[1]李兵,傅尧,符义富,等.IL-17F在口腔鳞状细胞癌患者血清中的表达及意义[J].现代检验医学杂志,2016,31(06):77-78，81.[doi:10.3969/j.issn.1671-7414.2016.06.021]
　LI Bing,FU Yao,FU Yi-fu,et al.Expression of Interleukin 17F in Serum of Oral Squamous Cell Carcinoma Patients and Its Clinic Significance[J].Journal of Modern Laboratory Medicine,2016,31(06):77-78，81.[doi:10.3969/j.issn.1671-7414.2016.06.021]
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IL-17F在口腔鳞状细胞癌患者血清中的表达及意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
77-78，81
栏目:
论著
出版日期:
2016-12-20

文章信息/Info

Title:
Expression of Interleukin 17F in Serum of Oral Squamous Cell Carcinoma Patients and Its Clinic Significance
作者:
李兵; 傅尧; 符义富; 游丽萍; 刘畅
南京大学医学院附属口腔医院检验科,南京 210008
Author(s):
LI Bing; FU Yao; FU Yi-fu; YOU Li-ping; LIU Chang
Department of Clinical Laboratory,Affilioted Nanjing Stomatological Hospital,Nanjing University Medical School,Nanjing 210008,China
关键词:
IL-17F;  口腔鳞状细胞癌;  血清;  筛查指标
分类号:
R739.85; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.06.021
文献标志码:
A
摘要:
目的 探讨IL-17F(interleukin 17F)在口腔鳞状细胞癌(OSCC)患者血清中的表达及意义。方法 收集33例健康对照者、25例经病理证实为白斑的患者和80例OSCC患者的血清,用ELISA方法检测IL-17F的表达水平,分析其与临床病理参数的关系。结果 OSCC患者血清IL-17F水平为65.1±7.2 pg/ml,显著低于健康对照者(202.2±31.5 pg/ml)和白斑患者(168.2±17.4 pg/ml),差异均具有统计学意义(t=6.16,6.22,P<0.05),OSCC患者血清中IL-17F水平与TNM分期明显相关(P<0.05)。受试者工作特征曲线(ROC曲线)显示血清中IL-17F能够很好地区分健康人和OSCC患者(P<0.05),其最佳临界值为37.8 pg/ml。结论 OSCC患者血清中IL-17F的表达降低,提示其可能与肿瘤发生、发展相关。
Abstract:
Objective This study focus on the serum expression of IL-17F(interleukin 17F)and its' clinical diagnostic value for normal,leukoplakia patient and Oral Squamous Cell Carcinoma(OSCC)serum specimens.Methods The concentration of IL-17F in the serum was assessed by ELISA in healthy donors(n=33),leukoplakia patients(n=25)andOSCC patients(n=80).Results IL-17F concentrationwas lower in OSCC patients than in healthy donors and leukoplakia patients(65.1 pg/ml vs 202.2 pg/ml or 168.2 pg/ml,t=6.16,6.22,P<0.05).The expression of IL-17F was positively associated to TNM stage in OSCC(P<0.05).The receiver operating characteristic(ROC)curve suggests that IL-17F in serum was a good diagnostic marker to discriminate healthy people from leukoplakiapatients,the cutoff values was 37.8 pg/ml.Conclusion The expression of IL-17F in serum correlated to OSCC progression and could be a potential diagnostic biomarker for oral disease.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:江苏省临床医学科技专项(BL2013005),江苏省卫生厅课题项目(H201441)。 作者简介:李 兵(1986-),男,硕士,主管技师,主要从事临床免疫学检验,E-mail:bluk222@163.com。 通信作者:孙国文,男,副教授,Tel:025-83620330。
更新日期/Last Update: 2016-12-20