[1]周 琰,吴文浩,吴 炯,等.HCV RNA载量、FIB-4指数和25羟维生素D水平在丙型肝炎临床应用中的价值[J].现代检验医学杂志,2017,32(01):30-33,37.[doi:10.3969/j.issn.1671-7414.2017.01.009]
　ZHOU Yan,WU Wen-hao,WU Jiong,et al.Clinical Application Value of the Result of the HCV RNA,FIB-4 and Levels of 25-Hydroxy Vitamin D for Patients with Hepatitis C[J].Journal of Modern Laboratory Medicine,2017,32(01):30-33,37.[doi:10.3969/j.issn.1671-7414.2017.01.009]
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HCV RNA载量、FIB-4指数和25羟维生素D水平在丙型肝炎临床应用中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
30-33,37
栏目:
论著
出版日期:
2017-01-25

文章信息/Info

Title:
Clinical Application Value of the Result of the HCV RNA,FIB-4 and Levels of 25-Hydroxy Vitamin D for Patients with Hepatitis C
文章编号:
1671-7414(2017)01-030-05
作者:
周 琰; 吴文浩; 吴 炯; 张春燕; 王蓓丽; 郭 玮; 潘柏申
复旦大学附属中山医院检验科,上海 200032
Author(s):
ZHOU Yan; WU Wen-hao; WU Jiong; ZHANG Chun-yan; WANGBei-li; GUO Wei; PAN Bai-shen
Department of Clinical Laboratory Medicine, Zhongshan Hospital of Fudan University,Shanghai 200032,China
关键词:
25羟维生素D;  丙型肝炎;  HCV RNA;  FIB-4评分
分类号:
R512.63; R392.11
DOI:
10.3969/j.issn.1671-7414.2017.01.009
文献标志码:
A
摘要:
目的 分析丙型肝炎患者肝纤维化指数(FIB-4评分)、HCVRNA载量和血清25羟维生素D(25OH-D)水平之间的关系。方法 收集255例丙型肝炎患者和218例表面健康人群的血清标本,检测血清25OH-D水平、HCV RNA载量以及FIB-4指数评分标准中的3项指标[包括丙氨酸氨基转移酶(ALT)、谷氨酸氨基转移酶(AST)和血小板(PLT)]。比较丙型肝炎组与健康对照组之间25OH-D浓度的差异; 根据FIB-4评分标准分组,统计HCV RNA载量、25OH-D浓度和FIB-4指数之间的关系。结果丙型肝炎组25OH-D浓度为48.16±1.41 nmol/L,明显低于对照组(60.42±1.34 nmol/L; t=4.682,P＜0.01)。丙型肝炎组中25OH-D缺乏(＜50 nmol/L)和严重缺乏(＜ 25 nmol/L)的比例为42.35%(108/255)和14.90%(38/255),明显高于对照组[27.98%(91/218)和3.67%(8/218); t=5.216,P＜0.01)]。相关性分析表明HCV RNA阳性组病毒载量对数值与相应的25OH-D水平无相关性(r2=0.018 8,P=0.412)。根据25OH-D水平四分位分组,25OH-D水平浓度随FIB-4指数增加而减低,各组中不同纤维化程度的丙型肝炎患者比例差异有统计学意义(χ2=8.190,P=0.042); 根据HCV RNA载量四分位分组,FIB-4指数分级各组间患者例数分布差异无统计学意义(χ2=1.874,P＞0.05)。结论 丙型肝炎患者25OH-D水平显著低于健康对照组,对此类人群应适当补充维生素D。丙型肝炎患者FIB-4指数和25OH-D浓度显著相关,和HCVRNA病毒载量不相关。
Abstract:
Objective To analyze the effects of 25-hydroxyvitamin D[25(OH)D] on the result of the HCV RNA and the FIB-4 in the patientswith hepatitis C.Methods 255 serum samples were random collected from the patients with hepatitis C and 218 serum samples were random collected from the healthy people.The 25(OH)D,HCV RNA,aspartate aminotransferase(AST),alanine aminotransferase(ALT)and blood platelet(PLT)were detected.Then,compared the results of the 25(OH)D in the patients with hepatitis C and the healthy group.Analyzed the relevance between the concentration of 25(OH)D and HCV RNA.According to the quartile concentration of the 25(OH)D,the patients with hepatitis C were categorized to four groups.The relationship of FIB-4 between HCVRNAand 25(OH)D was analyzed.Results The average concentration of the 25(OH)D in the patients with hepatitis C and healthy people were 48.16±1.41 nmol/L vs 60.42±1.34 nmol/L,with a significant difference(t=4.682,P＜0.01).There were 38 patients(14.90%)had severe deficiency of 25(OH)D(＜25 nmol/L)in 255 patients with hepatitis C.And there were 8 patients(3.67%)had severe deficiency of 25(OH)D(＜25 nmol/L)in 218 healthy people,with a significant difference(t=5.216,P＜0.01).Then found no relevance between thelogarithmic of the HCV RNA and the concentration of the 25(OH)D(r2=0.018 8,P=0.412)and there was significant difference between the proportion ofFIB-4 in the highest quartile concentration of the 25(OH)D and the lowest quartile concentration of the 25(OH)D(χ2=8.190,P=0.042).Conclusion The patients with hepatitis C were easier to have a severe deficiency of 25(OH)D than the healthy people.The hepatitis C patients should beensuggested to supply the vitamin D.FIB-4 has a significant difference with 25(OH)D and no great effects on the result of the HCV RNA.

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备注/Memo

备注/Memo:
基金项目:上海青年临床医技人才(临床检验专业)培养资助计划(沪医卫基[2016]04号; 复旦大学附属中山医院青年资金(2016ZSQN-34); 国家自然基金面上项目(81572064); 上海市卫生计生系统重要薄弱学科建设项目(2015ZB0201)。
作者简介:周 琰(1981-),女,学士,主管技师,研究方向:免疫和分子诊断,Tel:13817754311。
通讯作者:潘柏申,E-mail:pan.baishen@zs-hospital.sh.cn。
更新日期/Last Update: 2017-01-20