[1]李迪,李艳,彭锐.EB病毒DNA载量与儿童肝肾损害的研究[J].现代检验医学杂志,2016,31(06):127-129.[doi:10.3969/j.issn.1671-7414.2016.06.037]
　LI Di,LI Yan,PENG Rui.Correlation Study between Children Hepatorenal Damage and EBV-DNA Load[J].Journal of Modern Laboratory Medicine,2016,31(06):127-129.[doi:10.3969/j.issn.1671-7414.2016.06.037]
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EB病毒DNA载量与儿童肝肾损害的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
127-129
栏目:
检验与临床
出版日期:
2016-12-20

文章信息/Info

Title:
Correlation Study between Children Hepatorenal Damage and EBV-DNA Load
作者:
李迪; 李艳; 彭锐
武汉大学人民医院检验医学中心,武汉 430060
Author(s):
LI Di; LI Yan; PENG Rui
Department of Clinical Laboratory, Renmin Hospital of Wuhan University,Wuhan 430060,China
关键词:
EB病毒;  DNA载量;  肝损害;  肾损害;  儿童
分类号:
R373.11; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.06.037
文献标志码:
A
摘要:
目的 探讨EB病毒DNA载量与肝、肾功能的关系。方法 收集2016年4月～7月入院147例EB病毒DNA阳性患儿,检测其EB病毒DNA载量和生化指标; 收集健康对照组80例。按照DNA载量的高低,分为低载量组80例,中载量组41例,高载量组26例,分析比较不同DNA载量与肝功能、年龄、性别的关系。结果 EB病毒DNA低载量组、中载量组、高载量组肝损害率分别为17.50%,43.90%和61.54%; 肾损害率分别为3.75%,12.2%和37.5%。DNA载量越高,发生肝、肾损害的概率越大,差异具有统计学意义(χ2=20.58,8.38; P值均<0.05); 低年龄组DNA载量(4.93±0.75)高于中年龄组(4.60±0.83)与大年龄组(4.63±0.84),差异具有统计学意义(Z=-2.73,P=0.006),中年龄组DNA载量对数与高年龄组DNA载量对数间差异无统计学意义(Z=-0.27,P=0.788)。女患儿组DNA载量对数(4.55±0.62)低于男患儿组DNA载量对数(4.93±0.86),差异具有统计学意义(Z=-2.42,P=0.015)。患儿组清蛋白低于对照组,差异具有统计学意义(Z=-3.31,P<0.005)。结论 小儿感染EB病毒,EB病毒DNA载量越高,发生肝肾损害的可能性越大。
Abstract:
Objective To study the relationship between function of hepatorenal and DNA load of EBV.Methods 147 children whose EBV-DNA were positive were collected from April 2016 to July 2016,and their EBV-DNA load were tested.80 cases of normal children were collected as control group.ALL of them were divided into low load group(n=80),middle load group(n=41),high load group(n=26)by DNA load.Sex,age andcondition of hepatorenal in each group was compared.Results Liver damage rate in low load group,middle load group and high load group was 17.50%,43.90% and 61.54% respectively.Renal damage rate in low loadgroup, middle load group and high load group was 3.75%,12.2% and 37.5% respectively.The higher DNA load was,the worse condition of hepatorenal got.The difference was statistically significant(P<0.05).The logarithm of DNA loadin low age group(4.93±0.75)were significantly higher(Z=-2.73,P=0.006)than that in middle age group(4.60±0.83)as well as in high age group(4.63±0.84).There was no significant difference between the the logarithm of DNA load in middle age group and that in high age group(Z=-0.27,P=0.788).The logarithm of DNA load in girl group(4.55±0.62)was significant lower(Z=-2.42,P=0.015)than boy group(4.93±0.86).The levels of ALB in patient group were significant lower than control group(Z=-3.31,P<0.005).Conclusion With the levels of DNA load ascending, the possibility of occurrence live damage as well as renal damage get higher.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:李迪(1993-),男在读硕士,E-mail:344561021@qq.com。 通讯作者:李 艳,E-mail: yanlitf1120@163.com。
更新日期/Last Update: 2016-12-20