[1]郭飞波.CypA,BNP,ET-1浓度在老年慢性心衰患者中的表达及临床意义[J].现代检验医学杂志,2016,31(06):88-91.[doi:10.3969/j.issn.1671-7414.2016.06.025]
　GUO Fei-bo.Expression Characteristics and Clinical Significance of CypA,BNP and ET-1 in Elderly Patients with Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2016,31(06):88-91.[doi:10.3969/j.issn.1671-7414.2016.06.025]
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CypA,BNP,ET-1浓度在老年慢性心衰患者中的表达及临床意义()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
88-91
栏目:
论著
出版日期:
2016-12-20

文章信息/Info

Title:
Expression Characteristics and Clinical Significance of CypA,BNP and ET-1 in Elderly Patients with Chronic Heart Failure
作者:
郭飞波
天门市第一人民医院检验科,湖北天门 431700
Author(s):
GUO Fei-bo
Department of Clinical Laboratory, the First People's Hospital of Tianmen,Hubei Tianmen 431700,China
关键词:
脑钠肽;  慢性心衰;  亲环素A;  内皮素-1
分类号:
R541.6; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.06.025
文献标志码:
A
摘要:
目的 探讨环亲素A(CypA)、脑钠肽(BNP)、内皮素-1(ET-1)在老年慢性心衰患者中的表达特征及临床意义。方法 选取湖北省天门市第一人民医院在2015年6月～2016年6月收治的56例老年慢性心衰患者作为研究组,另选取同期在该院进行健康体检的46例健康老年人作为对照组,研究对象均经心电图等相关检查确诊,并排除并发风湿免疫性疾病者、伴有先天性心脏病者、伴有血液疾病者、近期有感染病史者、凝血功能障碍者、并发恶性肿瘤者。运用ELISA法进行BNP,CypA和ET-1检测,运用乳胶免疫比浊法进行超敏C反应蛋白(hs-CRP)检测,采用t检验或F检验对比、分析检测结果。结果 研究组患者的BNP,CypA,hs-CRP和ET-1水平分别为368.42±67.05 ng/L,5.47±2.11 ng/L,18.32±2.33 mg/L和110.62±33.62 mg/L,对照组分别为159.40±57.42 ng/L,2.89±0.36 ng/L,8.40±1.16 mg/L和65.55±27.63 mg/L,研究组的BNP,CypA,hs-CRP,ET-1水平均显著高于对照组(t=16.700,8.189,26.306,7.290,P<0.05)。NYHA分级Ⅰ级患者的BNP,CypA,hs-CRP,ET-1水平分别为210.6±48.39 ng/L,68.66±12.87 ng/L,10.71±2.60 mg/L和87.21±12.41 mg/L; Ⅱ级患者分别为234.83±54.31 ng/L,73.13±16.48 ng/L,11.68±2.25 mg/L和92.32±13.32 mg/L; Ⅲ级患者分别为313.13±66.42 ng/L,96.82±18.47 ng/L,16.68±2.02 mg/L和113.54±21.85 mg/L; Ⅳ级患者分别为395.50±69.47 ng/L,111.13±19.43 ng/L,19.25±3.57 mg/L和127.36±18.73 mg/L。研究组不同NYHA心功能分级患者的BNP,CypA,hs-CRP,ET-1水平比较,差异均有统计学显著性意义(F=8.36,7.98,8.55,8.93,均P<0.05)。研究组血清BNP与CypA呈正相关关系(r=0.49),hs-CRP与CypA呈正相关关系(r=0.57),hs-CRP与BNP呈正相关关系(r=0.77),CypA与ET-1的表达呈正相关关系(r=0.53,P<0.05)。结论 老年慢性心衰患者的血清BNP,CypA,ET-1表达明显上调,检测BNP,CypA,ET-1可为临床评估病变程度提供可靠依据。
Abstract:
Objective To investigate the expression characteristics and clinical significance of CypA,BNP and ET-1(Endothelin-1)in elderly patients with chronic heart failure.Methods 56 cases of elderly patients with chronic heart failure in Hubei Tianmen First People's Hospital as study group,selected another 46 cases of healthy elderly peoplein the same period as control group.Research objects were diagnosed by the relevant electrocardiogram and exclude merger rheumatic autoimmune diseases,associated with congenital heart disease,blood diseases associated with the recent history of infection,coagulation disorders,combinedmalignancy.Used ELISA methodexamine BNP,CypA and ET-1,used latex turbidimetric immunoassay to examine hs-CRP(high-sensitivity C-reactive protein),and used t-test or F-test comparison analysed test results.Results The BNP,CypA,hs-CRP and ET-1 levels of study group were 368.42±67.05 ng/L,5.47±2.11 ng/L,18.32±2.33 mg/L and 110.62±33.62 mg/L.Control group were 159.40±57.42 ng/L,2.89±0.36 ng/L,8.40±1.16 mg/L and 65.55±27.63 mg/L.TheBNP,CypA,hs-CRP and ET-1 levels of study group were significantly higher than control group(t=16.700,8.189,26.306,7.290,P<0.05).The BNP,CypA,hs-CRP and ET-1 levels of NYHA classification grade Ⅰ patients were 210.6±48.39 ng/L,68.66±12.87 ng/L,10.71±2.60 mg/L and 87.21±12.41 mg/L.NYHA classification grade Ⅱ patients were 234.83±54.31 ng/L,73.13±16.48 ng/L,11.68±2.25 mg/L and 92.32±13.32 mg/L.NYHA classification grade Ⅲ patients were 313.13±66.42 ng/L,96.82±18.47 ng/L,16.68±2.02 mg/L and 113.54±21.85 mg/L,NYHA classification grade Ⅳ patients were 395.50±69.47 ng/L,111.13±19.43 ng/L,19.25±3.57 mg/L and 127.36±18.73 mg/L.The BNP,CypA,hs-CRP and ET-1 levels of different NYHA class patients compared,there were significant differences(F=8.36,7.98,8.55,8.93,all P<0.05).Serum BNP in study group with CypA showed a positively relationship(r=0.49),hs-CRP with CypA showed a positively relationship(r=0.57),hs-CRP with BNP showed a positively relationship(r=0.77),CypA withET-1 showed a positively relationship(r=0.53,P<0.05).Conclusion Serum BNP,CypA and ET-1 in elderly patients with chronic heart failure was significantly upregulated,and detecting BNP,CypA and ET-1 able to assess the clinical severity provide a reliable basis.

参考文献/References:

[1] 丛 欢,李 磊,聂 鑫.老年慢性心衰患者血清中细胞质亲环蛋白A、血清胱抑素C和基质金属蛋白酶-9的表达及意义[J].中国老年学杂志,2013,33(13):3172-3173. Cong H,Li L,Nie X.In patients with chronic heart failure in the elderly cytoplasmic protein cyclophilin A,Expression and significance of serum cystatin C and MMP-9[J].Chinese Journal of Gerontology,2013,33(13):3172-3173.
[2] 李德璇,王玉明,杨红玲,等.亲环素A与慢性心力衰竭相关性的研究[J].现代检验医学杂志,2015,30(1):31-33. Li DX,Wang YM,Yang HL,et al.Study on the relationship between cyclophilin A and chronic heart failure[J].Journal of Modern Laboratory Medicine,2015,(1):31-33.
[3] 杨红玲,肖本胜,何亚磊,等.慢性心力衰竭的临床指标学特点研究[J].中国实用医药,2013,8(18):22-23. Yang HL,Xiao BS,He YL,et al.Research on characteristics of clinical indicators in chronic cardiac failure[J].China Practical Medical,2013,8(18):22-23.
[4] 王茂林,唐 碧,吴士礼,等.血清亲环素A与慢性心力衰竭关系的研究[J].淮海医药,2015,33(2):111-112. Wang ML,Tang B,Wu SL,et al.Relation of cyclophilin A and chronic heart failure[J].J Huaihai Medicine,2015,33(2):111-112.
[5] 肖本胜,郭 涛.心力衰竭严重程度与生化指标的关系[J].慢性病学杂志,2013,14(11):837-840. Xiao BS,Guo T.Relationship between the severity of heart failure and biochemical traits[J].Chronic Pathematology Journal,2013,14(11):837-840.
[6] 张之栩,魏 群.血清BNP水平与心衰程度相关性的临床研究[J].中国实验诊断学,2010,14(8):1216-1217. Zhang ZX,Wei Q.The correlation between the serum BNP levels and the degree of heart failure with heart failure[J].Chinese Journal of LaboratoryDiagnosis,2010,14(8):1216-1217.
[7] 王智明.急性失代偿性心衰患者NTpro-BNP/BNP与NTpro-BNP,BNP对患者预后的预测价值比较[J].中国医药导报,2016,13(2):16-19. Wang ZM.Comparison of predicting value of NTpro-BNP/BNP,NTpro-BNP and BNP of patients with acute decompensated heart failure prognosis[J].China Medical Herald,2016,13(2):16-19.
[8] Zhang XM,Wang WJ,Yu YL,et al.BNP and NT-proBNP assays for heart-failure diagnosis in patients with cerebral infarction[J].Laboratory Medicine,2013,44(1):46-50.
[9] Satoh K.Cyclophilin a in cardiovascular homeostasis and diseases[J].The Tohoku Journal of Experimental Medicine,2015,235(1):1-15.
[10] 李永贵,谭华清,杨志远.nt-bnp在心衰合并慢性肾功能不全患者中的临床意义[J].河北医学,2013,19(6):893-895. Li YG,Tan HQ,Yang ZY.Nt-bnp heart failure in patients with chronic renal insufficiency The clinical significance of the merger[J].Hebei Medical,2013,19(6):893-895.

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备注/Memo

备注/Memo:
作者简介:郭飞波(1980-),硕士,主管技师,研究方向:病毒免疫与分子病毒学,E-mail:51325119@qq.com。
更新日期/Last Update: 2016-12-20