[1]王 慧,王 博,郭 瑄.Toll样受体4和单核细胞趋化蛋白1与急性冠脉综合征的关系研究[J].现代检验医学杂志,2016,31(05):84-87.[doi:10.3969/j.issn.1671-7414.2016.05.022]
　WANG Hui,WANG Bo,GUO Xuan.Relation of Toll-like Receptor 4 and Monocyte Chemoattractant Protein-1 with Acute Coronary Syndrome[J].Journal of Modern Laboratory Medicine,2016,31(05):84-87.[doi:10.3969/j.issn.1671-7414.2016.05.022]
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Toll样受体4和单核细胞趋化蛋白1与急性冠脉综合征的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
84-87
栏目:
论著
出版日期:
2016-10-21

文章信息/Info

Title:
Relation of Toll-like Receptor 4 and Monocyte Chemoattractant Protein-1 with Acute Coronary Syndrome
文章编号:
1671-7414(2016)05-084-04
作者:
王 慧; 王 博; 郭 瑄
西安市第一医院,西安 710002
Author(s):
WANG Hui; WANG Bo; GUO Xuan
the First Hospitalof Xi'an,Xi'an 710002,China
关键词:
Toll样受体4(TLR4);  单核细胞趋化蛋白1(MCP-1);  急性冠脉综合征;  稳定型心绞痛;  不稳定型心绞痛;  急性心肌梗死
分类号:
R541; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.05.022
文献标志码:
A
摘要:
目的 探讨Toll样受体4(TLR4)和单核细胞趋化蛋白1(MCP-1)与急性冠脉综合征的关系。方法 选择2015年1月～2016年3月西安市第一医院行冠状动脉造影确诊为冠心病患者60例,其中急性冠脉综合征(ACS)组39例,稳定性心绞痛(SA)组21例,ACS组又分为急性心肌梗死(AMI)组21例和不稳定性心绞痛(UAP)组18例。另选取30例造影正常者为对照组。采用酶联免疫吸附试验(ELISA)检测血清MCP-1含量,用流式细胞仪检测TLR4的表达。采用全自动生化分析仪检测各组患者空腹血糖、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)水平。结果 ACS组及SA组TLR4水平明显高于对照组(t=4.455,P=0.021)。ACS组患者血清MCP-1水平明显高于SA组(t=3.220,P=0.002)和对照组(t=6.197,P=0.000)。SA组MCP-1水平高于对照组(t=2.306,P=0.025)。经Spearman相关性检验,ACS组外周血单核细胞中TLR4水平与血清MCP-1水平呈正相关(r=2.389,P=0.025)。结论 MCP-1和TLR4可判定冠心病的病变程度,MCP-1与TRL4的联合检测对ACS的早期诊断、治疗有一定的临床价值。
Abstract:
Objective To investigate the relation of Toll-like receptor 4(TLR4)and monocyte chemoattractant protein-1(MCP-1)with acutecoronary syndrome.Methods 60 patients with coronary heart disease patients including 39 cases of acute coronary syndrome(ACS group),21 cases of stable angina(SA group)from January 2015-March 2016 in Xi'an First Hospital were in this observation.ACS group was divided into acute myocardialinfarction(AMI,n=21)and unstable angina pectoris(UAP,n=18).Another 30 cases with angiographically normal was included in control group.Enzyme-linked immunosorbent assay(ELISA)detection was used to detect the serum content of MCP-1,TLR4 expression was tested by flow cytometry.Triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were detected.Results TLR4 levels of ACS group was significantly higher than SA group(t=4.455,P=0.021).Serum MCP-1 levels of ACS group were significantly higher thanSA group(t=3.220,P=0.002)and control group(t=6.197,P=0.000).MCP-1 levels of ACS group were higher than control group(t=2.306,P=0.025).The Spearman correlation test TLR4 was positively with MCP-1(r=2.389,P=0.025).Conclusion MCP-1 and TLR4 may determine the severity of coronary heart disease,combined detection of MCP-1 and TRL4 can provide the clinical value for early diagnosis and treatment of ACS.

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展科技攻关项目(2016SF339)。
作者简介:王 慧(1980-),女,硕士,主治医师,研究方向:心血管疾病的临床研究。
通讯作者:郭 瑄(1971-),女,博士(在读),主任医师,研究方向:心血管疾病的临床研究。
更新日期/Last Update: 2016-10-30