[1]郭进京.孕中期母血PAPPA与PIGF在预测子痫前期发生的作用[J].现代检验医学杂志,2016,31(05):115-117.[doi:10.3969/j.issn.1671-7414.2016.05.032]
　GUO Jin-jing.Role of Maternal PAPPA and PIGF Levels at Second Trimester in the Prediction of Preeclampsia[J].Journal of Modern Laboratory Medicine,2016,31(05):115-117.[doi:10.3969/j.issn.1671-7414.2016.05.032]
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孕中期母血PAPPA与PIGF在预测子痫前期发生的作用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
115-117
栏目:
论著
出版日期:
2016-10-21

文章信息/Info

Title:
Role of Maternal PAPPA and PIGF Levels at Second Trimester in the Prediction of Preeclampsia
文章编号:
1671-7414(2016)05-115-03
作者:
郭进京
渭南市妇幼保健院检验科,陕西渭南 714000
Author(s):
GUO Jin-jing
Department of Laboratory Medicine,Weinan Municipal Maternal and Child Health Hospital,Shaanxi Weinan 714000,China
关键词:
子痫前期;  妊娠相关血浆蛋白A;  胎盘生长因子
分类号:
R714.245; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.05.032
文献标志码:
A
摘要:
目的 通过检测孕中期(15～19周)孕妇血清(妊娠相关血浆蛋白APAPPA)与(胎盘生长因子PIGF)的水平,评价该指标在预测孕末期子痫前期发生的作用。方法 采用前后测量的研究方法,选取2013年6月～2015年7月在渭南市妇幼保健院诊治的204例单胎孕妇,从孕中期一直观察至孕末期(36～40周)。其中孕末期89例诊断为子痫前期,115例为正常孕妇。分别检测其孕中期及孕末期PAPPA与PIGF水平等指标。结果 ①子痫前期患者,孕中期PAPPA与PIGF水平明显低于同期正常单胎孕妇(2.3 μg/ml vs 4.6 μg/ml,U=11.31,P=0.017; 78 pg/ml vs 160 pg/ml,U=8.26,P=0.003); ②子痫前期患者,孕末期PAPPA与PIGF明显低于其孕中期水平(1.6 μg/ml vs 2.3 μg/ml,U=9.41,P=0.011; 56 pg/ml vs 78 pg/ml,U=6.77,P=0.023); ③ROC曲线显示,孕中期PAPPA Cutoff值为2.2 μg/ml及PIGF Cutoff值为75 pg/ml时,子痫前期发生预测值特异度为61.7%,敏感度为87.8%,AUC为0.86(95%可信区间0.83～0.91)。结论 孕中期(15～19周)检测PAPPA与PIGF水平,可成为预测发生子痫前期的有用指标。
Abstract:
Objective To determine the PAPPA and PIGF levels in maternal serum at second trimester(15 to19 weeks)to evaluate the role of these in the prediction of preeclampsia at last trimester.Methods Using premeasure postmeasure design,identified 204 singleton pregnancies within 15 to 19 weeks of gestation that followed 89 who had developed preeclampsia during 36 and 40 weeks,gestation at Weinan Municipal Maternal and Child Health Hospital at June 2013 and July 2015,115 with normotensive pregnant.PAPPAand PIGF concentration were determined.Results ①PAPPAand PIGF levels were significantly reduced in the preeclampsia groups compared to the normotensive pregnant group at second trimester(2.3 μg/ml vs 4.6 μg/ml,U=11.31,P=0.017; 78 pg/ml vs 160 pg/ml,U=8.26,P=0.003).②PAPPA and PIGF levels were significantly reduced at last trimester compared to second trimester in the preeclampsia groups(1.6 μg/ml vs 2.3 μg/ml,U=9.41,P=0.011; 56 pg/ml vs 78 pg/ml,U=6.77,P=0.023).③Receiver operatingcharacteristic curve analysis showed that at second trimester(at 15 to 19 weeks)a cutoff value of 2.2 μg/ml for PAPPA and a cutoff value of 75pg/ml for PIGFwere able to predict preeclampsia with specificity,sensitivity and area underthe curve(AUC)61.7%,87.8%,AUC 0.86(95% CI,0.83～0.91)respectively.Conclusion Measuring PAPPA and PIGF in the second trimester(at 15 to 19 weeks)may be useful in the prediction of preeclampsia.

参考文献/References:

[1] Ozdamar O,Gun I,Keskin U,et al.The role of maternal serumbeta-HCG and PAPPA levels at gestational weeks 10 to 14 in the prediction of pre-eclampsia[J].Pak J Med Sci,2014,30(3):568-573.
[2] Yiniemi A,Makikallio K,Korpimaki T,et al.Combination of PAPPA,fhCGβ,AFP,PIGF,sTNFR1,and maternal characteristics in prediction of early-onsetpreeclampsia[J].Clinical Medicine Insights:Reproductive Health,2015,9(1):13-20.
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[4] Zadeh NM,Naghshvar F,Peyvandi S,et al.PP13 and PAPP-A in the first and second trimesters:predictive factors for preeclampsia?[J].ISRN Obstetricsand Gynecology,2012(2012):263871.
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备注/Memo

备注/Memo:

作者简介:郭进京(1971-),男,硕士研究生,副主任医师,研究方向:分子生物学,E-mail:guo20050627@126.com。
更新日期/Last Update: 2016-10-30