[1]卜晓敏,宋佳希,樊春荔,等.颅脑损伤患者血清αⅡ血影蛋白裂解产物(SBDPs)水平检测的临床意义[J].现代检验医学杂志,2017,32(01):9-11,15.[doi:10.3969/j.issn.1671-7414.2017.01.003]
　BU Xiao-min,SONG Jia-xi,FAN Chun-li,et al.Study on Serum Levels of SBDPs and Their Clinical Significance in Patients with Traumatic Brain Injury[J].Journal of Modern Laboratory Medicine,2017,32(01):9-11,15.[doi:10.3969/j.issn.1671-7414.2017.01.003]
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颅脑损伤患者血清αⅡ血影蛋白裂解产物(SBDPs)水平检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
9-11,15
栏目:
论著
出版日期:
2017-01-25

文章信息/Info

Title:
Study on Serum Levels of SBDPs and Their Clinical Significance in Patients with Traumatic Brain Injury
文章编号:
1671-7414(2017)01-009-04
作者:
卜晓敏1; 宋佳希1; 樊春荔1; 万淑君1; 郭鹏涛2; 马艳娟2; 汪俊军1
1.南京大学医学院附属金陵医院 临床检验科,南京 210002;
2.解放军第四十一医院,西藏山南 856000
Author(s):
BU Xiao-min1; SONG Jia-xi1; FAN Chun-li1; WANShu-jun1; GUO Peng-tao2; MA Yan-juan2;  WANG Jun-jun1
1.Department of Clinical Laboratory Medicine, Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China;
2.Department of Pathology,No.41 Hospital of PLA,Xizhang Shannan 856000,China
关键词:
颅脑损伤;  血清;  αⅡ血影蛋白裂解产物;  生物标志物
分类号:
R651.15; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.01.003
文献标志码:
A
摘要:
目的 分析脑外伤患者血清中αⅡ血影蛋白裂解产物(SBDPs,包括SBDP120和SBDP145)水平,探讨其对该病尤其是轻型脑外伤患者的临床价值。方法 采用酶联免疫吸附法检测43例重型脑外伤(sTBI)患者、43例轻型脑外伤(mTBI)患者和43例常规体检正常者(对照组)血清SBDP145和SBDP120水平,受试者工作特征曲线(ROC)评估SBDPs对sTBI,mTBI,判断头颅CT阴性和阳性患者的辅助诊断效能。结果 三组间血清SBDP145水平差异无统计学意义(F=1.340,P＞0.05)。对照组,mTBI及sTBI SBDP120含量分别为7.06±2.23,11.67±9.14和12.64±11.44ng/ml。与对照组相比,sTBI组(F=9.873,P=0.001)和mTBI组(F=9.873,P=0.008)血清SBDP120均显著升高,差异有统计学意义; 但sTBI组和mTBI组间SBDP120水平差异无统计学意义(F=9.873,P=0.515＞0.05)。SBDP120鉴别TBI和对照组的AUC为0.781(95% CI:0.690～0.872,P＜0.001); 鉴别mTBI和对照组的AUC为0.736(95% CI:0.624～0.848,P＜0.001); 鉴别头颅CT阴性和阳性患者的AUC为0.709(95% CI: 0.582～0.837,P=0.007＜0.01)。结论 轻型脑外伤患者血清SBDP120水平显著升高,是潜在的轻型脑外伤辅助诊断生物标志物。
Abstract:
Objective To analyze the changes of serum levels of αII-spectrin breakdown products(SBDPs)in traumatic brain injury(TBI)patients,and further to investigate the clinical diagnosis value of SBDPs for patients with TBI,especially with mTBI.Methods The serumlevels of SBDPs were examined in 43 severe TBI(sTBI)patients,43 mild TBI(mTBI)patients and 43 healthy controls using enzyme linked immunosorbent assay(ELISA).The diagnostic usefulness of SBDPs for TBI patients were assessed by Receiver Operating Characteristic(ROC)curves analysis.Results There was no significant difference of SBDP145 among the three groups(F=1.340,P＞0.05).Serum levels of SBDP120 in controls,mTBI and controls were7.06±2.23,11.67±9.14 and 12.64±11.44 ng/ml,respectively.Compared with controls,serum levels of SBDP120 were significantly higher in patients withsTBI(F=9.873,P=0.001)and mTBI(F=9.873,P=0.008),while there was no significant difference of SBDP120 between sTBI patients and mTBI patients(F=9.873,P=0.515＞0.05).The area under ROC curve(AUC)of SBDP120 for TBI patients was 0.781(95% CI:0.690～0.872,P＜0.001).For mTBI patients,the area under ROC curve was 0.736(95% CI:0.624～0.848,P＜0.001).And for discriminating TBI patients with CT negative or positive,the area under ROCcurve was 0.709(95% CI:0.582～0.837,P=0.007＜0.01).Conclusion The serum levels of SBDP120 were significantly increased in TBIpatients,especially mTBI patients.And the serum levels of SBDP120 can be usedas potential non-invasive biomarker for mTBI patients.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81271904,81401742,81572073和81572074); 国家重大科学仪器设备开发专项(2012YQ03026109); 成都军区课题(C41007)。
作者简介:卜晓敏(1989-),女,医学硕士研究生,主要研究方向:创伤性颅脑损伤生物标志物,E-mail:xiaominbubu@163.com。
通讯作者:汪俊军(1966-),男,博士,主任技师,教授,E-mail:wangjj9202@163.com。
更新日期/Last Update: 2017-01-20