac function,the Hemodialysis patients were divided into Ⅰ～Ⅱ grade(22 cases),Ⅲ～Ⅳ grade(38cases).They were detected blood coagulation factor(PT,APTT and TT),fibrinogen(Fg),D-dimer and Fibrin Monomer(FM).Results There were no obvious differences of PT,APTT,TT and Fg levels between patients and normal group(t=0.33～0.58,P>0.05),and obvious differences of D-dimer and FM(t=6.15～7.45,t=8.41～11.65,P<0.05).The level of D-DI between cardiac insufficiency patients of Ⅰ～Ⅱ stage and Ⅲ～Ⅳ stage were no differences(t=0.38,P>0.05).The complicated with cardiac insufficiency groupof Ⅲ～Ⅳ stage had a higher FM levels than those of Ⅰ～Ⅱ stage(t=12.35,P<0.05).Conclusion Detection of FM could be a more sensitive marker for diagnosing and treatment to Hemodialysis patients with cardiac insufficiency.

参考文献/References:

[1] Hung KC,Wu CC,Chen HS,et al.Serum IL-6,albumin and co-morbidities are closely correlated with symptoms of depression in patients on maintenance haemodialysis[J].Nephrol Dial Transplant,2011,26(2):658-664.
[2] Torbicki A,Perrier A,Konstantinidess S,et al.Gui-delines on the diagnosis and management of acute pulmonary embolism[J].Eur Heart J,2008,29(11):2276-2315.
[3] 李 胜,阎敏娜,李 伟,等.血液透析患者凝血状态变化的研究[J].医学综述,2014,20(5):952-953. Lin S,Yan MN,Li W,et al.Research of prothrombotic changes in patients with Hemodialysis[J].Medical Recapitulate,2014,20(5):952-953.

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备注/Memo

备注/Memo:

作者简介:阿地拉·阿布里孜(1974-),女,维族,硕士学位,副主任医师,主要从事血液透析患者诊疗。
更新日期/Last Update: 2016-08-10